P49704
PR
Gene name |
PRP31 (YGR091W) |
Protein name |
Pre-mRNA-processing factor 31 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGR091W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
7 variants for P49704
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-666540 | 66 | S>P | No | SGRP | |
| s07-666552 | 70 | T>A | No | SGRP | |
| s07-666819 | 159 | F>V | No | SGRP | |
| s07-666835 | 164 | K>R | No | SGRP | |
| s07-666888 | 182 | S>P | No | SGRP | |
| s07-667663 | 440 | V>A | No | SGRP | |
| s07-667824 | 494 | G>S | No | SGRP |
No associated diseases with P49704
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| precatalytic spliceosome | A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. |
| spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
| spliceosomal tri-snRNP complex | A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP. |
| U4 snRNP | A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes. |
| U4/U6 snRNP | A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4 and U6, a heptameric ring of Sm proteins associated with U4, the Lsm2-8 heptameric ring complex associated with U6, as well as several proteins that are unique to the U4 snRNP or U6 snRNPs, some of which remain associated with the U4/U6 snRNA both while the U4 snRNP is free or assembled into a series of spliceosomal complexes. |
| U4/U6 x U5 tri-snRNP complex | A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| spliceosomal snRNP assembly | The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. |
| spliceosomal tri-snRNP complex assembly | The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8WWY3 | PRPF31 | U4/U6 small nuclear ribonucleoprotein Prp31 | Homo sapiens (Human) | PR |
| Q8CCF0 | Prpf31 | U4/U6 small nuclear ribonucleoprotein Prp31 | Mus musculus (Mouse) | PR |
| Q6NVP6 | prpf31 | U4/U6 small nuclear ribonucleoprotein Prp31 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSEEDYFDE | LEYDLADEVN | EEKEDIQTKK | LTTVNCQTEK | FNPFEILPES | IELFRTLALI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SPDRLSLSET | AQILPKIVDL | KRILQQQEID | FIKLLPFFNE | IIPLIKSNIK | LMHNFLISLY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SRRFPELSSL | IPSPLQYSKV | ISILENENYS | KNESDELFFH | LENKAKLTRE | QILVLTMSMK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TSFKNKEPLD | IKTRTQILEA | NSILENLWKL | QEDIGQYIAS | KISIIAPNVC | FLVGPEIAAQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LIAHAGGVLE | FSRIPSCNIA | SIGKNKHLSH | ELHTLESGVR | QEGYLFASDM | IQKFPVSVHK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QMLRMLCAKV | SLAARVDAGQ | KNGDRNTVLA | HKWKAELSKK | ARKLSEAPSI | SETKALPIPE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DQPKKKRAGR | KFRKYKEKFR | LSHVRQLQNR | MEFGKQEQTV | LDSYGEEVGL | GMSNTSLQQA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VGATSGSRRS | AGNQAKLTKV | MKHRISEANQ | QADEFLISLG | HNTEQPNLSP | EMVQMHKKQH |
| 490 | |||||
| TNPEEETNWF | SGHG |