AiPD: Autoinhibited Protein Database

Gene name	Eloa
Protein name	Elongin-A
Names	EloA, Elongin 110 kDa subunit, RNA polymerase II transcription factor SIII subunit A1, SIII p110, Transcription elongation factor B polypeptide 3
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:27224
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

45-551 (Predicted disordered autoinhibitory region) PR

45-551 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8CB77-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs27604649	35	I>V	No	EVA
rs3388718116	38	I>N	No	EVA
rs3388718131	49	G>E	No	EVA
rs3410608093	50	K>T	No	EVA
rs3388723044	89	F>Y	No	EVA
rs3388723059	113	Q>H	No	EVA
rs3388718061	122	R>L	No	EVA
rs3388698490	148	S>N	No	EVA
rs3388715769	176	H>L	No	EVA
rs3394823813	200	Q>L	No	EVA
rs256603483	206	H>Q	No	EVA
rs3388710174	245	K>E	No	EVA
rs3388727770	247	K>M	No	EVA
rs223679721	250	A>V	No	EVA
rs3394905822	261	V>E	No	EVA
rs3394823754	261	V>L	No	EVA
rs234866788	269	A>T	No	EVA
rs3388727750	272	K>R	No	EVA
rs3388727782	283	S>N	No	EVA
rs3388725482	299	R>I	No	EVA
rs3388725499	306	K>E	No	EVA
rs3388723084	338	Q>*	No	EVA
rs3388718049	370	K>I	No	EVA
rs3388720346	372	R>T	No	EVA
rs3412731930	374	N>D	No	EVA
rs3388722055	375	A>P	No	EVA
rs13468011	382	P>L	No	EVA
rs3388698478	384	H>R	No	EVA
rs3388722572	416	K>R	No	EVA
rs239507697	422	T>A	No	EVA
rs3388722864	424	S>N	No	EVA
rs3388710176	441	S>I	No	EVA
rs3388718042	449	K>I	No	EVA
rs3388717065	456	N>K	No	EVA
rs3388698565	485	I>T	No	EVA
rs3388718087	583	C>Y	No	EVA
rs3388722080	591	I>L	No	EVA
rs27619971	605	L>F	No	EVA
rs3388723079	641	R>H	No	EVA
rs3388722833	642	L>P	No	EVA
rs3394931193	712	S>T	No	EVA
rs3394923408	713	S>I	No	EVA
rs3394879073	713	S>R	No	EVA
rs3388722546	760	A>T	No	EVA

Type	Name	Position	InterPro Accession
domain	F-box domain	565 - 609	IPR001810
domain	Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type	7 - 78	IPR003617
domain	Transcription factor IIS, N-terminal	4 - 79	IPR017923

		Description
EC Number
Subcellular Localization	Nucleus	Localizes to sites of DNA damage
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
elongin complex	A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits.
site of DNA damage	A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
transcription elongation factor complex	Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.

Name	Definition
No GO annotations for molecular function

Name	Definition
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
transcription elongation by RNA polymerase II promoter	The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
transcription initiation at RNA polymerase II promoter	A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q14241	ELOA	Elongin-A	Homo sapiens (Human)	PR
Q8IYF1	ELOA2	Elongin-A2	Homo sapiens (Human)	PR