Q8C6G8
Gene name |
Wdr26 |
Protein name |
WD repeat-containing protein 26 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:226757 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C6G8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C6G8-F1 | Predicted | AlphaFoldDB |
21 variants for Q8C6G8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388522591 | 196 | L>Q | No | EVA | |
| rs3388520214 | 207 | G>D | No | EVA | |
| rs3388516450 | 228 | E>* | No | EVA | |
| rs3388522550 | 238 | M>T | No | EVA | |
| rs3388522542 | 242 | A>V | No | EVA | |
| rs3388522841 | 243 | E>G | No | EVA | |
| rs3388518318 | 244 | D>H | No | EVA | |
| rs3388519760 | 327 | T>I | No | EVA | |
| rs3388522441 | 338 | V>L | No | EVA | |
| rs3388516130 | 339 | W>C | No | EVA | |
| rs3391032112 | 351 | A>T | No | EVA | |
| rs3388516095 | 363 | Q>P | No | EVA | |
| rs3388523432 | 383 | G>D | No | EVA | |
| rs3388522034 | 515 | S>P | No | EVA | |
| rs3388522034 | 515 | S>T | No | EVA | |
| rs3388522850 | 516 | K>T | No | EVA | |
| rs3388519755 | 529 | G>R | No | EVA | |
| rs3388523447 | 587 | A>G | No | EVA | |
| rs3390897329 | 606 | P>L | No | EVA | |
| rs3388522842 | 618 | V>D | No | EVA | |
| rs3388524338 | 628 | D>N | No | EVA |
No associated diseases with Q8C6G8
7 regional properties for Q8C6G8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 324 - 372 | IPR001680-1 |
| repeat | WD40 repeat | 370 - 411 | IPR001680-2 |
| repeat | WD40 repeat | 414 - 454 | IPR001680-3 |
| repeat | WD40 repeat | 537 - 579 | IPR001680-4 |
| repeat | WD40 repeat | 582 - 622 | IPR001680-5 |
| domain | LIS1 homology motif | 103 - 135 | IPR006594 |
| domain | CTLH, C-terminal LisH motif | 136 - 211 | IPR006595 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| GID complex | A protein complex with ubiquitin ligase activity that is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. In S. cerevisiae, the GID (Glucose Induced degradation Deficient) complex consists of Vid30p, Rmd5p, Vid24p, Vid28p, Gid7p, Gid8p, and Fyv10p. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| ubiquitin ligase complex | A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9H7D7 | WDR26 | WD repeat-containing protein 26 | Homo sapiens (Human) | PR |
| Q28D01 | wdr26 | WD repeat-containing protein 26 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q5SP67 | wdr26 | WD repeat-containing protein 26 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQANGAGGGG | GGGGGGQGQT | PELACLSAQN | GESSPSATSA | GDLAHANGLL | PAAPSAAGNN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SNSLSVNNGV | PGGAAAASAT | AAAAQATPEL | GSSLKKKKRL | SQSDEDVIRL | IGQHLNGLGL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NQTVDLLMQE | SGCRLEHPSA | TKFRNHVMEG | DWDKAENDLN | ELKPLVHSPH | AIVVRGALEI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SQTLLGIIVR | MKFLLLQQKY | LEYLEDGKVL | EALQVLRCEL | TPLKYNTERI | HVLSGYLMCS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HAEDLRAKAE | WEGKGTASRS | KLLDKLQTYL | PPSVMLPPRR | LQTLLRQAVE | LQRDRCLYHN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TKLDNNLDSV | SLLIDHVCSR | RQFPCYTQQI | LTEHCNEVWF | CKFSNDGTKL | ATGSKDTTVI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IWQVDPDTHL | LKLLKTLEGH | AYGVSYIAWS | PDDSYLVACG | PDDCSELWLW | NVQTGELRTK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MSQSHEDSLT | SVAWNPDGKR | FVTGGQRGQF | YQCDLDGNLL | DSWEGVRVQC | LWCLSDGKTV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LASDTHQRVR | GYNFEDLTDR | NIVQEDHPIM | SFTISKNGRL | ALLNVATQGV | HLWDLQDRVL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VRKYQGVTQG | FYTIHSCFGG | HNEDFIASGS | EDHKVYIWHK | RSELPIAELT | GHTRTVNCVS |
| 610 | 620 | 630 | 640 | ||
| WNPQIPSMMA | SASDDGTVRI | WGPAPFIDHQ | NIEEECSSMD | S |