Q8BGN6

PR
Gene name
Prrg4 (Prgp4, Tmg4)
Protein name
Transmembrane gamma-carboxyglutamic acid protein 4
Names
Proline-rich gamma-carboxyglutamic acid protein 4, Proline-rich Gla protein 4
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:228413
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

158-226 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BGN6

Entry ID Method Resolution Chain Position Source
AF-Q8BGN6-F1 Predicted AlphaFoldDB

11 variants for Q8BGN6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs28285875 23 R>K No EVA
rs3388577924 26 K>* No EVA
rs234534362 32 P>L No EVA
rs232609062 39 K>R No EVA
rs216403552 83 L>W No EVA
rs3388575330 92 F>S No EVA
rs3388568326 102 T>I No EVA
rs3391912780 110 E>G No EVA
rs28285897 134 V>L No EVA
rs265317384 135 G>S No EVA
rs3392024484 143 C>* No EVA

No associated diseases with Q8BGN6

1 regional properties for Q8BGN6

Type Name Position InterPro Accession
domain Gamma-carboxyglutamic acid-rich (GLA) domain 33 - 98 IPR000294

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum-Golgi intermediate compartment membrane The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
WW domain binding Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BZD6 PRRG4 Transmembrane gamma-carboxyglutamic acid protein 4 Homo sapiens (Human) PR
P70375 F7 Coagulation factor VII Mus musculus (Mouse) PR
10 20 30 40 50 60
MFPLLIVLSQ LPRLTLAVPH CIRSLKDSEH APEEVFASKE AANIFMHRRL LNNRFDLELF
70 80 90 100 110 120
TPGDLERECY EEFCSYEEAR EILGDDENTI KFWQTYSIKG PTTGSDVNKE KIDVMSLLTG
130 140 150 160 170 180
LIVAGVFLVI FGLVGYYVCL TKCKRRPYPS SSANYTRTAR YTPSIVFRSP EEAVLSPSTS
190 200 210 220
SEDAGLPSYE QAVALTRKHS VSPPPPYPGP ARGFRVFKKS MSLPSH