AiPD: Autoinhibited Protein Database

Gene name	Tmc8 (Ever2)
Protein name	Transmembrane channel-like protein 8
Names	Epidermodysplasia verruciformis protein 2 homolog
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:217356
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-57 (Predicted disordered autoinhibitory region) PR

1-57 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q7TN58-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs1134447310	7	V>M	No	EVA
rs237176835	18	S>P	No	EVA
rs257820219	76	V>M	No	EVA
rs214633597	140	V>I	No	EVA
rs3389219803	152	K>E	No	EVA
rs248301031	154	R>S	No	EVA
rs263763065	159	S>G	No	EVA
rs3389224015	164	Q>H	No	EVA
rs241350745	195	A>V	No	EVA
rs3389236098	215	V>I	No	EVA
rs212272399	239	G>S	No	EVA
rs3389216744	249	K>I	No	EVA
rs3389216735	271	I>T	No	EVA
rs224384655	284	R>H	No	EVA
rs240177927	285	V>M	No	EVA
rs3389221646	292	T>A	No	EVA
rs3413061716	361	V>D	No	EVA
rs3389195763	386	L>M	No	EVA
rs3389209186	392	F>S	No	EVA
rs3389232888	424	E>G	No	EVA
rs28259561	460	F>C	No	EVA
rs3389155464	473	F>I	No	EVA
rs3389223974	484	A>V	No	EVA
rs3389216420	504	S>N	No	EVA
rs3389183304	557	I>N	No	EVA
rs28259556	614	V>I	No	EVA
rs3389216729	622	S>F	No	EVA
rs3389231024	628	A>T	No	EVA
rs3389155532	651	S>L	No	EVA
rs3389221293	674	F>S	No	EVA
rs28259550	685	G>D	No	EVA

Type	Name	Position	InterPro Accession
domain	Terpene synthase, N-terminal domain	278 - 485	IPR001906
domain	Terpene synthase, metal-binding domain	528 - 790	IPR005630
domain	Terpene cyclase-like 1, C-terminal domain	523 - 849	IPR034741

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

Name	Definition
mechanosensitive ion channel activity	Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress.
protein sequestering activity	Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
tumor necrosis factor binding	Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.

Name	Definition
negative regulation of protein binding	Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
negative regulation of protein-containing complex assembly	Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.
regulation of cell growth	Any process that modulates the frequency, rate, extent or direction of cell growth.
regulation of extrinsic apoptotic signaling pathway via death domain receptors	Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
zinc ion homeostasis	Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8IU68	TMC8	Transmembrane channel-like protein 8	Homo sapiens (Human)	PR
Q8C428	Tmc7	Transmembrane channel-like protein 7	Mus musculus (Mouse)	PR
Q8R4P5	Tmc1	Transmembrane channel-like protein 1	Mus musculus (Mouse)	PR