Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

4 structures for P70375

Entry ID Method Resolution Chain Position Source
5KXH X-ray 133 A B 87-126 PDB
5KY2 X-ray 147 A B 87-126 PDB
5KY3 X-ray 153 A B 87-126 PDB
AF-P70375-F1 Predicted AlphaFoldDB

19 variants for P70375

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3398670522 18 Q>P No EVA
rs3398750417 46 L>H No EVA
rs3398565728 51 P>H No EVA
rs3388967106 52 G>A No EVA
rs3388970858 110 V>A No EVA
rs3388947758 112 F>I No EVA
rs3388972067 118 E>D No EVA
rs3398815291 138 D>H No EVA
rs3398565745 139 C>S No EVA
rs3398456769 140 D>H No EVA
rs3397908547 142 Y>H No EVA
rs3388972286 180 P>L No EVA
rs3388964491 207 W>R No EVA
rs3388972274 257 K>N No EVA
rs3388972320 315 A>T No EVA
rs3398456799 325 W>C No EVA
rs3388967084 375 D>Y No EVA
rs3388964460 423 Q>H No EVA
rs3398815419 447 L>F No EVA

No associated diseases with P70375

9 regional properties for P70375

Type Name Position InterPro Accession
ptm EGF-type aspartate/asparagine hydroxylation site 102 - 113 IPR000152
domain Gamma-carboxyglutamic acid-rich (GLA) domain 23 - 87 IPR000294
domain EGF-like domain 87 - 123 IPR000742-1
domain EGF-like domain 131 - 169 IPR000742-2
domain Serine proteases, trypsin domain 193 - 433 IPR001254
domain EGF-like calcium-binding domain 87 - 123 IPR001881
conserved_site EGF-like calcium-binding, conserved site 87 - 111 IPR018097
active_site Serine proteases, trypsin family, histidine active site 230 - 235 IPR018114
active_site Serine proteases, trypsin family, serine active site 379 - 390 IPR033116

Functions

Description
EC Number 3.4.21.21 Serine endopeptidases
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
serine-type endopeptidase complex A protein complex which is capable of serine-type endopeptidase activity.
serine-type peptidase complex A protein complex which is capable of serine-type peptidase activity.
vesicle Any small, fluid-filled, spherical organelle enclosed by membrane.

4 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

30 GO annotations of biological process

Name Definition
activation of blood coagulation via clotting cascade Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot.
animal organ regeneration The regrowth of a lost or destroyed animal organ.
blood coagulation The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
blood coagulation, extrinsic pathway A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X.
blood coagulation, fibrin clot formation A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events.
blood coagulation, intrinsic pathway A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X.
circadian rhythm Any biological process in an organism that recurs with a regularity of approximately 24 hours.
positive regulation of blood coagulation Any process that activates or increases the frequency, rate or extent of blood coagulation.
positive regulation of leukocyte chemotaxis Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.
positive regulation of platelet-derived growth factor receptor signaling pathway Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
positive regulation of positive chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
positive regulation of protein kinase B signaling Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
response to 2,3,7,8-tetrachlorodibenzodioxine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus.
response to anticoagulant Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticoagulant stimulus.
response to astaxanthin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus.
response to carbon dioxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus.
response to cholesterol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
response to estradiol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
response to estrogen Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
response to genistein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus.
response to growth hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth.
response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to nutrient levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
response to Thyroid stimulating hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus.
response to thyrotropin-releasing hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.
response to thyroxine A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus.
response to vitamin K Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8BGN6 Prrg4 Transmembrane gamma-carboxyglutamic acid protein 4 Mus musculus (Mouse) PR
Q8K3U6 F7 Coagulation factor VII Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MVPQAHGLLL LCFLLQLQGP LGTAVFITQE EAHGVLHRQR RANSLLEELW PGSLERECNE
70 80 90 100 110 120
EQCSFEEARE IFKSPERTKQ FWIVYSDGDQ CASNPCQNGG TCQDHLKSYV CFCLLDFEGR
130 140 150 160 170 180
NCEKSKNEQL ICANENGDCD QYCRDHVGTK RTCSCHEDYT LQPDEVSCKP KVEYPCGRIP
190 200 210 220 230 240
VVEKRNSSSR QGRIVGGNVC PKGECPWQAV LKINGLLLCG AVLLDARWIV TAAHCFDNIR
250 260 270 280 290 300
YWGNITVVMG EHDFSEKDGD EQVRRVTQVI MPDKYIRGKI NHDIALLRLH RPVTFTDYVV
310 320 330 340 350 360
PLCLPEKSFS ENTLARIRFS RVSGWGQLLD RGATALELMS IEVPRLMTQD CLEHAKHSSN
370 380 390 400 410 420
TPKITENMFC AGYMDGTKDA CKGDSGGPHA THYHGTWYLT GVVSWGEGCA AIGHIGVYTR
430 440
VSQYIDWLVR HMDSKLQVGV FRLPLL