A6QR46
Gene name |
RAB6B |
Protein name |
Ras-related protein Rab-6B |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:526526 |
EC number |
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6QR46
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6QR46-F1 | Predicted | AlphaFoldDB |
No variants for A6QR46
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A6QR46 | |||||
No associated diseases with A6QR46
16 regional properties for A6QR46
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| ptm | EGF-type aspartate/asparagine hydroxylation site | 606 - 617 | IPR000152-1 |
| ptm | EGF-type aspartate/asparagine hydroxylation site | 768 - 779 | IPR000152-2 |
| domain | EGF-like domain | 591 - 631 | IPR000742-1 |
| domain | EGF-like domain | 753 - 793 | IPR000742-2 |
| domain | CUB domain | 340 - 477 | IPR000859-1 |
| domain | CUB domain | 478 - 591 | IPR000859-2 |
| domain | CUB domain | 634 - 753 | IPR000859-3 |
| domain | CUB domain | 797 - 909 | IPR000859-4 |
| domain | CUB domain | 910 - 1026 | IPR000859-5 |
| domain | Peptidase M12A | 136 - 338 | IPR001506 |
| domain | EGF-like calcium-binding domain | 591 - 631 | IPR001881-1 |
| domain | EGF-like calcium-binding domain | 753 - 793 | IPR001881-2 |
| domain | Peptidase, metallopeptidase | 142 - 286 | IPR006026 |
| conserved_site | EGF-like calcium-binding, conserved site | 591 - 615 | IPR018097-1 |
| conserved_site | EGF-like calcium-binding, conserved site | 753 - 777 | IPR018097-2 |
| domain | Tolloid/BMP1 peptidase domain | 137 - 338 | IPR034036 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.5.2 | Acting on GTP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| endoplasmic reticulum-Golgi intermediate compartment | A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| Golgi organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. |
| protein localization to Golgi membrane | A process in which a protein is transported to, or maintained in, a location within a Golgi membrane. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
19 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0IIG8 | RAB18 | Ras-related protein Rab-18 | Bos taurus (Bovine) | PR |
| Q8HZJ5 | RAB27B | Ras-related protein Rab-27B | Bos taurus (Bovine) | PR |
| Q1KME6 | RAB6A | Ras-related protein Rab-6A | Gallus gallus (Chicken) | PR |
| O18334 | Rab6 | Ras-related protein Rab6 | Drosophila melanogaster (Fruit fly) | PR |
| O95755 | RAB36 | Ras-related protein Rab-36 | Homo sapiens (Human) | PR |
| Q5JT25 | RAB41 | Ras-related protein Rab-41 | Homo sapiens (Human) | PR |
| P20340 | RAB6A | Ras-related protein Rab-6A | Homo sapiens (Human) | PR |
| Q9BZG1 | RAB34 | Ras-related protein Rab-34 | Homo sapiens (Human) | PR |
| Q9NRW1 | RAB6B | Ras-related protein Rab-6B | Homo sapiens (Human) | PR |
| P35279 | Rab6a | Ras-related protein Rab-6A | Mus musculus (Mouse) | PR |
| Q8CAM5 | Rab36 | Ras-related protein Rab-36 | Mus musculus (Mouse) | PR |
| P61294 | Rab6b | Ras-related protein Rab-6B | Mus musculus (Mouse) | PR |
| Q9WVB1 | Rab6a | Ras-related protein Rab-6A | Rattus norvegicus (Rat) | PR |
| P34213 | rab-6.1 | Ras-related protein rab-6.1 | Caenorhabditis elegans | PR |
| Q22782 | rab-6.2 | Ras-related protein rab-6.2 | Caenorhabditis elegans | PR |
| Q9LV79 | RABH1A | Ras-related protein RABH1a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O80501 | RABH1B | Ras-related protein RABH1b | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFT9 | RABH1E | Ras-related protein RABH1e | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SMR4 | RABH1C | Ras-related protein RABH1c | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAGGDFGNP | LRKFKLVFLG | EQSVGKTSLI | TRFMYDSFDN | TYQATIGIDF | LSKTMYLEDR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TVRLQLWDTA | GQERFRSLIP | SYIRDSTVAV | VVYDITNLNS | FQQTSKWIDD | VRTERGSDVI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IMLVGNKTDL | ADKRQITIEE | GEQRAKELSV | MFIETSAKTG | YNVKQLFRRV | ASALPGMENV |
| 190 | 200 | ||||
| QEKSKEGMID | IKLDKPQEPP | ASEGGCSC |