Q8BTG7
PR
Gene name |
Ndrg4 (Kiaa1180, Ndr4) |
Protein name |
Protein NDRG4 |
Names |
N-myc downstream-regulated gene 4 protein, Protein Ndr4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:234593 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BTG7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BTG7-F1 | Predicted | AlphaFoldDB |
15 variants for Q8BTG7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs47713364 | 4 | C>* | No | EVA | |
| rs3399406205 | 4 | C>F | No | EVA | |
| rs3389000982 | 7 | G>V | No | EVA | |
| rs3388954154 | 10 | D>E | No | EVA | |
| rs3389004465 | 13 | T>M | No | EVA | |
| rs3388979736 | 22 | I>N | No | EVA | |
| rs3388954130 | 24 | G>D | No | EVA | |
| rs3388973391 | 28 | G>R | No | EVA | |
| rs3389004239 | 46 | C>* | No | EVA | |
| rs3388973375 | 48 | N>I | No | EVA | |
| rs3389004259 | 144 | K>* | No | EVA | |
| rs3389004457 | 182 | V>M | No | EVA | |
| rs3389000618 | 314 | R>L | No | EVA | |
| rs228725194 | 327 | S>N | No | EVA | |
| rs3389004513 | 339 | E>D | No | EVA |
No associated diseases with Q8BTG7
No regional properties for Q8BTG7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8BTG7 | |||
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cell projection membrane | The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| cell migration involved in heart development | The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. |
| negative regulation of platelet-derived growth factor receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. |
| negative regulation of smooth muscle cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. |
| negative regulation of smooth muscle cell proliferation | Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. |
| positive regulation of ERK1 and ERK2 cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| regulation of endocytic recycling | Any process that modulates the frequency, rate or extent of endocytic recycling. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| vesicle docking | The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. |
| visual learning | Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPECWDGEHD | IETPYGLLHV | VIRGSPKGNR | PAILTYHDVG | LNHKLCFNTF | FNFEDMQEIT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KHFVVCHVDA | PGQQVGASQF | PQGYQFPSME | QLAAMLPSVV | QHFGFKYVIG | IGVGAGAYVL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AKFALIFPDL | VEGLVLMNID | PNGKGWIDWA | ATKLSGLTST | LPDTVLSHLF | SQEELVNNTE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LVQSYRQQIS | NVVNQANLQL | FWNMYNSRRD | LDINRPGTVP | NAKTLRCPVM | LVVGDNAPAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EGVVECNSKL | DPTTTTFLKM | ADSGGLPQVT | QPGKLTEAFK | YFLQGMGYIA | HLKDRRLSGG |
| 310 | 320 | 330 | 340 | 350 | |
| AVPSASMTRL | ARSRTASLTS | ASSVDGSRPQ | PCAHSDSSEG | MGQVNHTMEV | SC |