Q8CCK0
Gene name |
Macroh2a2 |
Protein name |
Core histone macro-H2A.2 |
Names |
Histone macroH2A2, mH2A2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:404634 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CCK0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CCK0-F1 | Predicted | AlphaFoldDB |
22 variants for Q8CCK0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389101514 | 15 | R>Q | No | EVA | |
| rs3389109040 | 21 | V>L | No | EVA | |
| rs3389102804 | 22 | I>T | No | EVA | |
| rs3389069933 | 35 | G>A | No | EVA | |
| rs3389110750 | 38 | K>* | No | EVA | |
| rs3389076070 | 95 | L>M | No | EVA | |
| rs3400087552 | 99 | T>S | No | EVA | |
| rs3389046433 | 111 | P>R | No | EVA | |
| rs3389101486 | 132 | P>VSDG* | No | EVA | |
| rs3389105744 | 133 | E>V | No | EVA | |
| rs3389109027 | 134 | K>SDG* | No | EVA | |
| rs3389046478 | 144 | K>R | No | EVA | |
| rs3400988892 | 184 | T>K | No | EVA | |
| rs3389098852 | 212 | V>M | No | EVA | |
| rs3389105791 | 235 | K>M | No | EVA | |
| rs3389112633 | 247 | E>D | No | EVA | |
| rs3389098816 | 294 | I>F | No | EVA | |
| rs3389080359 | 301 | A>T | No | EVA | |
| rs3389098786 | 319 | N>H | No | EVA | |
| rs3389095805 | 342 | S>C | No | EVA | |
| rs3389089210 | 363 | V>M | No | EVA | |
| rs1132840544 | 372 | K>R | No | EVA |
No associated diseases with Q8CCK0
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| Barr body | A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. |
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleosome | A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin DNA binding | Binding to DNA that is assembled into chromatin. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| RNA polymerase II transcription regulatory region sequence-specific DNA binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
| structural constituent of chromatin | The action of a molecule that contributes to the structural integrity of chromatin. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| dosage compensation | Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes. |
| establishment of protein localization to chromatin | The directed movement of a protein to a part of a chromosome that is organized into chromatin. |
| negative regulation of gene expression, epigenetic | An epigenetic process that silences gene expression at specific genomic regions through chromatin remodelling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the DNA. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| negative regulation of transcription of nucleolar large rRNA by RNA polymerase I | Any process that stops, prevents or reduces the frequency, rate or extent of transcription of nuclear large rRNA transcript mediated by RNA polymerase I. |
| nucleosome assembly | The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
| positive regulation of keratinocyte differentiation | Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGRSGKKKM | SKLSRSARAG | VIFPVGRLMR | YLKKGTFKYR | ISVGAPVYMA | AVIEYLAAEI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LELAGNAARD | NKKARIAPRH | ILLAVANDEE | LNQLLKGVTI | ASGGVLPRIH | PELLAKKRGT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KGKSETILSP | PPEKRGRKAA | SGKKGGKKSK | ATKPRTSKKS | KAKDSDKEGT | SNSTSEDGPG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DGFTILSSKS | LVLGQKLSLT | QSDISHIGSM | RVEGIVHPTT | AEIDLKEEIG | KALEKAGGKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FLETVKELRK | SQGPLEVAEA | AVSQSSGLAA | KFVIHCHIPQ | WGSDKCEEQL | EETIKNCLSA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AEDKKLKSVA | FPPFPSGRNC | FPKQTAAQVT | LKAISAHFDD | SSSSSLKNVY | FLLFDSESIG |
| 370 | |||||
| IYVQEMAKLD | TK |