Q8BWT1

PR
Gene name
Acaa2
Protein name
3-ketoacyl-CoA thiolase, mitochondrial
Names
Acetyl-CoA acetyltransferase, Acetyl-CoA acyltransferase, Acyl-CoA hydrolase, mitochondrial, Beta-ketothiolase, Mitochondrial 3-oxoacyl-CoA thiolase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:52538
EC number
2.3.1.9: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

191-278 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BWT1

Entry ID Method Resolution Chain Position Source
AF-Q8BWT1-F1 Predicted AlphaFoldDB

11 variants for Q8BWT1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs252064637 10 V>I No EVA
rs3408822591 34 E>D No EVA
rs48938395 162 G>A No EVA
rs3407765879 166 E>K No EVA
rs3408856632 167 N>Y No EVA
rs243868780 237 S>P No EVA
rs3389506770 274 T>M No EVA
rs3389503046 281 G>D No EVA
rs49651325 290 T>A No EVA
rs3389419458 312 K>N No EVA
rs47497438 397 A>V No EVA

No associated diseases with Q8BWT1

5 regional properties for Q8BWT1

Type Name Position InterPro Accession
active_site Thiolase, active site 377 - 390 IPR020610
conserved_site Thiolase, conserved site 342 - 358 IPR020613
active_site Thiolase, acyl-enzyme intermediate active site 88 - 106 IPR020615
domain Thiolase, N-terminal 7 - 266 IPR020616
domain Thiolase, C-terminal 274 - 394 IPR020617

Functions

Description
EC Number 2.3.1.9 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

6 GO annotations of molecular function

Name Definition
acetyl-CoA C-acetyltransferase activity Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
acetyl-CoA C-acyltransferase activity Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
acetyl-CoA hydrolase activity Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+).
acyl-CoA hydrolase activity Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
myristoyl-CoA hydrolase activity Catalysis of the reaction: myristoyl-CoA + H2O <=> H+ + tetradecanoate + coenzyme A.
palmitoyl-CoA hydrolase activity Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.

5 GO annotations of biological process

Name Definition
acetyl-CoA metabolic process The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
cellular response to hypoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
negative regulation of mitochondrial membrane permeability involved in apoptotic process Any negative regulation of mitochondrial membrane permeability that is involved in apoptotic process.
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T0R7 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial Bos taurus (Bovine) PR
P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial Homo sapiens (Human) PR
10 20 30 40 50 60
MALLRGVFIV AAKRTPFGAY GGLLKDFSAT DLTEFAARAA LSAGKVPPET IDSVIVGNVM
70 80 90 100 110 120
QSSSDAAYLA RHVGLRVGVP TETGALTLNR LCGSGFQSIV SGCQEICSKD AEVVLCGGTE
130 140 150 160 170 180
SMSQSPYCVR NVRFGTKFGL DLKLEDTLWA GLTDQHVKLP MGMTAENLAA KYNISREDCD
190 200 210 220 230 240
RYALQSQQRW KAANEAGYFN EEMAPIEVKT KKGKQTMQVD EHARPQTTLE QLQKLPSVFK
250 260 270 280 290 300
KDGTVTAGNA SGVSDGAGAV IIASEDAVKK HNFTPLARVV GYFVSGCDPT IMGIGPVPAI
310 320 330 340 350 360
NGALKKAGLS LKDMDLIDVN EAFAPQFLSV QKALDLDPSK TNVSGGAIAL GHPLGGSGSR
370 380 390
ITAHLVHELR RRGGKYAVGS ACIGGGQGIA LIIQNTA