Q61205

PR
Gene name
Pafah1b3
Protein name
Platelet-activating factor acetylhydrolase IB subunit alpha1
Names
PAF acetylhydrolase 29 kDa subunit, PAF-AH 29 kDa subunit, PAF-AH subunit gamma, PAFAH subunit gamma
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:18476
EC number
3.1.1.47: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q61205

Entry ID Method Resolution Chain Position Source
AF-Q61205-F1 Predicted AlphaFoldDB

9 variants for Q61205

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388889884 38 K>N No EVA
rs3388889381 40 P>A No EVA
rs3388887297 41 E>D No EVA
rs3413076187 127 K>N No EVA
rs3397525943 129 Q>R No EVA
rs3388872098 156 V>I No EVA
rs3397525981 216 L>P No EVA
rs3397436976 219 Q>L No EVA
rs3388872094 233 S>K No EVA

No associated diseases with Q61205

1 regional properties for Q61205

Type Name Position InterPro Accession
domain SGNH hydrolase-type esterase domain 44 - 202 IPR013830

Functions

Description
EC Number 3.1.1.47 Carboxylic ester hydrolases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
1-alkyl-2-acetylglycerophosphocholine esterase complex An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF).
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

6 GO annotations of molecular function

Name Definition
1-alkyl-2-acetylglycerophosphocholine esterase activity Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
identical protein binding Binding to an identical protein or proteins.
platelet-activating factor acetyltransferase activity Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein-containing complex binding Binding to a macromolecular complex.

3 GO annotations of biological process

Name Definition
brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8C4U2 Tmem145 Transmembrane protein 145 Mus musculus (Mouse) PR
O35263 Pafah1b3 Platelet-activating factor acetylhydrolase IB subunit alpha1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MSGEGENPAS KPTPVQDVQG DGRWMSLHHR FVADSKDKEP EVVFIGDSLV QLMHQCEIWR
70 80 90 100 110 120
ELFSPLHALN FGIGGDSTQH VLWRLENGEL EHIRPKIVVV WVGTNNHSHT AEQVTGGIKA
130 140 150 160 170 180
IVQLVNKLQP QARVVVLGLL PRGQHPNPLR EKNRQVNELV RAALAGYPRA HFLDADPGFV
190 200 210 220 230
HSDGTISHHD MYDYLHLSRL GYTPVCRALH SLLLRLLAQD QGQGIPLPET AS