Q8C4U2

PR
Gene name
Tmem145
Protein name
Transmembrane protein 145
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:330485
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

475-546 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8C4U2

Entry ID Method Resolution Chain Position Source
AF-Q8C4U2-F1 Predicted AlphaFoldDB

No variants for Q8C4U2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8C4U2

No associated diseases with Q8C4U2

1 regional properties for Q8C4U2

Type Name Position InterPro Accession
domain Intimal thickness related receptor, IRP 158 - 411 IPR019336

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
response to pheromone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q61205 Pafah1b3 Platelet-activating factor acetylhydrolase IB subunit alpha1 Mus musculus (Mouse) PR
O35263 Pafah1b3 Platelet-activating factor acetylhydrolase IB subunit alpha1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MEPSRAPVLG RLLPPLLLLL LPLYPRTRAK YVRGNLSSKE DWVFLTRFCF LSDYGRLDFR
70 80 90 100 110 120
FRYPEAKCCQ NILLYFDDPS QWPAVYKARD KDCLAKESVI RPENNQVINL TTQYAWSGCQ
130 140 150 160 170 180
VVSEEGTRYL SCSSGRSFRS VRERWWYIAL SKCGGDGLQL EYEMVLTNGK SFWTRHFSAD
190 200 210 220 230 240
EFGILETDVT FLLIFTLIFV LSCYFGYLLK GRQLLHTTYK MFMAAAGVEV LSLLFFCIYW
250 260 270 280 290 300
GQYATDGIGN GSVKILAKLL FSSSFLIFLL TLILLGKGFT VTRGRISHSG SVKLSVYMTL
310 320 330 340 350 360
YTLTHVVLLI YEAEFFDPGQ VLYTYESPAG YGLIGLQVAA YVWFCYAVLV SLRHYPEKQP
370 380 390 400 410 420
FYVPFFAAYT LWFFAVPVMA LIANFGIPKW AREKIVNGIQ LGIHLYAHGV FLIMTRPSAA
430 440 450 460 470 480
NKNFPYHVRT SQIASAGVPG PGGSQSADKA FPQHVYGNVT FISDSVPNFT ELFSIPPPTS
490 500 510 520 530 540
SAGKQVEETA VAAAVAPRGR VVTMAEPGAA SPPPPARFSK AVHSGWDGPT PSYQPLVPPE
550 560 570 580 590 600
QRRGKPASPN TSACTQPGAL HPRSEHPFPA SAPRAAHRAP AGLRNPVSLP AQGLGHARHP
610 620 630 640 650 660
APLPHPAPTL DALRPAPFPL VPNGPAGAVL RVPSLSPCPE WLRNLDSRCS VISAPLTPFE
670 680 690 700 710 720
TSDPAGLRNT RDDRLDPARP SRTLRPSSHC LETDIVKLVS TLKPSLGFVT SDLCFVRPSE
730 740
CQGPSHGLWQ KDVFSSCQNK EDSLSF