Q8BJG4
Gene name |
Mob3c (Mobkl2c) |
Protein name |
MOB kinase activator 3C |
Names |
Mob1 homolog 2C , Mps one binder kinase activator-like 2C |
Species |
Homo sapiens (Human) |
KEGG Pathway |
mmu:100465 |
EC number |
|
Protein Class |
KELCH DOMAIN-CONTAINING PROTEIN (PTHR46228) |
Descriptions
The ubiquitin-proteasome system (UPS) is a major pathway regulating eukaryotic protein levels. Selectivity for UPS protein substrates, containing terminal destabilizing motifs (degrons), is largely governed by E3 ligases, which modify proteins with ubiquitin (UB) to target them for degradation.
KLHDC2 is a substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.
Autoinhibition of KLHDC2 involves the self-assembly of its C-terminal Gly-Ser motif, which mimics a C-degron and engages the substrate-binding domain of another protomer in the homotetramer. This autoinhibited state prevents the binding of diGly substrates, ensuring that only true substrates that can displace the C-degron mimic can bind and activate the E3 ligase for ubiquitylation.
Autoinhibitory domains (AIDs)
Target domain |
44-207 (MH domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BJG4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BJG4-F1 | Predicted | AlphaFoldDB |
15 variants for Q8BJG4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388705069 | 33 | K>T | No | EVA | |
| rs3388702382 | 45 | R>L | No | EVA | |
| rs3388706736 | 54 | E>G | No | EVA | |
| rs3542834736 | 59 | W>* | No | EVA | |
| rs3388681129 | 81 | H>D | No | EVA | |
| rs3388695121 | 94 | P>S | No | EVA | |
| rs3388698105 | 109 | P>H | No | EVA | |
| rs3388706734 | 118 | M>K | No | EVA | |
| rs3388698081 | 130 | N>K | No | EVA | |
| rs3388708481 | 132 | E>V | No | EVA | |
| rs3388698153 | 145 | K>N | No | EVA | |
| rs3388701132 | 153 | K>R | No | EVA | |
| rs265015595 | 194 | Q>H | No | EVA | |
| rs3388704833 | 197 | S>R | No | EVA | |
| rs3388700128 | 203 | E>D | No | EVA |
No associated diseases with Q8BJG4
8 regional properties for Q8BJG4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | BRCT domain | 385 - 466 | IPR001357 |
| domain | Zinc finger, PARP-type | 10 - 92 | IPR001510-1 |
| domain | Zinc finger, PARP-type | 113 - 203 | IPR001510-2 |
| domain | Poly(ADP-ribose) polymerase, regulatory domain | 661 - 793 | IPR004102 |
| domain | WGR domain | 541 - 637 | IPR008893 |
| domain | Poly(ADP-ribose) polymerase, catalytic domain | 787 - 1013 | IPR012317 |
| domain | PARP1-like, PADR1 domain, zinc ribbon fold | 286 - 325 | IPR012982 |
| domain | PARP1-like, PADR1 domain, N-terminal helical subdomain | 225 - 284 | IPR049296 |
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR46228 | KELCH DOMAIN-CONTAINING PROTEIN |
| PANTHER Subfamily | PTHR46228:SF3 | KELCH DOMAIN-CONTAINING PROTEIN 2 |
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| protein kinase activator activity | Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43563 | MOB2 | CBK1 kinase activator protein MOB2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P40484 | MOB1 | DBF2 kinase activator protein MOB1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| Q86TA1 | MOB3B | MOB kinase activator 3B | Homo sapiens (Human) | SS |
| Q96BX8 | MOB3A | MOB kinase activator 3A | Homo sapiens (Human) | SS |
| Q70IA8 | MOB3C | MOB kinase activator 3C | Homo sapiens (Human) | SS |
| Q8BSU7 | Mob3a | MOB kinase activator 3A | Mus musculus (Mouse) | SS |
| Q8VE04 | Mob3b | MOB kinase activator 3B | Mus musculus (Mouse) | SS |
| Q8BPB0 | Mob1b | MOB kinase activator 1B | Mus musculus (Mouse) | EV |
| Q921Y0 | Mob1a | MOB kinase activator 1A | Mus musculus (Mouse) | SS |
| Q8GYX0 | MOB1B | MOB kinase activator-like 1B | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHI1 | MOB1A | MOB kinase activator-like 1A | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADGNEDLRA | DDLPGPAFES | YESMELACPA | ERSGHVAVSD | GRHMFVWGGY | KSNQVRGLYD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FYLPREELWI | YNMETGRWKK | INTEGDVPPS | MSGSCAVCVD | RVLYLFGGHH | SRGNTNKFYM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDSRSTDRVL | QWERIDCQGI | PPSSKDKLGV | WVYKNKLIFF | GGYGYLPEDK | VLGTFEFDET |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SFWNSSHPRG | WNDHVHILDT | ETFTWSQPIT | TGKAPSPRAA | HACATVGNRG | FVFGGRYRDA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RMNDLHYLNL | DTWEWNELIP | QGICPVGRSW | HSLTPVSSDH | LFLFGGFTTD | KQPLSDAWTY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CISKNEWIQF | NHPYTEKPRL | WHTACASDEG | EVIVFGGCAN | NLLVHHRAAH | SNEILIFSVQ |
| 370 | 380 | 390 | 400 | ||
| PKSLVRLSLE | AVICFKEMLA | NSWNCLPKHL | LHSVNQRFGS | NNTSGS |