Q5XIS7

PR
Gene name
Ubap1
Protein name
Ubiquitin-associated protein 1
Names
UBAP-1
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:362502
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

47-131 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5XIS7

Entry ID Method Resolution Chain Position Source
AF-Q5XIS7-F1 Predicted AlphaFoldDB

3 variants for Q5XIS7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs197425963 444 E>D No EVA
rs198640346 445 E>A No EVA
rs106592886 477 I>T No EVA

No associated diseases with Q5XIS7

3 regional properties for Q5XIS7

Type Name Position InterPro Accession
domain Ubiquitin-associated domain 389 - 430 IPR015940-1
domain Ubiquitin-associated domain 451 - 498 IPR015940-2
domain UMA domain 17 - 63 IPR023340

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Endosome
  • Predominantly cytosolic
  • Recruited to endosomes as part of the ESCRT-I complex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
ESCRT I complex An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

2 GO annotations of biological process

Name Definition
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NZ09 UBAP1 Ubiquitin-associated protein 1 Homo sapiens (Human) PR
Q8BH48 Ubap1 Ubiquitin-associated protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MASKKLGTDF HGTFSYLDDV PFKIGDKFKT PAKVGLPIGF SLPDCLQVVR EMQYDFSLEK
70 80 90 100 110 120
KAIEWAEDIR LIQEAQQEAE RKSEEAEAKV NSKSGPEGDS KVSFSKTHSP ATMPPPINPI
130 140 150 160 170 180
LASLQHNNIL TPTRVSSSAT KQKVLSPPHT KADFNPADFE CEEDPFDNLE LKTIDEKEEL
190 200 210 220 230 240
RNILVGTTGP IMAQLLDSNT PRGNSGSVLQ DEEVLASLEQ ATLDFKPLHK PNGFITLPQL
250 260 270 280 290 300
GNCEKMSLSS KVSLPPIPTV SNIKSLSFPK LDSDDSSQKT VRLASTFHST SCLRSGASRN
310 320 330 340 350 360
FLKPSTQSSA SELNGDHALG LSALNLNSGT EVPALTSSQM PSLSILSVCT EESSPPSTCP
370 380 390 400 410 420
TVTPLNFSVS QVPTMPSCPQ AYLELQALSP SERQCVETVV NMGYSYDCVL RAMKKKGENI
430 440 450 460 470 480
EQILDYLFAH GQLCEKGFDP LLVEEALEMH QCSEEKMMEF LQLMSKFKEM GFELKDIKEV
490 500
LLLHNNDQDN ALEDLMARAE AS