Q8BSU7

SS
Gene name
Mob3a (Mobkl2a)
Protein name
MOB kinase activator 3A
Names
Mob1 homolog 2A , Mps one binder kinase activator-like 2A
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
mmu:208228
EC number
Protein Class

Descriptions

MOB1 protein is a key regulator of large tumor suppressor 1/2 (LATS1/2) kinases in the Hippo pathway. Full-length MOB1B is in the autoinhibited form, showing that the N-terminal extension blocks the LATS1 binding surface of MOB2B. Phosphorylation of Thr12 and Thr35 residues accelerates dissociation of the Switch helix from the LATS1-binding surface by the pull-the-string mechanism, thereby enabling LATS1 binding.

Autoinhibitory domains (AIDs)

1-41 (N-terminal extension including the Switch helix) SS

Target domain

45-208 (MH domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BSU7

Entry ID Method Resolution Chain Position Source
AF-Q8BSU7-F1 Predicted AlphaFoldDB

9 variants for Q8BSU7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389114884 15 T>I No EVA
rs3389114628 26 T>M No EVA
rs3389056552 67 D>E No EVA
rs264602029 72 I>V No EVA
rs3389112020 106 R>C No EVA
rs3389114883 112 A>V No EVA
rs3389087942 127 E>V No EVA
rs3389108174 196 E>K No EVA
rs3389112683 200 I>T No EVA

No associated diseases with Q8BSU7

5 regional properties for Q8BSU7

Type Name Position InterPro Accession
conserved_site Helix-turn-helix motif 124 - 149 IPR000047
domain Homeobox domain 93 - 157 IPR001356
conserved_site Homeobox, conserved site 128 - 151 IPR017970
domain Homeobox domain, metazoa 117 - 128 IPR020479-1
domain Homeobox domain, metazoa 132 - 151 IPR020479-2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Nucleus
  • Cytoplasm, cytosol
  • Cell membrane
  • Colocalizes with wts and cyclin E at the centrosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
protein kinase activator activity Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.

2 GO annotations of biological process

Name Definition
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43563 MOB2 CBK1 kinase activator protein MOB2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P40484 MOB1 DBF2 kinase activator protein MOB1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
Q86TA1 MOB3B MOB kinase activator 3B Homo sapiens (Human) SS
Q70IA8 MOB3C MOB kinase activator 3C Homo sapiens (Human) SS
Q96BX8 MOB3A MOB kinase activator 3A Homo sapiens (Human) SS
Q8BJG4 Mob3c MOB kinase activator 3C Mus musculus (Mouse) SS
Q8VE04 Mob3b MOB kinase activator 3B Mus musculus (Mouse) SS
Q8BPB0 Mob1b MOB kinase activator 1B Mus musculus (Mouse) EV
Q921Y0 Mob1a MOB kinase activator 1A Mus musculus (Mouse) SS
Q8GYX0 MOB1B MOB kinase activator-like 1B Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHI1 MOB1A MOB kinase activator-like 1A Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MDFLFGSRSS KTFKPKKNIP EGTHQYDLMK HAAATLGSGN LRNAVALPDG EDLNEWVAVN
70 80 90 100 110 120
TVDFFNQINM LYGTITEFCT EETCGIMSAG PKYEYHWADG LTVKKPIKCS APKYIDYLMT
130 140 150 160 170 180
WVQDQLDDET LFPSKIGVPF PKNFHSSAKT ILKRLFRVYA HIYHQHFTEV VTLGEEAHLN
190 200 210
TSFKHFIFFV QEFNLIERRE LAPLQELIDK LTAKDERQI