Q8BIK4

PR
Gene name
Dock9
Protein name
Dedicator of cytokinesis protein 9
Names
Cdc42 guanine nucleotide exchange factor zizimin-1, Zizimin-1
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1227-1315 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BIK4

Entry ID Method Resolution Chain Position Source
AF-Q8BIK4-F1 Predicted AlphaFoldDB

No variants for Q8BIK4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8BIK4

No associated diseases with Q8BIK4

8 regional properties for Q8BIK4

Type Name Position InterPro Accession
domain Pleckstrin homology domain 185 - 294 IPR001849
domain Dedicator of cytokinesis C/D, N-terminal 57 - 167 IPR021816
domain C2 DOCK-type domain 646 - 836 IPR027007
domain DOCKER domain 1614 - 2055 IPR027357
domain Dedicator of cytokinesis D, C2 domain 648 - 837 IPR037809
domain DOCKER, Lobe A 1607 - 1755 IPR046769
domain DOCKER, Lobe B 1837 - 1912 IPR046770
domain DOCKER, Lobe C 1947 - 2048 IPR046773

Functions

Description
EC Number
Subcellular Localization
  • Endomembrane system
  • Associated with membranes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
small GTPase binding Binding to a small monomeric GTPase.

2 GO annotations of biological process

Name Definition
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BZ29 DOCK9 Dedicator of cytokinesis protein 9 Homo sapiens (Human) PR
Q8BZN6 Dock10 Dedicator of cytokinesis protein 10 Mus musculus (Mouse) PR
10 20 30 40 50 60
MGCTTSVILF KGIRTVFERN CAYMCKQPGE SNALEYTAYN WSKEDSELSI AFCLAKPKLI
70 80 90 100 110 120
EPLDYENVIV QKKTQILNDC LREMLLFPYD DFQTAILRRQ GRYLRSTVPA NAEEEAQSLF
130 140 150 160 170 180
VTECIKTYNS DWHLVTYKYE DYSGEFRQLP NKVPKLDKLP VHVYEVDEEA DKDEDAASLG
190 200 210 220 230 240
SQKGGITKHG WLYKGNMNSA ISVTMRSFKR RFFHLIQLGD GSYNLNFYKD EKISKEPKGS
250 260 270 280 290 300
IFLDSCMGVI QNNRVRRFAF ELKMQDKSSY LLAADSEAEM EEWVTVLNKI LQLNFEAAMQ
310 320 330 340 350 360
EKRNGDPHED DEQSKLEGSG SGLDSYLPEL AKSTREAEIK LKSESRVKLF YLDPDTQKLD
370 380 390 400 410 420
FSSAEPEVKP FEEKFGKRIL VKCNDLSFNL QCCVAENEEG PTTNVEPFFV TLSLFDIKYN
430 440 450 460 470 480
RKISADFHVD LNHFSVRQML APTSPALMNG GQSPPAFQDA LHTAMQYPKQ GIFSVTCPHP
490 500 510 520 530 540
DIFLVARIEK VLQGSITHCA EPYMRSSDSS KVAQKVLKNA KQACQRLGQY RMPFAWAART
550 560 570 580 590 600
LFKDTSGNLD KNARFSAIYR QDSNKLSNDD MLKLLADFRK PEKMAKLPVI LGNLDITIDS
