AiPD: Autoinhibited Protein Database

Gene name	Gpcpd1 (Gde5, Kiaa1434, Prei4)
Protein name	Glycerophosphocholine phosphodiesterase GPCPD1
Names	Glycerophosphodiester phosphodiesterase 5, Preimplantation protein 4
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:74182
EC number	3.1.4.2: Phosphoric diester hydrolases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

125-224 (Predicted disordered autoinhibitory region) PR

125-224 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8C0L9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3412992119	9	E>V	No	EVA
rs3388594065	14	L>P	No	EVA
rs3388581111	32	W>L	No	EVA
rs3388594287	140	S>F	No	EVA
rs3388589683	142	K>T	No	EVA
rs3388594056	151	K>R	No	EVA
rs245152687	170	E>D	No	EVA
rs3388594353	183	H>R	No	EVA
rs3392096626	208	C>W	No	EVA
rs3388586899	244	H>Y	No	EVA
rs3388592897	247	Q>*	No	EVA
rs3388591183	256	G>D	No	EVA
rs3388597984	262	S>F	No	EVA
rs3392220413	310	S>WFPILGK*	No	EVA
rs3388586817	398	I>L	No	EVA
rs3388589688	399	P>T	No	EVA
rs3388596041	407	Q>H	No	EVA
rs1132428427	411	L>F	No	EVA
rs3388597949	462	K>R	No	EVA
rs3392150487	478	T>K	No	EVA
rs3392095774	480	F>V	No	EVA
rs3388594315	490	L>F	No	EVA
rs3388596221	495	E>K	No	EVA
rs1135037925	536	P>S	No	EVA
rs1132733650	546	T>K	No	EVA
rs1132408313	547	P>H	No	EVA
rs1132679485	549	A>E	No	EVA
rs1133412819	552	F>L	No	EVA
rs1133753193	552	F>Y	No	EVA
rs3388594328	558	I>N	No	EVA
rs13464960	602	K>E	No	EVA
rs3388596006	629	Q>K	No	EVA
rs3388594074	631	E>G	No	EVA
rs3388594809	649	S>C	No	EVA
rs3392294068	661	D>G	No	EVA
rs3388594403	668	G>C	No	EVA

Type	Name	Position	InterPro Accession
domain	Carbohydrate binding module family 20	1 - 115	IPR002044
domain	Glycerophosphodiester phosphodiesterase domain	321 - 621	IPR030395
domain	Glycerophosphocholine phosphodiesterase GPCPD1, CBM20 domain	4 - 127	IPR034839

		Description
EC Number	3.1.4.2	Phosphoric diester hydrolases
Subcellular Localization	Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Name	Definition
glycerophosphocholine phosphodiesterase activity	Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline.
glycerophosphodiester phosphodiesterase activity	Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate.
starch binding	Binding to starch.

Name	Definition
glycerophospholipid catabolic process	The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
skeletal muscle tissue development	The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q02979	GDE1	Glycerophosphocholine phosphodiesterase GDE1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9NPB8	GPCPD1	Glycerophosphocholine phosphodiesterase GPCPD1	Homo sapiens (Human)	PR