Q8CCF0
PR
Gene name |
Prpf31 (Prp31) |
Protein name |
U4/U6 small nuclear ribonucleoprotein Prp31 |
Names |
Pre-mRNA-processing factor 31, U4/U6 snRNP 61 kDa protein, Protein 61K |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68988 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CCF0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CCF0-F1 | Predicted | AlphaFoldDB |
35 variants for Q8CCF0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388877979 | 14 | A>S | No | EVA | |
| rs3388869545 | 16 | E>D | No | EVA | |
| rs3388862146 | 18 | E>V | No | EVA | |
| rs261340072 | 26 | E>D | No | EVA | |
| rs3388846937 | 27 | E>G | No | EVA | |
| rs3388869606 | 38 | E>D | No | EVA | |
| rs3388875206 | 39 | T>I | No | EVA | |
| rs3388875197 | 61 | A>V | No | EVA | |
| rs3388875167 | 63 | I>N | No | EVA | |
| rs3388874858 | 70 | Y>* | No | EVA | |
| rs3388877967 | 75 | A>T | No | EVA | |
| rs233959333 | 76 | N>K | No | EVA | |
| rs13467200 | 77 | V>A | No | EVA | |
| rs3388873466 | 83 | P>S | No | EVA | |
| rs3388873986 | 89 | E>G | No | EVA | |
| rs3388865701 | 143 | G>D | No | EVA | |
| rs3388870755 | 156 | Q>H | No | EVA | |
| rs3388836173 | 162 | A>D | No | EVA | |
| rs3388836173 | 162 | A>V | No | EVA | |
| rs3388846993 | 173 | T>N | No | EVA | |
| rs3388870931 | 210 | S>F | No | EVA | |
| rs3388870952 | 214 | F>L | No | EVA | |
| rs3388870924 | 232 | M>V | No | EVA | |
| rs3388853577 | 238 | L>H | No | EVA | |
| rs3397187029 | 247 | C>S | No | EVA | |
| rs583900422 | 268 | L>F | No | EVA | |
| rs3388873417 | 290 | K>E | No | EVA | |
| rs3388875157 | 331 | W>* | No | EVA | |
| rs3388873923 | 359 | Y>* | No | EVA | |
| rs3388874814 | 361 | K>* | No | EVA | |
| rs3388870932 | 405 | G>R | No | EVA | |
| rs1134430071 | 473 | A>T | No | EVA | |
| rs3388862171 | 482 | S>N | No | EVA | |
| rs3388865307 | 483 | M>K | No | EVA | |
| rs3397545685 | 483 | M>L | No | EVA |
No associated diseases with Q8CCF0
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| Cajal body | A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. |
| MLL1 complex | A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| precatalytic spliceosome | A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. |
| spliceosomal tri-snRNP complex | A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP. |
| U2-type precatalytic spliceosome | A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs. |
| U4 snRNP | A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes. |
| U4/U6 x U5 tri-snRNP complex | A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs. |
| U4atac snRNP | A ribonucleoprotein complex that contains small nuclear RNA U4atac, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4atac snRNP, most of which remain associated with the U4atac snRNA both while the U4atac snRNP is free or assembled into the U4atac/U6atac complex or into a series of spliceosomal complexes. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| ribonucleoprotein complex binding | Binding to a complex of RNA and protein. |
| snRNP binding | Binding to a small nuclear ribonucleoprotein particle. |
| U4 snRNA binding | Binding to a U4 small nuclear RNA (U4 snRNA). |
| U4atac snRNA binding | Binding to a U4atac small nuclear RNA (U4atac snRNA). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| ribonucleoprotein complex localization | Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell. |
| spliceosomal tri-snRNP complex assembly | The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P49704 | PRP31 | Pre-mRNA-processing factor 31 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q8WWY3 | PRPF31 | U4/U6 small nuclear ribonucleoprotein Prp31 | Homo sapiens (Human) | PR |
| Q6NVP6 | prpf31 | U4/U6 small nuclear ribonucleoprotein Prp31 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLADELLAD | LEEAAEEEEG | GSYGEEEEEP | AIEDVQEETQ | LDLSGDSVKS | IAKLWDSKMF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AEIMMKIEEY | ISKQANVSEV | MGPVEAAPEY | RVIVDANNLT | VEIENELNII | HKFIRDKYSK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RFPELESLVP | NALDYIRTVK | ELGNSLDKCK | NNENLQQILT | NATIMVVSVT | ASTTQGQQLS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DEELERLEEA | CDMALELNAS | KHRIYEYVES | RMSFIAPNLS | IIIGASTAAK | IMGVAGGLTN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSKMPACNIM | LLGAQRKTLS | GFSSTSVLPH | TGYIYHSDIV | QSLPPDLRRK | AARLVAAKCT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LAARVDSFHE | STEGKVGYEL | KDEIERKFDK | WQEPPPVKQV | KPLPAPLDGQ | RKKRGGRRYR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KMKERLGLTE | IRKQANRMSF | GEIEEDAYQE | DLGFSLGHLG | KSGSGRVRQT | QVNEATKARI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SKTLQRTLQK | QSVVYGGKST | IRDRSSGTAS | SVAFTPLQGL | EIVNPQAAEK | KVAEANQKYF |
| 490 | |||||
| SSMAEFLKVK | GEKSGTMST |