Q8BZN6
PR
Gene name |
Dock10 |
Protein name |
Dedicator of cytokinesis protein 10 |
Names |
Zizimin-3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:210293 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q8BZN6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 8I5F | X-ray | 280 A | A/B | 1664-2150 | PDB |
| 8I5V | X-ray | 173 A | A | 1875-2150 | PDB |
| 8I5W | X-ray | 243 A | A | 1875-2150 | PDB |
| AF-Q8BZN6-F1 | Predicted | AlphaFoldDB |
94 variants for Q8BZN6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388484730 | 51 | L>W | No | EVA | |
| rs3388481927 | 66 | D>Y | No | EVA | |
| rs259481387 | 88 | D>N | No | EVA | |
| rs3388484644 | 141 | E>* | No | EVA | |
| rs3388482148 | 153 | E>K | No | EVA | |
| rs3388481460 | 155 | D>N | No | EVA | |
| rs3388484681 | 172 | K>E | No | EVA | |
| rs3388482667 | 174 | G>R | No | EVA | |
| rs3388482201 | 179 | G>S | No | EVA | |
| rs3388484550 | 190 | K>M | No | EVA | |
| rs3388481397 | 204 | R>W | No | EVA | |
| rs3388482682 | 206 | F>Y | No | EVA | |
| rs3388482899 | 220 | S>C | No | EVA | |
| rs3388480189 | 224 | N>K | No | EVA | |
| rs3390164326 | 236 | K>* | No | EVA | |
| rs3390247624 | 236 | K>M | No | EVA | |
| rs3388482092 | 237 | G>S | No | EVA | |
| rs3388481518 | 240 | F>L | No | EVA | |
| rs3388482494 | 244 | C>S | No | EVA | |
| rs3388482425 | 300 | R>S | No | EVA | |
| rs3388482786 | 318 | T>A | No | EVA | |
| rs3388482759 | 326 | T>K | No | EVA | |
| rs3406008039 | 333 | L>Q | No | EVA | |
| rs3390090816 | 334 | H>L | No | EVA | |
| rs3390247646 | 335 | P>H | No | EVA | |
| rs3390247655 | 336 | D>Y | No | EVA | |
| rs49168465 | 355 | G>D | No | EVA | |
| rs32279115 | 376 | S>I | No | EVA | |
| rs3390237333 | 378 | E>Q | No | EVA | |
| rs3388482417 | 423 | F>L | No | EVA | |
| rs3388480171 | 445 | D>N | No | EVA | |
| rs219007990 | 449 | P>S | No | EVA | |
| rs3388482691 | 450 | A>T | No | EVA | |
| rs215049530 | 476 | E>D | No | EVA | |
| rs3388481211 | 478 | P>H | No | EVA | |
| rs3388482726 | 486 | E>D | No | EVA | |
| rs3388483259 | 521 | S>R | No | EVA | |
| rs3388482753 | 531 | D>E | No | EVA | |
| rs3388482910 | 562 | R>S | No | EVA | |
| rs3388482356 | 580 | P>Q | No | EVA | |
| rs3388482978 | 588 | K>E | No | EVA | |
| rs3388480995 | 620 | A>T | No | EVA | |
| rs3388482160 | 621 | V>M | No | EVA | |
| rs30209331 | 645 | S>T | No | EVA | |
| rs3390229214 | 672 | K>I | No | EVA | |
| rs3390225298 | 674 | Q>* | No | EVA | |
| rs3390247653 | 674 | Q>L | No | EVA | |
| rs3390229234 | 676 | Y>F | No | EVA | |
| rs3388482119 | 718 | G>A | No | EVA | |
| rs3388481057 | 724 | L>I | No | EVA | |
| rs3388482118 | 888 | N>K | No | EVA | |
| rs3388481859 | 892 | V>M | No | EVA | |
| rs3388482098 | 905 | I>F | No | EVA | |
| rs237958302 | 923 | A>S | No | EVA | |
| rs214506126 | 925 | V>I | No | EVA | |
| rs3388481344 | 991 | W>C | No | EVA | |
| rs3388482755 | 1039 | I>S | No | EVA | |
| rs3388484604 | 1060 | L>I | No | EVA | |
| rs3413118954 | 1068 | D>* | No | EVA | |
| rs223099307 | 1078 | N>S | No | EVA | |
| rs1134893493 | 1198 | Q>K | No | EVA | |
| rs1134359881 | 1200 | Q>* | No | EVA | |
| rs1134359539 | 1205 | Y>* | No | EVA | |
| rs1131980871 | 1209 | Y>* | No | EVA | |
| rs1132259088 | 1235 | G>V | No | EVA | |
| rs1133995438 | 1239 | D>Y | No | EVA | |
| rs3390237348 | 1253 | K>N | No | EVA | |
| rs3388482747 | 1258 | V>M | No | EVA | |
| rs3390207548 | 1270 | I>L | No | EVA | |
| rs3390257480 | 1270 | I>T | No | EVA | |
| rs3388482061 | 1390 | K>E | No | EVA | |
| rs30205362 | 1405 | G>R | No | EVA | |
