Q8BG81
Gene name |
Poldip3 |
Protein name |
Polymerase delta-interacting protein 3 |
Names |
S6K1 Aly/REF-like target, SKAR |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:73826 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BG81
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BG81-F1 | Predicted | AlphaFoldDB |
20 variants for Q8BG81
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389380811 | 29 | G>C | No | EVA | |
| rs3389368144 | 80 | Q>H | No | EVA | |
| rs3389387787 | 128 | P>A | No | EVA | |
| rs223291698 | 130 | A>T | No | EVA | |
| rs236898624 | 138 | T>A | No | EVA | |
| rs3389379698 | 191 | V>L | No | EVA | |
| rs13463318 | 192 | V>A | No | EVA | |
| rs3389380823 | 222 | S>F | No | EVA | |
| rs3389340507 | 242 | P>S | No | EVA | |
| rs3389393728 | 245 | V>I | No | EVA | |
| rs3389340565 | 256 | T>S | No | EVA | |
| rs3389373011 | 299 | L>I | No | EVA | |
| rs3389376252 | 305 | A>T | No | EVA | |
| rs3389368162 | 365 | L>W | No | EVA | |
| rs3389340542 | 368 | S>I | No | EVA | |
| rs3389393769 | 369 | P>L | No | EVA | |
| rs3406330576 | 379 | R>Q | No | EVA | |
| rs3389375298 | 399 | R>K | No | EVA | |
| rs3389393763 | 410 | T>S | No | EVA | |
| rs3389380780 | 412 | Q>* | No | EVA |
No associated diseases with Q8BG81
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic ribonucleoprotein granule | A ribonucleoprotein granule located in the cytoplasm. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| protein-containing complex binding | Binding to a macromolecular complex. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| poly(A)+ mRNA export from nucleus | The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. |
| positive regulation of translation | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADLSLDELI | RKRGTAAKGR | LSVRPGIGGV | RSRVGIQHSL | VNQPARTATF | QQRFDARQKI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GLSDARLKLG | VKDAREKLLQ | KDARFRIKGK | VQDAREMLNS | RKQQGTVPQK | PRQVADAREK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ISLKRRSPAA | FTSPPIGTVT | PALKLTKTIQ | VPQQKAMVPL | HAHPAGMRIN | VVNNHQAKQN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LYDLDEDDDI | VVPVPPKQMK | FAATGSLVHH | MTGLSSSKLS | MSKALPLTKV | VQNDAYTAPV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPSSVRTKAL | TSMSRTLVNK | EEPPKELPPA | EPVLSPLEGT | KMTVNNLHPR | VTEEDIVELF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CVCGALKRAR | LVHPGVAEVV | FVKKDDAITA | YKKYNNRCLD | GQPMKCNLHM | NGNVITSDQP |
| 370 | 380 | 390 | 400 | 410 | |
| ILLRLSDSPS | VKKESELPRR | GNPASSNPPA | EVDPDTVLRA | LFKSSGASVT | TQPTEFKIKL |