F1MK05

PR
Gene name
RNF170
Protein name
E3 ubiquitin-protein ligase RNF170
Names
RING finger protein 170, RING-type E3 ubiquitin transferase RNF170
Species
Bos taurus (Bovine)
KEGG Pathway
EC number
2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

114-198 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F1MK05

Entry ID Method Resolution Chain Position Source
AF-F1MK05-F1 Predicted AlphaFoldDB

No variants for F1MK05

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for F1MK05

No associated diseases with F1MK05

No regional properties for F1MK05

Type Name Position InterPro Accession
No domain, repeats, and functional sites for F1MK05

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8CBG9 Rnf170 E3 ubiquitin-protein ligase RNF170 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAKYQGEVQS LKLDDDSVIE GVSDQVLVAV VVSLALIATL VYALFSRNAH QNIHPENQEL
70 80 90 100 110 120
VRVLREQLQT EQDAPAAARQ QFYTDMYCPI CLHQASLPVE TNCGHLFCGT CIVAYWRYGS
130 140 150 160 170 180
WLGAISCPIC RQTVTLLLPV FGENDQSQDV VSLHQDISDY NRRFSGQPRS IMERIMDLPT
190 200 210 220 230 240
LLRHAFREMF SVGGLFWMFR IRIILCLMGA FFYLISPLDF VPEALFGILG FLDDFFVIFL
250
LLIYISIMYR EVITQRLNR