AiPD: Autoinhibited Protein Database

Gene name	Ubap1
Protein name	Ubiquitin-associated protein 1
Names	UBAP-1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:67123
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

44-184 (Predicted disordered autoinhibitory region) PR

44-184 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BH48-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388671655	6	L>F	No	EVA
rs3388675574	51	E>V	No	EVA
rs3388657140	58	L>*	No	EVA
rs3413009909	90	V>A	No	EVA
rs3388676876	95	G>D	No	EVA
rs3388675493	120	I>T	No	EVA
rs228340038	128	N>S	No	EVA
rs3388657156	163	E>G	No	EVA
rs3388677638	201	A>T	No	EVA
rs248382387	207	A>T	No	EVA
rs3388657118	208	V>E	No	EVA
rs3388678045	214	V>F	No	EVA
rs3394161403	244	E>D	No	EVA
rs3394006243	244	E>G	No	EVA
rs3388673506	259	T>A	No	EVA
rs3388664621	266	L>I	No	EVA
rs3388671618	283	L>I	No	EVA
rs3388677684	290	T>R	No	EVA
rs3388664584	311	S>N	No	EVA
rs3388675533	336	T>I	No	EVA
rs28303069	375	M>T	No	EVA
rs28303068	414	R>K	No	EVA
rs251328028	418	E>Q	No	EVA
rs211886777	418	E>V	No	EVA
rs3394168356	420	I>T	No	EVA
rs3388681536	486	N>Y	No	EVA

Type	Name	Position	InterPro Accession
domain	Ubiquitin-associated domain	389 - 430	IPR015940-1
domain	Ubiquitin-associated domain	451 - 498	IPR015940-2
domain	UMA domain	17 - 63	IPR023340

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Endosome	Predominantly cytosolic Recruited to endosomes as part of the ESCRT-I complex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
ESCRT I complex	An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
ubiquitin binding	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

Name	Definition
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9NZ09	UBAP1	Ubiquitin-associated protein 1	Homo sapiens (Human)	PR
Q5XIS7	Ubap1	Ubiquitin-associated protein 1	Rattus norvegicus (Rat)	PR