Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CAM5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CAM5-F1 | Predicted | AlphaFoldDB |
16 variants for Q8CAM5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389116337 | 36 | H>Y | No | EVA | |
| rs3389083238 | 68 | V>L | No | EVA | |
| rs3389083265 | 78 | C>* | No | EVA | |
| rs46885979 | 84 | H>R | No | EVA | |
| rs3389049304 | 90 | I>V | No | EVA | |
| rs3389117628 | 92 | V>M | No | EVA | |
| rs3389093915 | 122 | I>N | No | EVA | |
| rs3389110869 | 131 | Q>* | No | EVA | |
| rs3389102846 | 164 | C>Y | No | EVA | |
| rs3389079693 | 171 | T>S | No | EVA | |
| rs3401591270 | 177 | S>* | No | EVA | |
| rs3389106404 | 184 | A>P | No | EVA | |
| rs3389093907 | 218 | A>V | No | EVA | |
| rs220873246 | 224 | Q>K | No | EVA | |
| rs3389107929 | 258 | N>Y | No | EVA | |
| rs235884791 | 263 | G>S | No | EVA |
No associated diseases with Q8CAM5
No regional properties for Q8CAM5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8CAM5 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A6QR46 | RAB6B | Ras-related protein Rab-6B | Bos taurus (Bovine) | PR |
| Q1KME6 | RAB6A | Ras-related protein Rab-6A | Gallus gallus (Chicken) | PR |
| O18334 | Rab6 | Ras-related protein Rab6 | Drosophila melanogaster (Fruit fly) | PR |
| Q5JT25 | RAB41 | Ras-related protein Rab-41 | Homo sapiens (Human) | PR |
| Q9NRW1 | RAB6B | Ras-related protein Rab-6B | Homo sapiens (Human) | PR |
| P20340 | RAB6A | Ras-related protein Rab-6A | Homo sapiens (Human) | PR |
| Q9BZG1 | RAB34 | Ras-related protein Rab-34 | Homo sapiens (Human) | PR |
| O95755 | RAB36 | Ras-related protein Rab-36 | Homo sapiens (Human) | PR |
| P35279 | Rab6a | Ras-related protein Rab-6A | Mus musculus (Mouse) | PR |
| P61294 | Rab6b | Ras-related protein Rab-6B | Mus musculus (Mouse) | PR |
| Q8CB87 | Rab44 | Ras-related protein Rab-44 | Mus musculus (Mouse) | PR |
| Q99P58 | Rab27b | Ras-related protein Rab-27B | Mus musculus (Mouse) | PR |
| Q9ERI2 | Rab27a | Ras-related protein Rab-27A | Mus musculus (Mouse) | PR |
| Q9WVB1 | Rab6a | Ras-related protein Rab-6A | Rattus norvegicus (Rat) | PR |
| P34213 | rab-6.1 | Ras-related protein rab-6.1 | Caenorhabditis elegans | PR |
| Q22782 | rab-6.2 | Ras-related protein rab-6.2 | Caenorhabditis elegans | PR |
| O80501 | RABH1B | Ras-related protein RABH1b | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SMR4 | RABH1C | Ras-related protein RABH1c | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFT9 | RABH1E | Ras-related protein RABH1e | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LV79 | RABH1A | Ras-related protein RABH1a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRSSWTPLGP | PVSQDRIITS | FPKWYTPDAC | LQLKEHFHSR | VSTACQHRNT | GTAGLRLSKV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VVVGDLYVGK | TSLIHRLCKN | VFDHDYKATI | GVDFEIERFE | IAGIPYSLQI | WDTAGQEKFK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CIASAYYRGA | QVIITAFDLT | DVQTLEHTRQ | WLEDVLRENE | AGSCFIFLVG | TKKDLLSGAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CEQAEAEAVH | LANEMQAEYW | SVSAKTGENV | KAFFSRVAAL | AFEQSVLQDL | EKRPSTQSQV |
| 250 | 260 | ||||
| GDGDGDLIRI | EVPKTQENKR | PPGLGCC |