Q8CCN5
PR
Gene name |
Bcas3 |
Protein name |
BCAS3 microtubule associated cell migration factor |
Names |
Breast carcinoma-amplified sequence 3 homolog, K20D4, Protein rudhira |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:192197 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CCN5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CCN5-F1 | Predicted | AlphaFoldDB |
42 variants for Q8CCN5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389190366 | 2 | N>K | No | EVA | |
| rs3412944330 | 63 | V>F | No | EVA | |
| rs3389196526 | 76 | N>I | No | EVA | |
| rs3389185135 | 88 | E>V | No | EVA | |
| rs3389203368 | 101 | M>K | No | EVA | |
| rs3389153666 | 102 | Q>L | No | EVA | |
| rs3389196500 | 110 | G>E | No | EVA | |
| rs3389158942 | 126 | A>V | No | EVA | |
| rs211795834 | 131 | A>T | No | EVA | |
| rs3389196508 | 138 | K>R | No | EVA | |
| rs234588159 | 193 | N>K | No | EVA | |
| rs3389126273 | 195 | R>W | No | EVA | |
| rs3402650622 | 234 | A>V | No | EVA | |
| rs3389153677 | 250 | C>* | No | EVA | |
| rs3389164160 | 426 | R>L | No | EVA | |
| rs3389192375 | 469 | Q>* | No | EVA | |
| rs3389176593 | 471 | L>M | No | EVA | |
| rs3389190350 | 492 | S>F | No | EVA | |
| rs3389192397 | 513 | G>A | No | EVA | |
| rs3389158959 | 514 | N>T | No | EVA | |
| rs3389196460 | 515 | P>S | No | EVA | |
| rs3389191267 | 520 | L>P | No | EVA | |
| rs3389199314 | 523 | L>S | No | EVA | |
| rs3389189991 | 537 | T>I | No | EVA | |
| rs3389126253 | 545 | T>A | No | EVA | |
| rs3389126222 | 619 | Y>C | No | EVA | |
| rs259522096 | 630 | R>W | No | EVA | |
| rs3389191270 | 650 | P>T | No | EVA | |
| rs3389126282 | 706 | S>T | No | EVA | |
| rs3389191210 | 718 | E>D | No | EVA | |
| rs3389191276 | 719 | D>Y | No | EVA | |
| rs3389126261 | 727 | E>G | No | EVA | |
| rs3389182877 | 737 | R>L | No | EVA | |
| rs3389176537 | 752 | S>T | No | EVA | |
| rs3389182899 | 753 | G>R | No | EVA | |
| rs3389191221 | 753 | G>V | No | EVA | |
| rs3389176606 | 754 | Q>H | No | EVA | |
| rs3389189976 | 787 | L>P | No | EVA | |
| rs3413118930 | 811 | D>N | No | EVA | |
| rs3402655328 | 883 | R>G | No | EVA | |
| rs3402707946 | 886 | S>G | No | EVA | |
| rs3389126289 | 918 | Q>L | No | EVA |
No associated diseases with Q8CCN5
1 regional properties for Q8CCN5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | BCAS3 domain | 572 - 792 | IPR022175 |
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell leading edge | The area of a motile cell closest to the direction of movement. |
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic microtubule | Any microtubule in the cytoplasm of a cell. |
| euchromatin | A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. |
| intermediate filament cytoskeleton | Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| phagophore assembly site | Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| acetyltransferase activator activity | Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule. |
| beta-tubulin binding | Binding to the microtubule constituent protein beta-tubulin. |
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| histone acetyltransferase binding | Binding to an histone acetyltransferase. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| nuclear receptor binding | Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. |
| phosphatidylinositol binding | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
19 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| autophagy | The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. |
| cellular response to estrogen stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. |
| Golgi organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. |
| microtubule organizing center organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow. |
| negative regulation of focal adhesion assembly | Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. |
| negative regulation of GTPase activity | Any process that stops or reduces the rate of GTP hydrolysis by a GTPase. |
| positive regulation of actin cytoskeleton reorganization | Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization. |
| positive regulation of catalytic activity | Any process that activates or increases the activity of an enzyme. |
| positive regulation of endothelial cell migration | Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. |
| positive regulation of filopodium assembly | Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| positive regulation of intracellular protein transport | Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of establishment of cell polarity | Any process that modulates the frequency, rate or extent of establishment of cell polarity. |
| response to estrogen | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. |
| response to starvation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. |
| tube formation | Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNETMATDSP | RRPSRCTGGV | VVRPQAVTEQ | SYMESVVTFL | QDVVPQAYSG | SPLTEEKEKI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VWVRFENADL | NDTSRNLEFH | ELHSTGNEPP | LLVMIGYSDG | MQVWGIPISG | EAQELFSVRH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GPVRAARILP | APQLGAQKCD | NFAEKRPLLG | VCKSIGSSGT | TPPYCCVDLY | SLRTGEMVKS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IQFKTPIYDL | HCNKRILVVV | LQEKIAAFDS | CTFTKKFFVT | SCYPCPGPNM | NPIALGSRWL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AYAENKLIRC | HQSRGGACGD | NIQSYTATVL | SAAKTLKSGL | TMVGKVVTQL | TGTLPSGVTE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DDVALHCNSR | RSPLVPGIIT | VIDTETVGEG | QVLVSEDSDS | DGIVAHFPAH | EKPVCCMAFN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TSGMLLVTTD | TLGHDFHVFQ | ILTHPWSSSQ | CAVHHLYTLH | RGETEAKVQD | ICFSHDCRWV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VVSTLRGTSH | VFPINPYGGQ | PCVRTHMSPR | VVNRMSRFQK | SAGLEEIEQE | LTSKQGGRCS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PVPGLSSSPS | GSPLHGKLTS | QDSYNNFTNN | NPGNPRLSPL | PSLMVVTPLA | QIKQPMTLGT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ITKRTGPYLF | GAGCFSIKAP | CKVKSPPQIS | PSKSMGGEFC | VAAVFGTSRS | WFANNAGLKR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EKDQSKQVVV | ESLYIISCYG | TLVEHMIEPR | PISTAPKISD | DTPLEIMTSP | RASWTLVRTP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QWNELQPPFN | ANHPLLLAAE | AVQYYQLLLA | GSLPPGSPGP | ITRHGSYDSL | ASDHSGQEDE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EWLSQVEIVT | HTGPHRRLWM | GPQFHFKTIQ | TSGQTTVIST | SSSVLQSHGP | SDTPQPLLDF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DTDDLDLNSL | RIQPVRSDPV | SMPGSSRAVS | DRRGVSTVTD | AASGTFDRSV | TLLEVCGSWP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EGFGLRHMSS | MEHSEEGLRE | RLADAMAESP | SRDVVGSGTE | LQREGSIETL | SNSSGSTSGS |
| 910 | 920 | ||||
| IPRNFDGYRS | PLPTNESQPL | SLFPTGFP |