Q6ZRP7
PR
Gene name |
QSOX2 (QSCN6L1, SOXN) |
Protein name |
Sulfhydryl oxidase 2 |
Names |
Neuroblastoma-derived sulfhydryl oxidase, Quiescin Q6-like protein 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:169714 |
EC number |
1.8.3.2: With oxygen as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6ZRP7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6ZRP7-F1 | Predicted | AlphaFoldDB |
220 variants for Q6ZRP7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1554758498 CA375522732 |
2 | A>E | No |
ClinGen gnomAD |
|
|
rs1554758499 CA375522733 |
2 | A>S | No |
ClinGen gnomAD |
|
|
rs1554758498 CA375522730 |
2 | A>V | No |
ClinGen gnomAD |
|
|
rs1291302769 CA375522729 |
3 | A>T | No |
ClinGen TOPMed |
|
|
CA375522726 rs1554758494 |
3 | A>V | No |
ClinGen gnomAD |
|
|
rs1554758491 CA375522721 |
4 | A>S | No |
ClinGen gnomAD |
|
|
rs1554758491 CA375522723 |
4 | A>T | No |
ClinGen gnomAD |
|
|
CA375522718 rs1554758487 |
4 | A>V | No |
ClinGen gnomAD |
|
|
CA5331405 rs782533362 |
5 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375522716 rs1228778827 CA375522717 |
5 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1228778827 CA375522715 |
5 | G>W | No |
ClinGen TOPMed gnomAD |
|
|
CA375522709 rs1238300086 |
6 | A>E | No |
ClinGen TOPMed gnomAD |
|
|
rs1445469698 CA375522712 |
6 | A>S | No |
ClinGen TOPMed |
|
|
rs1238300086 CA375522707 |
6 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA375522701 rs1554758484 |
7 | A>V | No |
ClinGen gnomAD |
|
|
CA375522695 rs1554758482 |
8 | V>A | No |
ClinGen gnomAD |
|
|
rs1554758483 CA375522698 |
8 | V>L | No |
ClinGen gnomAD |
|
|
rs1406292777 CA375522692 |
9 | A>E | No |
ClinGen TOPMed gnomAD |
|
|
rs549282673 CA375522694 |
9 | A>S | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs549282673 CA201508715 |
9 | A>T | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA375522688 rs1157858474 |
10 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA375522686 rs1554758481 |
10 | R>H | No |
ClinGen gnomAD |
|
|
CA375522674 rs1554758479 |
12 | P>A | No |
ClinGen gnomAD |
|
|
CA375522671 rs1310618195 |
12 | P>R | No |
ClinGen TOPMed |
|
|
CA375522667 rs1554758478 |
13 | G>* | No |
ClinGen gnomAD |
|
|
rs1354723363 CA375522665 |
13 | G>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1354723363 CA375522666 |
13 | G>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1350328818 CA375522641 |
17 | G>E | No |
ClinGen TOPMed |
|
|
CA375522643 rs1279526463 CA375522644 |
17 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1588643986 CA375522628 |
19 | A>G | No |
ClinGen Ensembl |
|
|
CA375522632 rs1554758468 |
19 | A>T | No |
ClinGen TOPMed |
|
|
CA375522615 rs1256966007 |
21 | R>T | No |
ClinGen TOPMed |
|
|
rs1184551004 CA375522553 |
25 | S>L | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 25 | S>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA375522525 rs1469898524 |
27 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1231695893 CA375522530 |
27 | P>S | No |
ClinGen TOPMed |
|
|
rs1425429227 CA375522498 |
29 | R>Q | No |
ClinGen TOPMed |
|
|
CA375522474 rs1554758461 |
31 | A>T | No |
ClinGen gnomAD |
|
|
rs1588643951 CA375522463 |
31 | A>V | No |
ClinGen Ensembl |
|
|
rs1429860770 CA375522453 |
32 | R>Q | No |
ClinGen TOPMed |
|
|
rs1374359600 CA375522458 |
32 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA201508711 rs11550933 |
38 | V>G | No |
ClinGen Ensembl |
|
|
rs1554758459 CA375522304 |
43 | A>V | No |
ClinGen gnomAD |
|
|
rs1554758457 CA375522288 |
44 | A>V | No |
ClinGen gnomAD |
|
|
rs1554758452 CA375522271 |
45 | V>G | No |
ClinGen Ensembl |
|
|
rs868936549 CA375522260 |
46 | G>V | No |
ClinGen TOPMed |
|
|
rs1279918414 CA375522263 |
46 | G>W | No |
ClinGen TOPMed |
|
|
CA375522242 rs1271424417 |
47 | P>L | No |
ClinGen TOPMed |
|
|
rs1197647143 CA375522251 |
47 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1222759250 CA375522236 |
48 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
CA375522240 rs1437831077 |
48 | G>S | No |
ClinGen TOPMed |
|
|
rs1455279722 CA375522216 |
49 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA375522213 rs1191314187 |
50 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs782455625 CA5331403 |
53 | A>G | No |
ClinGen ExAC gnomAD |
|
|
CA5331402 rs782455625 |
53 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1554758443 CA375522156 |
54 | R>W | No |
ClinGen gnomAD |
|
|
rs1169146595 CA375522144 |
55 | L>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1554758440 CA375522132 |
56 | Y>D | No |
ClinGen gnomAD |
|
|
rs782095703 CA5331399 |
57 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375522115 rs782095703 |
