AiPD: Autoinhibited Protein Database

Gene name	Cog5
Protein name	Conserved oligomeric Golgi complex subunit 5
Names	COG complex subunit 5, Component of oligomeric Golgi complex 5
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:238123
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-43 (Predicted disordered autoinhibitory region) PR

1-43 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8C0L8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs108064249	27	A>T	No	EVA
rs3389233804	95	S>T	No	EVA
rs3389204220	128	I>K	No	EVA
rs3389250099	176	L>I	No	EVA
rs3389235232	223	Q>*	No	EVA
rs3403239635	224	N>I	No	EVA
rs3403294595	227	Q>L	No	EVA
rs3402733373	229	G>F*	No	EVA
rs3402733373	230	T>F	No	EVA
rs107685213	243	E>D	No	EVA
rs3412733115	243	E>K	No	EVA
rs3389210671	258	D>N	No	EVA
rs3389250120	287	P>L	No	EVA
rs3389245884	291	S>R	No	EVA
rs3389204144	292	T>P	No	EVA
rs3403059722	326	K>M	No	EVA
rs3389243235	328	R>I	No	EVA
rs3389197715	331	V>F	No	EVA
rs3389239506	374	L>M	No	EVA
rs3403220998	394	K>R	No	EVA
rs3389233822	403	T>I	No	EVA
rs246699891	414	D>E	No	EVA
rs107660655	416	C>Y	No	EVA
rs3403193582	418	D>E	No	EVA
rs3402473571	419	L>V	No	EVA
rs3401842212	422	M>I	No	EVA
rs3403193624	422	M>R	No	EVA
rs108335153	431	R>I	No	EVA
rs108603114	531	D>E	No	EVA
rs3389250169	562	K>E	No	EVA
rs3389237835	569	S>L	No	EVA
rs3389222615	581	A>V	No	EVA
rs3389210603	604	I>S	No	EVA
rs3389237812	610	T>I	No	EVA
rs108059088	621	S>T	No	EVA
rs3389235192	622	S>N	No	EVA
rs3389210633	637	L>I	No	EVA
rs3389167471	639	G>C	No	EVA
rs108665130	735	D>E	No	EVA
rs3389243243	743	I>K	No	EVA
rs107870691	748	I>V	No	EVA
rs108862309	762	S>A	No	EVA
rs3389229037	768	E>*	No	EVA
rs3413090578	772	A>D	No	EVA
rs3389237765	786	D>N	No	EVA
rs3389204133	797	A>V	No	EVA
rs3389237797	819	Q>H	No	EVA

Type	Name	Position	InterPro Accession
domain	Oxoglutarate/iron-dependent dioxygenase	77 - 175	IPR005123
domain	Prolyl 4-hydroxylase, alpha subunit	1 - 174	IPR006620
domain	PKHD-type hydroxylase C-terminal domain	181 - 221	IPR041097
domain	Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain	90 - 173	IPR044862

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Golgi apparatus membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
Golgi transport complex	A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

Name	Definition
No GO annotations for molecular function

Name	Definition
glycosylation	The covalent attachment and further modification of carbohydrate residues to a substrate molecule.
Golgi organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
inter-Golgi cisterna vesicle-mediated transport	The directed movement of substances from one Golgi cisterna to another, mediated by small transport vesicles.
intra-Golgi vesicle-mediated transport	The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
retrograde transport, vesicle recycling within Golgi	The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9UP83	COG5	Conserved oligomeric Golgi complex subunit 5	Homo sapiens (Human)	PR