Q14241

PR
Gene name
ELOA
Protein name
Elongin-A
Names
EloA, Elongin 110 kDa subunit, RNA polymerase II transcription factor SIII subunit A1, SIII p110, Transcription elongation factor B polypeptide 3
Species
Homo sapiens (Human)
KEGG Pathway
hsa:6924
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

108-182 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for Q14241

Entry ID Method Resolution Chain Position Source
4HFX X-ray 254 A A/B/C/D 571-656 PDB
6ZUZ NMR - A 1-82 PDB
8OEV EM 286 A M 1-772 PDB
8OEW EM 280 A M 1-772 PDB
8OF0 EM 305 A M 1-772 PDB
AF-Q14241-F1 Predicted AlphaFoldDB

3 variants for Q14241

Variant ID(s) Position Change Description Diseaes Association Provenance
VAR_020104
CA684432
rs2235541
 145 T>M No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs520713
VAR_033850
CA19288745
 324 V>I No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
VAR_033851
CA684629
rs550252
 516 A>V No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD

No associated diseases with Q14241

3 regional properties for Q14241

Type Name Position InterPro Accession
domain F-box domain 592 - 636 IPR001810
domain Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type 33 - 104 IPR003617
domain Transcription factor IIS, N-terminal 30 - 105 IPR017923

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Localizes to sites of DNA damage
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
elongin complex A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
site of DNA damage A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
transcription initiation at RNA polymerase II promoter A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IYF1 ELOA2 Elongin-A2 Homo sapiens (Human) PR
Q8CB77 Eloa Elongin-A Mus musculus (Mouse) PR
10 20 30 40 50 60
MHGGRSCGPR TRREPSSGEE AAPVTAMAAE SALQVVEKLQ ARLAANPDPK KLLKYLKKLS
70 80 90 100 110 120
TLPITVDILA ETGVGKTVNS LRKHEHVGSF ARDLVAQWKK LVPVERNAEP DEQDFEKSNS
130 140 150 160 170 180
RKRPRDALQK EEEMEGDYQE TWKATGSRSY SPDHRQKKHR KLSELERPHK VSHGHERRDE
190 200 210 220 230 240
RKRCHRMSPT YSSDPESSDY GHVQSPPSCT SPHQMYVDHY RSLEEDQEPI VSHQKPGKGH
250 260 270 280 290 300
SNAFQDRLGA SQERHLGEPH GKGVVSQNKE HKSSHKDKRP VDAKSDEKAS VVSREKSHKA
310 320 330 340 350 360
LSKEENRRPP SGDNAREKPP SSGVKKEKDR EGSSLKKKCL PPSEAASDNH LKKPKHRDPE
370 380 390 400 410 420
KAKLDKSKQG LDSFDTGKGA GDLLPKVKEK GSNNLKTPEG KVKTNLDRKS LGSLPKVEET
430 440 450 460 470 480
DMEDEFEQPT MSFESYLSYD QPRKKKKKIV KTSATALGDK GLKKNDSKST GKNLDSVQKL
490 500 510 520 530 540
PKVNKTKSEK PAGADLAKLR KVPDVLPVLP DLPLPAIQAN YRPLPSLELI SSFQPKRKAF
550 560 570 580 590 600
SSPQEEEEAG FTGRRMNSKM QVYSGSKCAY LPKMMTLHQQ CIRVLKNNID SIFEVGGVPY
610 620 630 640 650 660
SVLEPVLERC TPDQLYRIEE YNHVLIEETD QLWKVHCHRD FKEERPEEYE SWREMYLRLQ
670 680 690 700 710 720
DAREQRLRVL TKNIQFAHAN KPKGRQAKMA FVNSVAKPPR DVRRRQEKFG TGGAAVPEKI
730 740 750 760 770 780
KIKPAPYPMG SSHASASSIS FNPSPEEPAY DGPSTSSAHL APVVSSTVSY DPRKPTVKKI
790
APMMAKTIKA FKNRFSRR