Q8BWZ3
Gene name |
Naa25 (Mdm20) |
Protein name |
N-alpha-acetyltransferase 25, NatB auxiliary subunit |
Names |
Mitochondrial distribution and morphology protein 20, N-terminal acetyltransferase B complex subunit MDM20, NatB complex subunit MDM20, N-terminal acetyltransferase B complex subunit NAA25 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:231713 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BWZ3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BWZ3-F1 | Predicted | AlphaFoldDB |
41 variants for Q8BWZ3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3396165982 | 78 | D>G | No | EVA | |
| rs3388770425 | 145 | K>Q | No | EVA | |
| rs3388783129 | 148 | Y>H | No | EVA | |
| rs225654716 | 163 | A>T | No | EVA | |
| rs3395439782 | 254 | R>L | No | EVA | |
| rs3396076308 | 259 | N>K | No | EVA | |
| rs3388789298 | 261 | D>E | No | EVA | |
| rs3396039259 | 263 | W>* | No | EVA | |
| rs3396039230 | 272 | S>* | No | EVA | |
| rs3396272868 | 286 | E>G | No | EVA | |
| rs3388794250 | 294 | E>D | No | EVA | |
| rs32192100 | 316 | S>N | No | EVA | |
| rs3412972281 | 321 | R>* | No | EVA | |
| rs3388789274 | 388 | L>P | No | EVA | |
| rs3388780721 | 403 | A>V | No | EVA | |
| rs3388770441 | 421 | T>R | No | EVA | |
| rs3388773701 | 574 | Q>R | No | EVA | |
| rs3388788861 | 576 | D>H | No | EVA | |
| rs3388794338 | 577 | T>S | No | EVA | |
| rs3388787019 | 611 | Q>* | No | EVA | |
| rs3396103744 | 614 | T>S | No | EVA | |
| rs3388781124 | 619 | L>* | No | EVA | |
| rs3388783064 | 647 | V>D | No | EVA | |
| rs3388781116 | 688 | R>I | No | EVA | |
| rs216495815 | 723 | R>Q | No | EVA | |
| rs3388781147 | 728 | R>H | No | EVA | |
| rs3396159180 | 734 | L>Q | No | EVA | |
| rs3396096885 | 739 | E>D | No | EVA | |
| rs3388788831 | 759 | T>S | No | EVA | |
| rs3388785488 | 764 | F>L | No | EVA | |
| rs3388789697 | 772 | C>S | No | EVA | |
| rs243737829 | 783 | M>V | No | EVA | |
| rs32199754 | 806 | A>T | No | EVA | |
| rs3388794268 | 826 | V>L | No | EVA | |
| rs237061616 | 851 | I>V | No | EVA | |
| rs3388786981 | 865 | Y>H | No | EVA | |
| rs3388782721 | 867 | L>I | No | EVA | |
| rs3388770407 | 869 | I>T | No | EVA | |
| rs3388773658 | 933 | E>D | No | EVA | |
| rs258801529 | 935 | R>K | No | EVA | |
| rs32192474 | 939 | K>R | No | EVA |
No associated diseases with Q8BWZ3
No regional properties for Q8BWZ3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8BWZ3 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| NatB complex | A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| N-terminal peptidyl-methionine acetylation | The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine. |
2 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATRGHVQDP | NDRRLRPIYD | YLDNGNNKMA | IQQADKLLKK | HKDLHCAKVL | KAIGLQRTGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QEEAFTLAQE | VAALEPTDDN | SLQALTILYR | EMHRPELVTK | LYEAAVKKVP | NSEEYHSHLF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MAYARVGEYK | KMQQAGMALY | KIVPKNPYYF | WSVMSLIMQS | ISARDENLSK | TMFLPLAERM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VEKMVKEDKI | EAEAEVELYY | MILERLGKYQ | EALDVIRGKL | GEKLTSEIQS | RENKCMAMYK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KLSKWPECNA | LSRRLLLKNS | DDWQFYLTYF | DSVFRLIEEA | WTPPAEGEHS | LEGEVHCSAE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DAVKFIEDRI | TEASQSSRHV | RGPHLAKLEL | IRRLRSQGCN | DEYKLGDPEE | LMFQYFKKFG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DKPCCFTDLK | VFVDLLPAAQ | CTQFINQLLG | VVPLSTPTED | KLALPADIRG | LQQHLCVVQL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TRLLGLYHSM | DKSQKLDVVK | ELMLRYQHGL | EFGRSCLKTE | LQFSDYYCLL | AVHVLIDVWR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EAGEETAVWQ | ALTLLEEGLT | HSPSNAQFKL | LLVRIYCVLG | AFEPVVDLYS | SLDAKHIQHD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TIGYLLTRYA | ASLGQYAAAS | QSCNFALRFF | HSNQKDTSEY | IIQAYKYGAF | EKIPEFIAFR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NRLNNSLHFA | QVRTERMLLD | LLLEANISIS | LAESIKSMNL | RPEEDDVPWE | DLRDNRDLDV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FFSWDPKDRN | VSEEHKKLSL | EEETMWLRIR | SLTLRLISGL | PSLTHPVEPK | NSEKMSENGV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SSRIDILRLL | LQQLEVAVET | GKRFIEKEIQ | YPFLGPVPTR | MGRFFSSGCC | QCQVQSFHLV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SDMYELDTSG | LEGTVDIQER | IENSLASLLE | LLKGVFSTCK | GDLLEVTDGN | VKTQPAVLEN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LVFFVETISV | ILWVSSYCES | VLRPYKLNIQ | KKKKKKKETS | IIMPPIFTSF | QDYVTGLQTV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ISNAVDHIKG | LEAHLIALRL | EELTLEETSI | STEERKFSKT | VQGKVQSSYL | HSLLETGELL |
| 970 | |||||
| RKRLETTKKL | KI |