57 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5331398 rs781948371 |
58 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs530894426 CA5331397 |
60 | E>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA375522062 rs1554758434 |
61 | D>G | No |
ClinGen gnomAD |
|
|
rs1438469898 CA375522067 |
61 | D>N | No |
ClinGen TOPMed |
|
|
CA375522038 rs1554758431 |
64 | W>C | No |
ClinGen gnomAD |
|
|
COSM753190 CA375522023 rs1554758429 |
67 | D>A | lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs782397498 CA5331393 |
69 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA5331394 rs570092339 |
69 | G>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5331395 rs570092339 |
69 | G>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs782248458 CA5331392 |
70 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA375522004 rs781976600 |
70 | S>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1554758425 CA375522002 |
70 | S>R | No |
ClinGen gnomAD |
|
|
rs781976600 CA5331391 |
70 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5331390 rs782343857 |
71 | V>E | No |
ClinGen ExAC gnomAD |
|
|
rs1554758424 CA375522000 |
71 | V>M | No |
ClinGen gnomAD |
|
|
CA375521994 rs1229702680 |
72 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1268553798 CA375521990 |
73 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA375521988 rs1268553798 |
73 | G>W | No |
ClinGen TOPMed gnomAD |
|
|
rs782573364 CA5331388 |
74 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782283125 CA5331386 |
76 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1229432614 CA375521967 |
77 | N>D | No |
ClinGen TOPMed gnomAD |
|
|
CA5331385 rs782649736 |
77 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375521954 rs370719089 |
78 | S>R | No |
ClinGen ESP ExAC gnomAD |
|
|
rs781834700 CA5331383 |
81 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs868967852 CA375521928 |
82 | W>* | No |
ClinGen Ensembl |
|
|
CA375521931 rs868981371 |
82 | W>L | No |
ClinGen Ensembl |
|
|
CA375521919 rs1251918445 |
84 | V>L | No |
ClinGen TOPMed |
|
|
CA375521921 rs1251918445 |
84 | V>M | No |
ClinGen TOPMed |
|
|
CA375521914 rs1194678172 |
85 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
CA375521911 rs1554758413 |
85 | Q>R | No |
ClinGen gnomAD |
|
|
rs782444030 CA375521901 |
86 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375521896 rs1474814297 |
87 | Y>C | No |
ClinGen TOPMed |
|
|
rs776361299 CA201508567 |
87 | Y>H | No |
ClinGen Ensembl |
|
|
rs781786081 CA5331380 |
88 | S>L | No |
ClinGen ExAC gnomAD |
|
|
rs782805570 CA5331379 |
89 | S>L | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 89 | S>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA375521874 rs1419957062 |
90 | W>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1165501289 CA375521878 |
90 | W>S | No |
ClinGen TOPMed |
|
|
rs1564300528 CA375521853 |
93 | H>Q | No |
ClinGen Ensembl |
|
|
CA5331376 rs782753633 |
97 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs1554758406 CA375521820 |
98 | A>G | No |
ClinGen gnomAD |
|
|
rs782087184 CA5331375 |
98 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782294341 CA5331372 |
100 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs782314775 CA5331373 |
100 | T>P | No |
ClinGen ExAC gnomAD |
|
|
rs1325887892 CA375521797 |
102 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
COSM1724246 CA201508503 rs201912074 |
102 | R>W | NS [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
CA375521793 rs1554758401 |
103 | A>S | No |
ClinGen gnomAD |
|
|
CA5331371 rs782021344 |
103 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA201508480 rs1034909104 |
104 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
rs782394109 CA375521783 |
105 | A>D | No |
ClinGen ExAC gnomAD |
|
|
CA5331370 rs782394109 |
105 | A>G | No |
ClinGen ExAC gnomAD |
|
|
CA375521771 rs1233052664 |
107 | D>G | No |
ClinGen TOPMed |
|
|
CA375521760 rs782247963 |
109 | R>* | No |
ClinGen ExAC gnomAD |
|
|
rs782614999 CA5331368 |
109 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA375521756 rs1350913848 |
110 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
CA375521757 rs1350913848 |
110 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
CA201561104 rs537708113 |
112 | A>T | No |
ClinGen 1000Genomes |
|
| TCGA novel | 113 | S>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs745954157 CA5331342 |
115 | I>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375527460 rs1468819696 |
115 | I>T | No |
ClinGen gnomAD |
|
|
CA5331343 rs769809900 |
115 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA5331341 rs776714660 |
116 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs144677667 CA5331340 |
