Q8C1C8
Gene name |
Pnma1 (Ma1) |
Protein name |
Paraneoplastic antigen Ma1 homolog |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70481 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C1C8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C1C8-F1 | Predicted | AlphaFoldDB |
15 variants for Q8C1C8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389247138 | 8 | D>E | No | EVA | |
| rs3389246847 | 61 | A>V | No | EVA | |
| rs3403105164 | 69 | T>P | No | EVA | |
| rs3389249085 | 84 | K>R | No | EVA | |
| rs6377584 | 100 | V>D | No | EVA | |
| rs225730202 | 107 | L>I | No | EVA | |
| rs3389259672 | 120 | A>D | No | EVA | |
| rs3389258219 | 121 | R>S | No | EVA | |
| rs263793467 | 134 | P>S | No | EVA | |
| rs47322681 | 190 | E>Q | No | EVA | |
| rs6375497 | 223 | A>G | No | EVA | |
| rs6375497 | 223 | A>V | No | EVA | |
| rs3402806247 | 255 | Q>K | No | EVA | |
| rs3403526312 | 256 | N>S | No | EVA | |
| rs3389249040 | 262 | S>F | No | EVA |
No associated diseases with Q8C1C8
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| inflammatory response to antigenic stimulus | An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UL42 | PNMA2 | Paraneoplastic antigen Ma2 | Homo sapiens (Human) | PR |
| Q9H0W5 | CCDC8 | Coiled-coil domain-containing protein 8 | Homo sapiens (Human) | PR |
| Q8BHK0 | Pnma2 | Paraneoplastic antigen Ma2 homolog | Mus musculus (Mouse) | PR |
| Q8VHZ4 | Pnma1 | Paraneoplastic antigen Ma1 homolog | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAMTLLEDWC | RGMDVNSQRA | LLVWGIPVNC | DETEIEETLQ | AAMPQVSYRV | LGRMFWREEN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AKAALLELTG | AVDYSLIPRE | MPGKGGLWKV | VFKPPTSDAV | FLERLHLFLA | REGWTVQDVA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RVLGFQNPAP | APGPEMPAEM | LNYILDNVIQ | PLVESIWYKK | LTLFSGKDIP | GPGEETFDSW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LEHSNEIIEE | WQVSDIEKRR | RLMESLRGPA | ADVIRILKTN | NAAITTAECL | KALEQVFGSV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ESSRDAQVRF | LNTYQNPGEK | LSSYVIRLEP | LLQKVVDKGV | IDKDNVNQAR | LEQVIAGANH |
| 310 | 320 | 330 | 340 | 350 | |
| SGALRRQLWL | AGAEEGPAPN | LFQLLVQIRE | EEAKKEEEEA | EAALLQLGLE | GHF |