| rs3388482350 | 1473 | V>A | No | EVA | |
| rs3388482040 | 1482 | I>V | No | EVA | |
| rs256849168 | 1498 | T>I | No | EVA | |
| rs3390236198 | 1558 | A>D | No | EVA | |
| rs30207844 | 1568 | V>I | No | EVA | |
| rs222559655 | 1600 | Q>H | No | EVA | |
| rs3388481485 | 1637 | N>I | No | EVA | |
| rs3388481887 | 1638 | F>L | No | EVA | |
| rs1135142673 | 1735 | K>* | No | EVA | |
| rs1132726783 | 1736 | R>C | No | EVA | |
| rs3388480921 | 1812 | Q>L | No | EVA | |
| rs3388481424 | 1895 | E>D | No | EVA | |
| rs3388481860 | 1895 | E>K | No | EVA | |
| rs3388484593 | 1923 | A>T | No | EVA | |
| rs3388480150 | 1923 | A>V | No | EVA | |
| rs3388481264 | 1950 | T>I | No | EVA | |
| rs3388483321 | 2025 | E>* | No | EVA | |
| rs3388482210 | 2125 | E>G | No | EVA | |
| rs3388481550 | 2131 | R>G | No | EVA | |
| rs247305044 | 2150 | T>M | No | EVA | |
| rs3388482737 | 2151 | G>D | No | EVA | |
| rs51400299 | 2174 | A>V | No | EVA |
No associated diseases with Q8BZN6
8 regional properties for Q8BZN6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pleckstrin homology domain | 181 - 292 | IPR001849 |
| domain | Dedicator of cytokinesis C/D, N-terminal | 46 - 155 | IPR021816 |
| domain | C2 DOCK-type domain | 670 - 859 | IPR027007 |
| domain | DOCKER domain | 1690 - 2150 | IPR027357 |
| domain | Dedicator of cytokinesis D, C2 domain | 671 - 860 | IPR037809 |
| domain | DOCKER, Lobe A | 1683 - 1864 | IPR046769 |
| domain | DOCKER, Lobe B | 1932 - 2007 | IPR046770 |
| domain | DOCKER, Lobe C | 2042 - 2143 | IPR046773 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendritic spine | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| small GTPase binding | Binding to a small monomeric GTPase. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| B cell homeostasis | The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. |
| dendritic spine morphogenesis | The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. |
| marginal zone B cell differentiation | The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL). |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| regulation of cell migration | Any process that modulates the frequency, rate or extent of cell migration. |
| small GTPase mediated signal transduction | The series of molecular signals in which a small monomeric GTPase relays a signal. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGERTRRFT | RSLLRPGQAA | ELRHSAASAA | AVAVSSRQQQ | RQEKPRLLDP | LDYETVIEEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKTYRDDPLQ | DLLFFPSDDF | STATVSWDIR | TLYSTVPEEA | EHRAESLLVK | EACKFYSSQW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YVVNYKYEQY | SGDIRQLPRA | EHKPEKLPSH | SFEVDHEDAD | KDEDTTSHSS | SKGGGGAGGT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GVFKSGWLYK | GNFNSTVNNT | VTVRSFKKRY | FQLTQLPDNS | YIMNFYKDEK | ISKEPKGCIF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDSCTGVVQN | NRLRKYAFEL | KMNDLTYFVL | AAETESDMDE | WIHTLNRILQ | ISPEGPLQGR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KSAELAELGL | DPLDNCVTCE | CTLEETDSSE | NSLHPDFAKY | LTETEDTVKT | TRNMGRLNLF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SLDPDIDTLK | LQKRDSFENE | LMIKPFEEKA | AKRIMIICRA | LNFNLQGCVT | ENEYDPVTNI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EPFFVSVALY | DLRDNRKISA | DFHVDLNHPA | VRQMLSGTPP | ALENGNIDTG | TPRQSEEPHI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KGLPEEWLKF | PKQAVFSVSD | PHSEIVLVAK | VEKVLMGNIG | SGAEPYIKNP | DSNKFAQKIL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KSNRQFCSKL | GKYRMPFAWA | VRSVFKDNQG | NVDRDSRFSP | LYRQESSKMS | SEDLLKLVSD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YRRADRISKM | QSIPGSLDIA | VDNIPLEHPN | CVTSSFIPVK | PFNVSAQSEP | TVEVEEFIYD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| STKYCRPYRV | YKNQIYVYPK | HLKYDSQKCF | NKARNITVCI | EFKNSDDDGA | KPMKCIYGKP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GGPLFTSSAY | TAVLHHSQNP | DFSDEVKIEL | PTQLHGKHHL | LFSFYHITCD | INAKANAKKK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EALETSVGYA | WLPLMKHDQI | ASQEYNIPIA | TTLPPNYLSI | QDPTSAKHGG | SDIKWVDGGK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PLFKVSTFVV | STVNTQDPHV | NAFFRQCQKR | EKDMSQSPTS | SFVRACKNLL | NVDKIHSIMS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| FLPIILNQLF | KILVQNEEDE | ITATVTRVLA | DIVAKCHEEQ | LDHSVQSYIK | FVFKTKSYKE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| RTIHEELAKN | LSDLLKSNDS | TIVKHVLEHS | WFFFAIILKS | MAQHLIDTNK | IQLPRAQRFP |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ESYQSELDNL | VMGLCDHVIW | KCKEAPEETK | RANHSVARFL | KRCFTFMDRG | FVFKMVNNYI |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| SMFSSGEFKT | LCQYKFDFLQ | EVCQHEHFIP | LCLPIRSANI | PDPLTPSESI | RELHASDMPE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| YSVTNEFCRK | HFLIGILLRE | VGFALQEDQD | IRHLALAVLK | NLMAKHSFDD | RYREPRKQAQ |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| IASLYMPLYG | MLLDNMPRIY | LKDLYPFTVN | TSNQGSRDDL | STNGGFQTQT | SMKHATSVDT |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| SFSKDVLNSI | AAFSSIAIST | VNHADSRASL | ASLDSNPSTT | EKSSEKTDNC | EKIPRPLSLI |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| GSTLRFDKLD | QAETRSLLMC | FLHIMKTISD | ETLIAYWQRA | PSPEVSDFFS | ILDVCLQNFR |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| YLGKRNIIRK | IAAAFKFVQS | TQNNGTLKGS | NPSCQTSGLL | SQWMHTTSGH | EGHKQHRSQT |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| LPIIRGKNAL | SNPKLLQMLD | NSMNSNSNEI | DIVHHVDTEA | NIATEVCLTI | LDLLSLFTQV |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| HQRQLQQSDC | QNSLMKRVFD | TYMLFFQVNQ | SASALKHVFA | SLRLFVCKFP | SAFFQGPADL |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| CGSFCYEVLK | CCNHRSRLTQ | MEASALLYFF | MRKNFEFNKQ | KSIVRSHLQL | IKAVSQLIAD |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| AGIGGSRFQH | SLAITNNFAN | GDKQMKNSNF | PAEVKDLTKR | IRTVLMATAQ | MKEHEKDPEM |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| LVDLQYSLAN | SYASTPELRR | TWLESMAKIH | ARNGDLSEAA | MCYIHIAALI | AEYLKRKGYW |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| KMEKICTPPL | LPEDTQPCDS | NLLLTTPGGG | SMFSMGWPAF | LSITPNIKEE | GAMKEDSGMQ |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| DTPYNENILV | EQLYMCVEFL | WKSERYELIA | DVNKPIIAVF | EKQRDFKKLS | DLYYDIHRSY |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| LKVAEVVNSE | KRLFGRYYRV | AFYGQGFFEE | EEGKEYIYKE | PKLTGLSEIS | QRLLKLYADK |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| FGADNVKIIQ | DSNKVNPKDL | DPKYAYIQVT | YVTPFFEEKE | IEDRKTDFEM | HHNINRFVFE |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| TPFTLSGKKH | GGVAEQCKRR | TVLTTSHLFP | YVKKRIQVIS | QSSTELNPIE | VAIDEMSRKV |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| SELNQLCTTE | EVDMIRLQLK | LQGSVSVKVN | AGPMAYARAF | LEETNAKKYP | DNQVKLLKEI |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| FRQFADACGQ | ALDVNERLIK | EDQLEYQEEL | RSHYKDMLSE | LSAIMNEQIT | GRDDPAKCGV |
| 2170 | 2180 | ||||
| ERPYTTRVTS | KGTAAVPVVS | ISSSAEV |