116 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs747314448 CA5331339 |
117 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1479933218 CA375527448 |
118 | A>P | No |
ClinGen TOPMed |
|
|
CA5331338 COSM487220 rs376604129 |
118 | A>V | kidney Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed |
|
rs1443786097 CA375527426 |
121 | D>E | No |
ClinGen gnomAD |
|
|
CA375527433 rs1226139758 |
121 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs953223468 CA201561081 |
123 | M>K | No |
ClinGen Ensembl |
|
|
rs748616900 CA375527417 |
123 | M>L | No |
ClinGen ExAC gnomAD |
|
|
rs748616900 CA5331336 |
123 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA5331335 VAR_027435 rs12380852 |
126 | K>E | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1459362760 CA375527389 |
126 | K>N | No |
ClinGen gnomAD |
|
|
CA5331334 rs182367188 |
128 | Q>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
COSM1461042 CA375527366 rs1474987923 |
130 | V>M | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs928242771 CA201561065 |
132 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
CA375527350 rs1430632467 |
132 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
CA375527342 rs1588637615 |
133 | D>A | No |
ClinGen Ensembl |
|
|
rs772302726 CA201561061 |
134 | Y>C | No |
ClinGen Ensembl |
|
|
rs1588637608 CA375527328 |
135 | D>A | No |
ClinGen Ensembl |
|
|
rs750150917 CA5331330 |
135 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs897755421 CA201561047 |
137 | H>D | No |
ClinGen Ensembl |
|
|
rs767299034 CA5331329 |
137 | H>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375527306 rs1035949154 |
138 | F>C | No |
ClinGen TOPMed |
|
|
rs1035949154 CA201561037 |
138 | F>S | No |
ClinGen TOPMed |
|
|
CA201561030 rs1023818372 |
142 | F>L | No |
ClinGen TOPMed |
|
| TCGA novel | 143 | R>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA201561027 rs146612471 |
143 | R>Q | No |
ClinGen ESP |
|
| TCGA novel | 143 | R>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5331305 rs762918603 |
145 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA5331303 rs766432618 |
147 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1249974483 CA375527217 |
150 | K>E | No |
ClinGen gnomAD |
|
|
rs1190300758 CA375527210 |
151 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA201560158 rs956730597 |
152 | F>L | No |
ClinGen gnomAD |
|
|
CA201560155 rs967541020 |
153 | T>K | No |
ClinGen TOPMed gnomAD |
|
|
CA375527185 rs1208373724 |
154 | T>I | No |
ClinGen gnomAD |
|
|
CA375527186 rs1208373724 |
154 | T>S | No |
ClinGen gnomAD |
|
|
rs773415345 CA5331301 |
156 | E>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA375527170 rs1222770886 |
157 | N>D | No |
ClinGen gnomAD |
|
| TCGA novel | 158 | F>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs758145655 | 160 | G>E | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs918490315 | 163 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs369929602 | 171 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 186 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 196 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs376505854 | 201 | S>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs376098174 | 211 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 235 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs377757090 | 237 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1282168889 | 259 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs772753193 | 267 | G>E | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 267 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs201972372 | 268 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs767414712 | 274 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs746838402 CA5331087 |
275 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5331086 rs746838402 |
275 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770259568 CA201557231 |
277 | P>L | No |
ClinGen Ensembl |
|
|
rs1264886612 CA375526344 |
277 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs766516788 CA5331082 COSM1106745 |
279 | R>Q | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs752708799 CA5331083 |
279 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1385954800 CA375526333 |
280 | A>T | No |
ClinGen TOPMed |
|
|
rs139939482 CA5331081 |
280 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs546723008 CA5331079 |
