AiPD: Autoinhibited Protein Database

Gene name	ACAA2
Protein name	3-ketoacyl-CoA thiolase, mitochondrial
Names	Acetyl-CoA acetyltransferase, Acetyl-CoA acyltransferase, Acyl-CoA hydrolase, mitochondrial, Beta-ketothiolase, Mitochondrial 3-oxoacyl-CoA thiolase
Species	Bos taurus (Bovine)
KEGG Pathway	bta:522006
EC number	2.3.1.9: Transferring groups other than amino-acyl groups
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

176-281 (Predicted disordered autoinhibitory region) PR

176-281 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3T0R7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs441695456	13	K>E	No	EVA
rs459954412	15	T>N	No	EVA
rs473035015	15	T>P	No	EVA
rs439764267	16	P>S	No	EVA
rs209468994	20	Y>H	No	EVA
rs522531637	21	G>R	No	EVA
rs455071023	22	G>C	No	EVA
rs434879103	26	D>G	No	EVA
rs466194542	28	T>S	No	EVA
rs716926053	38	R>K	No	EVA
rs446647974	39	A>S	No	EVA
rs464320575	40	A>G	No	EVA
rs432959731	40	A>S	No	EVA
rs450695494	46	V>G	No	EVA
rs461587567	47	S>*	No	EVA
rs481664691	47	S>A	No	EVA
rs481664691	47	S>P	No	EVA
rs479582518	48	P>S	No	EVA
rs479582518	48	P>T	No	EVA
rs439818033	59	V>A	No	EVA
rs439818033	59	V>G	No	EVA
rs444608224	60	M>I	No	EVA
rs436087797	62	S>C	No	EVA
rs433138791	137	K>M	No	EVA
rs517849578	191	K>E	No	EVA
rs480776685	319	V>E	No	EVA
rs467049559	325	P>S	No	EVA
rs435625594	375	K>N	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	Acyl-CoA dehydrogenase, conserved site	215 - 227	IPR006089-1
conserved_site	Acyl-CoA dehydrogenase, conserved site	435 - 454	IPR006089-2
domain	Acyl-CoA oxidase/dehydrogenase, middle domain	213 - 315	IPR006091
domain	Acyl-CoA dehydrogenase/oxidase C-terminal	327 - 473	IPR009075
domain	Acyl-CoA dehydrogenase/oxidase, N-terminal	102 - 209	IPR013786

		Description
EC Number	2.3.1.9	Transferring groups other than amino-acyl groups
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
acetyl-CoA C-acetyltransferase activity	Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
acetyl-CoA C-acyltransferase activity	Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
acetyl-CoA hydrolase activity	Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+).
acyl-CoA hydrolase activity	Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
myristoyl-CoA hydrolase activity	Catalysis of the reaction: myristoyl-CoA + H2O <=> H+ + tetradecanoate + coenzyme A.
palmitoyl-CoA hydrolase activity	Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.

Name	Definition
fatty acid beta-oxidation	A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P42765	ACAA2	3-ketoacyl-CoA thiolase, mitochondrial	Homo sapiens (Human)	PR
Q8BWT1	Acaa2	3-ketoacyl-CoA thiolase, mitochondrial	Mus musculus (Mouse)	PR