Q8C428

PR
Gene name
Tmc7
Protein name
Transmembrane channel-like protein 7
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:209760
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8C428

Entry ID Method Resolution Chain Position Source
AF-Q8C428-F1 Predicted AlphaFoldDB

36 variants for Q8C428

Variant ID(s) Position Change Description Diseaes Association Provenance
rs231075780 11 H>Y No EVA
rs251426564 23 N>T No EVA
rs3388925443 45 R>Q No EVA
rs3388945173 57 R>W No EVA
rs3388939626 68 T>S No EVA
rs32494165 73 C>S No EVA
rs3388945862 112 L>F No EVA
rs3388913561 114 E>* No EVA
rs32495906 200 V>L No EVA
rs3388920197 220 G>V No EVA
rs3388939862 221 L>I No EVA
rs3388940910 239 E>D No EVA
rs3388940879 243 L>P No EVA
rs3388920166 244 F>L No EVA
rs3398475640 247 H>N No EVA
rs3398506797 251 D>N No EVA
rs3398411380 301 Q>L No EVA
rs3388934881 319 S>T No EVA
rs3388939639 348 R>S No EVA
rs32489156 358 T>S No EVA
rs3388944629 360 R>M No EVA
rs3388940889 370 V>E No EVA
rs3388929843 387 E>D No EVA
rs3388913585 437 E>G No EVA
rs3413141803 441 T>K No EVA
rs3388944668 462 S>F No EVA
rs3398054406 563 P>PFLTSFT* No EVA
rs3388943356 566 A>T No EVA
rs3388920168 637 T>A No EVA
rs3398411373 649 F>Y No EVA
rs3398683727 651 S>RWC* No EVA
rs3388899038 654 Q>H No EVA
rs3388899095 660 V>F No EVA
rs3388920150 688 K>M No EVA
rs3388939656 709 I>N No EVA
rs3388939641 722 Q>H No EVA

No associated diseases with Q8C428

1 regional properties for Q8C428

Type Name Position InterPro Accession
domain TMC domain 484 - 595 IPR012496

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
mechanosensitive ion channel activity Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7Z402 TMC7 Transmembrane channel-like protein 7 Homo sapiens (Human) PR
Q7TN58 Tmc8 Transmembrane channel-like protein 8 Mus musculus (Mouse) PR
Q8R4P5 Tmc1 Transmembrane channel-like protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSEGSAGDPG HGSSRQRAVH PENLSLGSSC FSPPVNFLQE LPSYRSVARR RTNILSRDKQ
70 80 90 100 110 120
SGTLLKPTDS FSCQLDGGIT ENLNSQSIRK YALNISEKRR LRDIQETQMK YLSEWDQWKR
130 140 150 160 170 180
YSSKSWKRFL EKAREMTTHL ELWRKDIRSI EGKFGTGIQS YFSFLRFLVV LNLVIFLIIF
190 200 210 220 230 240
MLVLLPILLT KYKITNSTFV LIPFKDMDIQ CTLYPISSSG LIYFYSYIID LLSGTGFLEE
250 260 270 280 290 300
TSLFYGHYTI DGVKFQSFTY DLPLAYLIST IAYLALSLLW IVKRSVEGFK INLIRSEEHF
310 320 330 340 350 360
QSYCNKIFAG WDFCITNRSM AELKHSSLRY ELRADLEEER IRQKIAERTS EETIRIYTLR
370 380 390 400 410 420
LFLNCIVLAV LAACFYAIYL ATAFSQEHMK KEIDKMVFGE NLLILYLPSI VITLANFITP
430 440 450 460 470 480
IIFAKIIHYE DYSPGFEIRL TILRCVFMRL ATICVLVFTL GSKITSCGDS TCELCGYNQK
490 500 510 520 530 540
LYPCWETQVG QEMYKLMIFD FIIILAVTLF VDFPRKLLVT YCASSKLIQC WGQQEFAIPD
550 560 570 580 590 600
NVLGIVYGQT ICWIGAFFSP LLPAIATLKF VIIFYVKELS LLYTCRPSPR QFRASNSNFF
610 620 630 640 650 660
FLLVLLIGLC LAIIPLTISM ARIPSSKACG PFTNFNTTWE VIPQTVSTFP SSLQTLIHAV
670 680 690 700 710 720
TSEAFAVPFF MIICLVMFYF IALAGAHKQV VVQLREQLSL ESRDKRYLIQ KLTEAQREVR
SQPASA