283 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 295 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1415493786 | 300 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs747175246 | 324 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 332 | H>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1166290992 | 342 | H>Y | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs369920025 | 347 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 360 | L>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 362 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs770075933 | 367 | R>W | Variant assessed as Somatic; 4.659e-05 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs781617567 | 368 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1437393716 | 393 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs200166292 | 394 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 403 | R>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs368735255 | 403 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 429 | P>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs757462508 | 513 | G>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs373189547 | 514 | R>L | Variant assessed as Somatic; 4.631e-05 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 546 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs780960010 | 554 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs368303324 | 570 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs768957094 | 573 | A>T | Variant assessed as Somatic; 0.0001386 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1025997751 | 575 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1315193559 | 586 | R>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 587 | G>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 598 | E>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1408832570 | 610 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 617 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1554755718 | 628 | S>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 631 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs771629774 | 631 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 640 | G>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs754218036 | 647 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 648 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs142355207 | 649 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 649 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 661 | M>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 685 | R>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
No associated diseases with Q6ZRP7
4 regional properties for Q6ZRP7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Thioredoxin domain | 34 - 178 | IPR013766 |
| domain | ERV/ALR sulfhydryl oxidase domain | 421 - 531 | IPR017905 |
| domain | Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain | 318 - 421 | IPR040986 |
| domain | Sulfhydryl oxidase, Trx-like domain | 185 - 292 | IPR041269 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.8.3.2 | With oxygen as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of Golgi membrane | The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| flavin-linked sulfhydryl oxidase activity | Catalysis of the formation of disulfide bridges in proteins using FAD as the electron acceptor. |
| protein disulfide isomerase activity | Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8BND5 | Qsox1 | Sulfhydryl oxidase 1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAAGAAVAR | SPGIGAGPAL | RARRSPPPRA | ARLPRLLVLL | AAAAVGPGAG | GAARLYRAGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DAVWVLDSGS | VRGATANSSA | AWLVQFYSSW | CGHCIGYAPT | WRALAGDVRD | WASAIRVAAL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DCMEEKNQAV | CHDYDIHFYP | TFRYFKAFTK | EFTTGENFKG | PDRELRTVRQ | TMIDFLQNHT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EGSRPPACPR | LDPIQPSDVL | SLLDNRGSHY | VAIVFESNSS | YLGREVILDL | IPYESIVVTR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ALDGDKAFLE | KLGVSSVPSC | YLIYPNGSHG | LINVVKPLRA | FFSSYLKSLP | DVRKKSLPLP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EKPHKEENSE | IVVWREFDKS | KLYTVDLESG | LHYLLRVELA | AHKSLAGAEL | KTLKDFVTVL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AKLFPGRPPV | KKLLEMLQEW | LASLPLDRIP | YNAVLDLVNN | KMRISGIFLT | NHIKWVGCQG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SRSELRGYPC | SLWKLFHTLT | VEASTHPDAL | VGTGFEDDPQ | AVLQTMRRYV | HTFFGCKECG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EHFEEMAKES | MDSVKTPDQA | ILWLWKKHNM | VNGRLAGHLS | EDPRFPKLQW | PTPDLCPACH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EEIKGLASWD | EGHVLTFLKQ | HYGRDNLLDT | YSADQGDSSE | GGTLARGEEE | EKRLTPPEVS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HGDRDTQSVR | PPGALGPRPA | LPESLHHSLD | GKLQSLDGPG | AHKEVGGAAP | FLGVDFSSLD |
| 670 | 680 | 690 | |||
| MSLCVVLYVA | SSLFLMVMYF | FFRVRSRRWK | VKHHHPAV |