Q8CBG9

PR
Gene name
Rnf170
Protein name
E3 ubiquitin-protein ligase RNF170
Names
RING finger protein 170, RING-type E3 ubiquitin transferase RNF170
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:77733
EC number
2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

61-134 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8CBG9

Entry ID Method Resolution Chain Position Source
AF-Q8CBG9-F1 Predicted AlphaFoldDB

15 variants for Q8CBG9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs215483036 11 K>E No EVA
rs230642495 36 E>D No EVA
rs3388949498 46 F>C No EVA
rs244686958 52 D>N No EVA
rs3388932111 54 V>F No EVA
rs264668705 62 L>F No EVA
rs224479775 65 T>I No EVA
rs236714132 105 A>T No EVA
rs3388974542 109 F>L No EVA
rs3388977743 134 F>L No EVA
rs3388977515 142 Y>* No EVA
rs3388970969 146 G>W No EVA
rs3398767959 150 G>A No EVA
rs3388964994 151 A>V No EVA
rs3388970911 208 L>M No EVA

No associated diseases with Q8CBG9

4 regional properties for Q8CBG9

Type Name Position InterPro Accession
domain Zinc finger, RING-type 115 - 158 IPR001841
domain Domain of unknown function DUF1232 232 - 267 IPR010652
conserved_site Zinc finger, RING-type, conserved site 130 - 139 IPR017907
domain Zinc finger, C3HC4 RING-type 115 - 157 IPR018957

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
F1MK05 RNF170 E3 ubiquitin-protein ligase RNF170 Bos taurus (Bovine) PR
10 20 30 40 50 60
MQRYWRFQDN KIQDICFGVL GESWIQRPVM ARYYSEGQSL QQDDSFIEGV SDQVLVAVVV
70 80 90 100 110 120
SLALTATLLY ALLRNVQQNI HPENQELVRV LREQFQTEQD VPAPARQQFY TEMYCPICLH
130 140 150 160 170 180
QASFPVETNC GHLFCGSCII AYWRYGSWLG AISCPICRQT VTLLLTVFGE DDQSQDVIRL
190 200 210 220 230 240
RQDVNDYNRR FSGQPRSIME RIMDLPTLLR HAFREVFSVG GLFWMFRIRI MLCLMGAFFY
250 260 270 280
LISPLDFVPE ALFGILGFLD DFFVIFLLLI YISIMYREVI TQRLTR