Q8BKC5
PR
Gene name |
Ipo5 (Kpnb3, Ranbp5) |
Protein name |
Importin-5 |
Names |
Imp5, Importin subunit beta-3, Karyopherin beta-3, Ran-binding protein 5, RanBP5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70572 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BKC5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BKC5-F1 | Predicted | AlphaFoldDB |
52 variants for Q8BKC5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389349985 | 43 | T>K | No | EVA | |
| rs3389329656 | 168 | H>Y | No | EVA | |
| rs3389354693 | 172 | V>L | No | EVA | |
| rs3389354689 | 182 | Q>* | No | EVA | |
| rs3389350160 | 184 | Q>* | No | EVA | |
| rs3389329665 | 195 | R>G | No | EVA | |
| rs3389350019 | 215 | A>V | No | EVA | |
| rs225738999 | 299 | S>N | No | EVA | |
| rs238776212 | 300 | L>I | No | EVA | |
| rs3389350200 | 329 | D>G | No | EVA | |
| rs3389329618 | 334 | S>C | No | EVA | |
| rs3389350232 | 350 | L>V | No | EVA | |
| rs3406047027 | 409 | Q>E | No | EVA | |
| rs3389318061 | 427 | A>P | No | EVA | |
| rs3389337941 | 447 | L>P | No | EVA | |
| rs3389329629 | 506 | K>M | No | EVA | |
| rs3389318075 | 577 | A>V | No | EVA | |
| rs3389318052 | 607 | A>T | No | EVA | |
| rs3389345661 | 616 | G>V | No | EVA | |
| rs3389337975 | 652 | S>I | No | EVA | |
| rs3389363506 | 654 | D>N | No | EVA | |
| rs3389342906 | 659 | F>S | No | EVA | |
| rs3389350206 | 668 | F>L | No | EVA | |
| rs3389350203 | 723 | A>S | No | EVA | |
| rs3389329680 | 730 | L>M | No | EVA | |
| rs3389363487 | 739 | P>S | No | EVA | |
| rs3405891009 | 746 | W>S | No | EVA | |
| rs3404912986 | 748 | F>I | No | EVA | |
| rs3405597577 | 748 | F>L | No | EVA | |
| rs3405688231 | 749 | M>K | No | EVA | |
| rs3405752750 | 751 | D>H | No | EVA | |
| rs3389350208 | 756 | A>G | No | EVA | |
| rs3389342844 | 760 | E>V | No | EVA | |
| rs3389363546 | 791 | E>K | No | EVA | |
| rs3389350231 | 863 | Q>* | No | EVA | |
| rs232433326 | 892 | V>I | No | EVA | |
| rs3389350224 | 897 | P>S | No | EVA | |
| rs3389337991 | 902 | Y>F | No | EVA | |
| rs3389359535 | 904 | E>K | No | EVA | |
| rs3389347595 | 908 | S>G | No | EVA | |
| rs3405752777 | 924 | A>T | No | EVA | |
| rs3389363518 | 924 | A>V | No | EVA | |
| rs3404983960 | 926 | A>P | No | EVA | |
| rs3406046972 | 929 | L>R | No | EVA | |
| rs3405688221 | 933 | A>P | No | EVA | |
| rs3404254709 | 935 | F>L | No | EVA | |
| rs3405597567 | 974 | S>L | No | EVA | |
| rs3404983945 | 978 | K>N | No | EVA | |
| rs3389359536 | 1037 | K>I | No | EVA | |
| rs3389300904 | 1080 | A>V | No | EVA | |
| rs3389342877 | 1088 | A>T | No | EVA | |
| rs3389311670 | 1090 | I>T | No | EVA |
No associated diseases with Q8BKC5
6 regional properties for Q8BKC5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | HEAT repeat | 907 - 935 | IPR000357 |
| domain | Importin-beta, N-terminal domain | 45 - 99 | IPR001494 |
| domain | TOG domain | 348 - 594 | IPR034085 |
| repeat | Importin repeat | 1005 - 1052 | IPR040928 |
| repeat | Importin repeat 6 | 765 - 872 | IPR041389 |
| repeat | Importin repeat 4 | 269 - 357 | IPR041653 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| nuclear import signal receptor activity | Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein. |
| nuclear localization sequence binding | Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. |
| small GTPase binding | Binding to a small monomeric GTPase. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to amino acid stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. |
| NLS-bearing protein import into nucleus | The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope. |
| positive regulation of protein import into nucleus | Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus. |
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
| ribosomal protein import into nucleus | The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane. At least some ribosomal proteins, including rpl12, uses the importin 11 pathway as a major route into the nucleus. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAAAAEQQQ | FYLLLGNLLS | PDNVVRKQAE | ETYENIPGRS | KITFLLQAIR | NTTAAEEARQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MAAVLLRRLL | SSAFDEVYPA | LPSDVQTAIK | SELLMIIQME | TQSSMRKKIC | DIAAELARNL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IDEDGNNQWP | EGLKFLFDSV | SSQNMGLREA | ALHIFWNFPG | IFGNQQQHYL | DVIKRMLVQC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MQDQEHPSIR | TLSARATAAF | ILANEHNVAL | FKHFADLLPG | FLQAVNDSCY | QNDDSVLKSL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VEIADTVPKY | LRPHLEATLQ | LSLKLCGDTN | LNNMQRQLAL | EVIVTLSETA | AAMLRKHTSL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IAQTIPQMLA | MMVDLEEDED | WANADELEDD | DFDSNAVAGE | SALDRMACGL | GGKLVLPMIK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EHIMQMLQNP | DWKYRHAGLM | ALSAIGEGCH | QQMEGILNEI | VNFVLLFLQD | PHPRVRYAAC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NAVGQMATDF | APGFQKKFHE | KVIAALLQTM | EDQGNQRVQA | HAAAALINFT | EDCPKSLLIP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YLDNLVKHLH | SIMVLKLQEL | IQKGTKLVLE | QVVTSIASVA | DTAEEKFVPY | YDLFMPSLKH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IVENAVQKEL | RLLRGKTIEC | ISLIGLAVGK | EKFMQDASDV | MQLLLKTQTD | FNDMEDDDPQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ISYMISAWAR | MCKILGKEFQ | QYLPVVMGPL | MKTASIKPEV | ALLDTQDMEN | MSDDDGWEFV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NLGDQQSFGI | KTAGLEEKST | ACQMLVCYAK | ELKEGFVEYT | EQVVKLMVPL | LKFYFHDGVR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VAAAESMPLL | LECARVRGPE | YLTQMWHFMC | DALIKAIGTE | PDSDVLSEIM | HSFAKCIEVM |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GDGCLNNEHF | EELGGILKAK | LEEHFKNQEL | RQVKRQDEDY | DEQVEESLQD | EDDNDVYILT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KVSDILHSIF | SSYKEKVLPW | FEQLLPLIVN | LICPQRPWPD | RQWGLCIFDD | IVEHCSPASF |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KYAEYFISPM | LQYVCDNSPE | VRQAAAYGLG | VMAQFGGDNY | RPFCTDALPL | LVRVIQAPEA |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KTKENVNATE | NCISAVGKIM | KFKPDCVNVE | EVLPHWLSWL | PLHEDKEEAV | QTFSYLCDLI |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ESNHPIVLGP | NNTNLPKIFS | IIAEGEMHEA | IKHEDPCAKR | LANVVRQVQT | SGGLWTECIA |
| 1090 | |||||
| QLSPEQQAAI | QELLNSA |