Q8CBE3
Gene name |
Wdr37 (Kiaa0982) |
Protein name |
WD repeat-containing protein 37 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:207615 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CBE3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CBE3-F1 | Predicted | AlphaFoldDB |
12 variants for Q8CBE3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389284376 | 80 | R>C | No | EVA | |
| rs3403130208 | 129 | S>A | No | EVA | |
| rs3389267386 | 132 | K>R | No | EVA | |
| rs3389253386 | 220 | D>N | No | EVA | |
| rs3389199206 | 224 | H>R | No | EVA | |
| rs3389253399 | 273 | R>* | No | EVA | |
| rs3389260995 | 292 | L>M | No | EVA | |
| rs3389199215 | 308 | N>K | No | EVA | |
| rs3389269148 | 387 | S>R | No | EVA | |
| rs3389284385 | 408 | R>H | No | EVA | |
| rs3389268897 | 410 | D>Y | No | EVA | |
| rs3389284446 | 419 | C>Y | No | EVA |
No associated diseases with Q8CBE3
7 regional properties for Q8CBE3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 145 - 227 | IPR001680-1 |
| repeat | WD40 repeat | 272 - 405 | IPR001680-2 |
| repeat | WD40 repeat | 445 - 486 | IPR001680-3 |
| conserved_site | WD40 repeat, conserved site | 383 - 397 | IPR019775 |
| repeat | G-protein beta WD-40 repeat | 172 - 186 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 340 - 354 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 383 - 397 | IPR020472-3 |
Functions
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9FKH1 | SAP | Transcriptional regulator STERILE APETALA | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPTESGSCST | ARQAKQKRKS | HSLSIRRTNS | SEQERTGLPR | EMLEGQDSKL | PSSVRSTLLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LFGQIEREFE | NLYIENLELR | REIDTLNERL | AGEGQAIDGA | ELSKGQLKTK | ASHSTSQLSQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KLKTTYKAST | SKIVSSFKTT | TSRAICQLVK | EYIGHRDGIW | DVSVTRTQPI | VLGTASADHT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ALLWSIETGK | CLVKYAGHVG | SVNSIKFHPS | EQLALTASGD | QTAHIWRYVV | QLPTPQPVAD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TSQQISGEDE | IECSDKDEPD | IDGDVSSDCP | TVRVPLTSLK | SHQGVVIAAD | WLVGGKQVVT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ASWDRTANLY | DVETSELVHS | LTGHDQELTH | CCTHPTQRLV | VTSSRDTTFR | LWDFRDPSIH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SVNVFQGHTD | TVTSAVFTVG | DNVVSGSDDR | TVKVWDLKNM | RSPIATIRTD | SAINRINVCV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GQKIIALPHD | NRQVRLFDMS | GVRLARLPRS | SRQGHRRMVC | CSAWSEDHPI | CNLFTCGFDR |
| 490 | |||||
| QAIGWNINIP | ALLQEK |