610 620 630 640 650 660
VSCDFPNYLN SSYIPMRQFE TCSKSPITFE VEEFVPCIPK HTQPYTVYSN HLYVYPKYLK
670 680 690 700 710 720
YDSQKSFAKA RNIAICIEFK DSDEEDSQPL KCIYGRPGGP VFTRSALAAV LHHQQNPEFY
730 740 750 760 770 780
DEIKIELPAQ LHERHHLLFT FFHVSCDNST KGSTKKKDAV ETQVGFSWLP LLKDGRVLTS
790 800 810 820 830 840
EQHIPVSANL PSGYLGYQEL GMGRHYGPEV KWVEGGKPLL KISTHLVSTV YTQDQHLHNF
850 860 870 880 890 900
FQYCQKTESG AQASGSELVK YLKSLHAMEG HVMIAFLPTI LNQLFRVLTR ATQEEVAVNV
910 920 930 940 950 960
TRVIIHVVAQ CHEEGLESHL RSYVKFAYKA EPYVASEYKT VHEELTKSMT TILKPSADFL
970 980 990 1000 1010 1020
TSNKLLKYSW FFFDVLIKSM AQHLIENNKV KLLRNQRFPA SYHHAVETVV NMLMPHITQK
1030 1040 1050 1060 1070 1080
FRDNPEASKN ANHSLAVFIK RCFTFMDRGF VFKQINNYIS CFAPGDPKTL FEYKFEFLRV
1090 1100 1110 1120 1130 1140
VCNHEHYIPL NLPMPFGKGR IQRYQDLQLD YSLTDEFCRN HFLVGLLLRE VGTALQEFRE
1150 1160 1170 1180 1190 1200
VRVIAISMLK NLLIKHSFDD RYNSRSHQAR IATLYLPLFG LLIENVQRIN VRDVSPFPVN
1210 1220 1230 1240 1250 1260
PGSIVKDEAL AVPAGNPLMT PQKGNTLDHS LHKDLLGAIS GIASPYTAST PNINSVRNAD
1270 1280 1290 1300 1310 1320
SRGSLISTDS GNSLPDRNPE KSNSLDKQQQ SGMLGNSVVR CDKLDQSEIK SLLMCFLYVL
1330 1340 1350 1360 1370 1380
KSMSDDALFT YWNKASTAEL MDFFTISEVC LHQFQYMGKR YIARTGMMHA RLQQLGSLDN
1390 1400 1410 1420 1430 1440
SVTFNHSYGH SEADVVHQSL LEANIATEVC LTALDTLSLF TLAFKNQLLA DHGHNPLMKK
1450 1460 1470 1480 1490 1500
VFDVYLCFLQ KHQSEMALKN VFTALRSLIY KFPSAFYEGR ADMCASLCYE VLKCCNSKLS
1510 1520 1530 1540 1550 1560
SIRTEASQLL YFLMRNNFDY TGKKSFVRTH LQVIISVSQL IADVVGIGGT RFQQSLSIIN
1570 1580 1590 1600 1610 1620
NCANSDRIIK HTSFSSDVKD LTKRIRTVLM ATAQMKEHEN DPEMLVDLQY SLAKSYASTP
1630 1640 1650 1660 1670 1680
ELRKTWLDSM ARIHVKNGDL SEAAMCYVHV TALVAEYLTR KGMFRQGCTA FRVITPNIDE
1690 1700 1710 1720 1730 1740
EASMMEDVGM QDVHFNEDVL MELLEQCADG LWKAERYELI ADIYKLIIPI YEKRRDFERL
1750 1760 1770 1780 1790 1800
AHLYDTLHRA YSKVTEVMHS GRRLLGTYFR VAFFGQAAQY QFTDSETDVE GFFEDEDGKE
1810 1820 1830 1840 1850 1860
YIYKEPKLTP LSEISQRLLK LYSDKFGSEN VKMIQDSGKV NPKDLDSKFA YIQVTHVTPF
1870 1880 1890 1900 1910 1920
FDEKELQERR TEFERCHNIR RFMFEMPFTQ TGKRQGGVEE QCKRRTILTA IHCFPYVKKR
1930 1940 1950 1960 1970 1980
IPVMYQHHTD LNPIEVAIDE MSKKVAELRQ LCSSAEVDMI KLQLKLQGSV SVQVNAGPLA
1990 2000 2010 2020 2030 2040
YARAFLDDTN TKRYPDNKVK LLKEVFRQFV EACGQALAVN ERLIKEDQLE YQEEMKANYR
2050
EMAKELSDIM REQMG