Q8BIV3

PR
Gene name
Ranbp6
Protein name
Ran-binding protein 6
Names
RanBP6
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:240614
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

790-861 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BIV3

Entry ID Method Resolution Chain Position Source
AF-Q8BIV3-F1 Predicted AlphaFoldDB

21 variants for Q8BIV3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3409054931 161 H>P No EVA
rs3389545692 170 F>V No EVA
rs3389549836 189 I>F No EVA
rs3389490106 231 Q>R No EVA
rs3408450390 238 Y>* No EVA
rs3389545733 250 E>A No EVA
rs3389442450 339 D>Y No EVA
rs3408766747 392 A>T No EVA
rs252926196 483 K>R No EVA
rs3409343352 516 A>V No EVA
rs3408037378 517 L>* No EVA
rs3408977400 584 D>A No EVA
rs3408037360 584 D>E No EVA
rs3412849134 677 G>C No EVA
rs3389482260 865 I>F No EVA
rs3389533184 925 N>S No EVA
rs3389534276 945 G>R No EVA
rs3389529947 964 K>R No EVA
rs3389545679 1015 E>K No EVA
rs233264122 1099 H>Q No EVA
rs3409343354 1106 A>S No EVA

No associated diseases with Q8BIV3

4 regional properties for Q8BIV3

Type Name Position InterPro Accession
repeat HEAT repeat 917 - 943 IPR000357
repeat Importin repeat 1013 - 1059 IPR040928
repeat Importin repeat 6 773 - 880 IPR041389
repeat Importin repeat 4 279 - 365 IPR041653

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
nuclear import signal receptor activity Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
nuclear localization sequence binding Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.

1 GO annotations of biological process

Name Definition
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O00410 IPO5 Importin-5 Homo sapiens (Human) PR
O60518 RANBP6 Ran-binding protein 6 Homo sapiens (Human) PR
Q8BKC5 Ipo5 Importin-5 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAAAGSAGLP ATVSEKQEFY QLLKNLINPS CMVRRQAEEV YENIPGLCKT TFLLDAVRNR
70 80 90 100 110 120
RAGYEVRQMA AALLRRLLSS GFEEVYPNLP PEVQRDVKIE LILAVKLETH ASMRKKLCDI
130 140 150 160 170 180
FAVLARNLID ESGTNHWPEG LKFLIDSIHS KNVVLWEVAL HVFWHFPGIF GNQDRHDLDI
190 200 210 220 230 240
IKRLLDQCIQ DQEHPAIRTL SARAAATFVL ANENNIALFK DFADLLPGIL QAVNDSCYQD
250 260 270 280 290 300
DDSVLESLVE IADTVPKYLG PYLEDTLQLS LKLCGDSRLS NLQRQLALEV IVTLSETATP
310 320 330 340 350 360
MLKKHTNIIA QAVPHILAMM VDLQDDDDWV NADEMEEDDF DSNAVAAESA LDRLACGLGG
370 380 390 400 410 420
KVVLPMTKEH IMQMLQSPDW KCRHAGLMAL SAIGEGCHQQ MEPILDETVN SVLLFLQDPH
430 440 450 460 470 480
PRVRAAACTT LGQMATDFAP SFQKKFHEIV ITALLRTMEN QGNQRVQSHA ASALVIFIED
490 500 510 520 530 540
CPKSLLILYL ENMVKSLHSI LVIKLQELIR NGTKLALEQL VTTIASVADA IEESFIPYYD
550 560 570 580 590 600
IFMPSLKHVV ELAVQKELKL LRGKTIECIS HVGLAVGKEK FMQDASNVMQ LLLKTQSDLN
610 620 630 640 650 660
NMEDDDPQTS YMVSAWARMC KILGKDFEQY LPLVIEPLIK TASAKPDVAL LDTQDVENMS
670 680 690 700 710 720
DDDGWQFVNL GDQQSFGIKT SGLEAKATAC QMLVYYAKEL REGFVEYTEQ VVKMMVPLLK
730 740 750 760 770 780
FYFHDNVRVA AAEAMPFLLE CARIRGSEYL SQMWQFICDP LIKAIGTEPD TDVLSEIMNS
790 800 810 820 830 840
FAKSIEVMGD GCLNDEHLEE LGGILKAKLE GHFKNQELRQ VKRQEENYDQ QVEMSLQDED
850 860 870 880 890 900
ECDVYILTKV SDILHSLFST YKEKILPWFE QLLPLIVNLI CSSRPWPDRQ WGLCIFDDII
910 920 930 940 950 960
EHCSPTSFKY VEYFRWPMLL NMRDNNPEVR QAAAYGLGVM AQFGGDDYRS LCSEAVPLLV
970 980 990 1000 1010 1020
KVIKCANSKT KKNVIATENC ISAIGKILKF KPNCVNVDEV LPHWLSWLPL HEDKEEAIQT
1030 1040 1050 1060 1070 1080
LNFLCDLIES NHPVVIGPNN SNLPKIISII AEGKINETIS HEDPCAKRLA NVVRQIQTSE
1090 1100
ELWLECTSQL DDEQQEALHE LLSFA