Q02979

PR
Gene name
GDE1
Protein name
Glycerophosphocholine phosphodiesterase GDE1
Names
Glycerophosphodiester phosphodiesterase GDE1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPL110C
EC number
3.1.4.2: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

92-185 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q02979

Entry ID Method Resolution Chain Position Source
AF-Q02979-F1 Predicted AlphaFoldDB

58 variants for Q02979

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-344716 8 A>V No SGRP
s16-344689 17 S>N No SGRP
s16-344681 20 V>L No SGRP
s16-344588 51 G>S No SGRP
s16-344570 57 M>V No SGRP
s16-344508 77 L>F No SGRP
s16-344506 78 A>G No SGRP
s16-344468 91 V>I No SGRP
s16-344362 126 A>V No SGRP
s16-344344 132 V>A No SGRP
s16-344323 139 K>R No SGRP
s16-344225 172 A>T No SGRP
s16-344132 203 V>F No SGRP
s16-344112 209 M>I No SGRP
s16-344072 223 N>D No SGRP
s16-344011 243 F>S No SGRP
s16-343958 261 A>S No SGRP
s16-343921 273 V>A No SGRP
s16-343826 305 V>I No SGRP
s16-343762 326 P>L No SGRP
s16-343682 353 K>E No SGRP
s16-343627 371 S>N No SGRP
s16-343573 389 P>L No SGRP
s16-343549 397 E>G No SGRP
s16-343508 411 E>K No SGRP
s16-343340 467 A>T No SGRP
s16-343289 484 A>S No SGRP
s16-343218 507 L>F No SGRP
s16-343156 528 R>K No SGRP
s16-343058 561 N>D No SGRP
s16-343043 566 E>K No SGRP
s16-342943 599 F>S No SGRP
s16-342887 618 H>D No SGRP
s16-342885 618 H>Q No SGRP
s16-342854 629 D>H No SGRP
s16-342820 640 N>I No SGRP
s16-342599 714 S>P No SGRP
s16-342371 790 I>V No SGRP
s16-342334 802 A>G No SGRP
s16-342268 824 G>D No SGRP
s16-342269 824 G>S No SGRP
s16-342265 825 S>N No SGRP
s16-342088 884 N>I No SGRP
s16-342061 893 E>G No SGRP
s16-341843 966 P>S No SGRP
s16-341807 978 K>Q No SGRP
s16-341804 979 Y>H No SGRP
s16-341775 988 D>E No SGRP
s16-341745 998 L>F No SGRP
s16-341742 999 H>Q No SGRP
s16-341734 1002 D>G No SGRP
s16-341719 1007 S>F No SGRP
s16-341711 1010 A>S No SGRP
s16-341699 1014 D>N No SGRP
s16-341630 1037 I>V No SGRP
s16-341345 1132 E>K No SGRP
s16-341212 1176 S>F No SGRP
s16-341086 1218 T>I No SGRP

No associated diseases with Q02979

7 regional properties for Q02979

Type Name Position InterPro Accession
repeat Ankyrin repeat 301 - 330 IPR002110-1
repeat Ankyrin repeat 427 - 456 IPR002110-2
repeat Ankyrin repeat 472 - 500 IPR002110-3
repeat Ankyrin repeat 503 - 533 IPR002110-4
repeat Ankyrin repeat 538 - 634 IPR002110-5
domain SPX domain 1 - 213 IPR004331
domain Glycerophosphodiester phosphodiesterase domain 872 - 1217 IPR030395

Functions

Description
EC Number 3.1.4.2 Phosphoric diester hydrolases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
glycerophosphocholine phosphodiesterase activity Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline.
glycerophosphoinositol glycerophosphodiesterase activity Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = sn-glycerol 3-phosphate + myo-inositol + H(+).

1 GO annotations of biological process

Name Definition
glycerophospholipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NPB8 GPCPD1 Glycerophosphocholine phosphodiesterase GPCPD1 Homo sapiens (Human) PR
Q8C0L9 Gpcpd1 Glycerophosphocholine phosphodiesterase GPCPD1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MKFGKTFANH RIPEWSSQYV GYKSLKKMIK EITRLQEDIY RAHNKNSYDE GRPPTKMRDS
70 80 90 100 110 120
SNSAQNYLDS PKIQKLLASF FFAVDRDIEK VDTFYNSQYA EYKKRFERLL SSNQFNEIKS
130 140 150 160 170 180
TLVVDANKED AVAQTLLTKD TREMNMLLKG TSQASRLSYH KDDLIEIQSI LAELRKQFRN
190 200 210 220 230 240
LKWYAELNKR AFGKILKKLD KKVGTNQQMS TMKTRILPLQ FANDSLITKD LSLLKTIWEQ
250 260 270 280 290 300
VTFRINSYER VMRSTSPNAN ANDNTEFFKI ICVFIEEDDS KGLIRELTNL YSELSLIPTR
310 320 330 340 350 360
IMISVLNKAA LSKSLACIDA ILKVIPSLND SEDINRRNFF HHHIIAIGKL IRKQEILSRK
370 380 390 400 410 420
KKSQPSKYTN SEGEIVTDLR TLHTTLSAPA ESDSITEEEK SSACTLSYIL EELPIHLRPC
430 440 450 460 470 480
LFQHDNYKRT PLHYSCQYGL SEVTKLIIKL MKEWNIWNEI PIDDVSAFGD AESLTPLHLC
490 500 510 520 530 540
VLGAHPKTTE VLLQSLDPNV KLKSSSLLHL ATEWNNYPLL HVLLSSKRFD INYQDNELHE
550 560 570 580 590 600
TPLYLACRLN FFEAAVCLLY NGADLEIREK LFGWTAIFVA AAEGFTDIVK LLIANNANFD
610 620 630 640 650 660
IEDEGGWTPM EHAVLRGHLH IADMVQIRDE LVTHPHSQLN SGSEEKEPLN EISAGELNER
670 680 690 700 710 720
NENGNGGNKG SLGKLAGPIK SYGHRFLDNN ESLILITLGS NDTRNKSPSI SLSSEALAKV
730 740 750 760 770 780
IGLETDCALS LVISCNDSID KSSVILDLPL DDNVDAVDFK VPFKVDYSHT LYFDIVPTYG
790 800 810 820 830 840
TRSLETHNRI DCQKNNNNYV MARGVSMLNK SYSSVGVNRS ILNGSVTVPI IANHTLEILG
850 860 870 880 890 900
TLKFEYIIIT PFEHPQLPLE RTETYWKSLV STRVIGHRGL GKNNPNKSLQ IGENTVESFI
910 920 930 940 950 960
MAASLGASYV EFDVQLTKDN VPVVYHDFLV AETGVDIPMH ELTLEQFLDL NNADKEHIQR
970 980 990 1000 1010 1020
GAGHSPHHVN GADTALQKYR GRSVDDSDVS TLRRAWDLHD NDPNGKSNNA HWSDNRMRLT
1030 1040 1050 1060 1070 1080
KTFKKNNFKG NARGHSIASS FVTLKELFKK IPANVGFNIE CKFPMLDEAE EEELGQIMME
1090 1100 1110 1120 1130 1140
MNHWVDTVLK VVFDNANGRD IIFSSFHPDI CIMLSLKQPV IPILFLTEGG SEQMADLRAS
1150 1160 1170 1180 1190 1200
SLQNGIRFAK KWNLLGIVSA AAPILKAPRL VQVVKSNGLV CVTYGVDNND PENASIQIEA
1210 1220
GVDAVIVDSV LAIRRGLTKK NEK