Q8BND5
PR
Gene name |
Qsox1 (Qscn6, Sox) |
Protein name |
Sulfhydryl oxidase 1 |
Names |
mSOx, Quiescin Q6, Skin sulfhydryl oxidase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:104009 |
EC number |
1.8.3.2: With oxygen as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
7 structures for Q8BND5
50 variants for Q8BND5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388506429 | 29 | G>D | No | EVA | |
| rs3390841897 | 46 | T>A | No | EVA | |
| rs13466752 | 67 | E>K | No | EVA | |
| rs3388506415 | 70 | A>G | No | EVA | |
| rs864275903 | 80 | A>V | No | EVA | |
| rs3388503487 | 115 | E>D | No | EVA | |
| rs3388505645 | 134 | G>D | No | EVA | |
| rs864281869 | 137 | A>T | No | EVA | |
| rs3388510487 | 170 | P>S | No | EVA | |
| rs33699385 | 180 | D>N | No | EVA | |
| rs265379697 | 181 | G>E | No | EVA | |
| rs3388506499 | 189 | D>V | No | EVA | |
| rs3388510483 | 227 | D>E | No | EVA | |
| rs33700225 | 230 | N>S | No | EVA | |
| rs3388507738 | 238 | P>L | No | EVA | |
| rs3388505296 | 271 | G>E | No | EVA | |
| rs3388503464 | 291 | P>S | No | EVA | |
| rs3388505640 | 328 | Q>K | No | EVA | |
| rs3388509063 | 334 | K>* | No | EVA | |
| rs3388507729 | 341 | A>G | No | EVA | |
| rs3388510491 | 346 | G>W | No | EVA | |
| rs3388503470 | 355 | H>L | No | EVA | |
| rs3388509141 | 358 | N>Y | No | EVA | |
| rs3390756602 | 436 | Q>* | No | EVA | |
| rs3390674203 | 436 | Q>L | No | EVA | |
| rs3390752248 | 438 | V>D | No | EVA | |
| rs265158195 | 457 | D>N | No | EVA | |
| rs3388509080 | 464 | A>V | No | EVA | |
| rs3388505699 | 482 | T>N | No | EVA | |
| rs3388507744 | 485 | N>D | No | EVA | |
| rs13466753 | 500 | H>Y | No | EVA | |
| rs3388507748 | 503 | K>N | No | EVA | |
| rs3388505516 | 510 | E>D | No | EVA | |
| rs3388509193 | 510 | E>V | No | EVA | |
| rs3388509018 | 530 | A>G | No | EVA | |
| rs3388505288 | 534 | F>L | No | EVA | |
| rs244249716 | 556 | R>W | No | EVA | |
| rs227192605 | 559 | S>R | No | EVA | |
| rs33703172 | 580 | L>S | No | EVA | |
| rs33703173 | 598 | V>I | No | EVA | |
| rs235379606 | 600 | A>T | No | EVA | |
| rs3388505697 | 623 | G>R | No | EVA | |
| rs245214105 | 629 | R>H | No | EVA | |
| rs33703884 | 632 | D>E | No | EVA | |
| rs3388509082 | 639 | E>V | No | EVA | |
| rs3388508258 | 641 | A>G | No | EVA | |
| rs31403791 | 656 | F>L | No | EVA | |
| rs3390826106 | 724 | G>A | No | EVA | |
| rs3388509126 | 742 | H>Q | No | EVA | |
| rs3388505722 | 745 | Y>* | No | EVA |
No associated diseases with Q8BND5
4 regional properties for Q8BND5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Thioredoxin domain | 26 - 159 | IPR013766 |
| domain | ERV/ALR sulfhydryl oxidase domain | 399 - 507 | IPR017905 |
| domain | Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain | 298 - 399 | IPR040986 |
| domain | Sulfhydryl oxidase, Trx-like domain | 165 - 272 | IPR041269 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.8.3.2 | With oxygen as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of Golgi membrane | The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intercellular bridge | A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| FAD binding | Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
| flavin-linked sulfhydryl oxidase activity | Catalysis of the formation of disulfide bridges in proteins using FAD as the electron acceptor. |
| protein disulfide isomerase activity | Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| extracellular matrix assembly | The aggregation, arrangement and bonding together of the extracellular matrix. |
| negative regulation of macroautophagy | Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy. |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6ZRP7 | QSOX2 | Sulfhydryl oxidase 2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRRCGRLSGP | PSLLLLLLLL | SPLLFSGPGA | YAARLSVLYS | SSDPLTLLDA | DSVRPTVLGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSAWAVEFFA | SWCGHCIAFA | PTWKELANDV | KDWRPALNLA | VLDCAEETNS | AVCREFNIAG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FPTVRFFQAF | TKNGSGATLP | GAGANVQTLR | MRLIDALESH | RDTWPPACPP | LEPAKLNDID |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GFFTRNKADY | LALVFEREDS | YLGREVTLDL | SQYHAVAVRR | VLNTESDLVN | KFGVTDFPSC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YLLLRNGSVS | RVPVLVESRS | FYTSYLRGLP | GLTRDAPPTT | ATPVTADKIA | PTVWKFADRS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KIYMADLESA | LHYILRVEVG | KFSVLEGQRL | VALKKFVAVL | AKYFPGQPLV | QNFLHSINDW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LQKQQKKRIP | YSFFKAALDS | RKEDAVLTEK | VNWVGCQGSE | PHFRGFPCSL | WVLFHFLTVQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ANRYSEAHPQ | EPADGQEVLQ | AMRSYVQFFF | GCRDCADHFE | QMAAASMHQV | RSPSNAILWL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WTSHNRVNAR | LSGALSEDPH | FPKVQWPPRE | LCSACHNELN | GQVPLWDLGA | TLNFLKAHFS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PANIVIDSSA | SRHTGRRGSP | EATPELVMDT | LKLESRNSVL | GHEQAASAES | PGATALDVPA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EKPEASGPQE | LYTGLRMGGA | SPGQGPPERM | EDHQRDMQEN | APGQQHLSKR | DTEALFLPEV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NHLQGPLELR | RGGRSPKQLA | PILEEEPEAL | AIQGQGQWLQ | VLGGGISHLD | ISLCVGLYSV |
| 730 | 740 | ||||
| SFMGLLAMYT | YFRARLRTPK | GHASYPTA |