Q12159
Gene name |
YRA1 (YDR381W, D9481.2, D9509.1) |
Protein name |
RNA annealing protein YRA1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR381W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q12159
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5SUP | X-ray | 260 A | G/H/I | 200-226 | PDB |
| AF-Q12159-F1 | Predicted | AlphaFoldDB |
5 variants for Q12159
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-1236590 | 14 | G>D | No | SGRP | |
| s04-1236691 | 48 | P>S | No | SGRP | |
| s04-1236755 | 69 | A>V | No | SGRP | |
| s04-1237880 | 189 | P>S | No | SGRP | |
| s04-1237896 | 194 | A>V | No | SGRP |
No associated diseases with Q12159
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| transcription export complex | The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase inhibitor activity | Binds to and stops, prevents or reduces the activity of an RNA helicase. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| negative regulation of RNA helicase activity | Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent RNA helicase activity. |
| regulation of ATP-dependent activity | Any process that modulates the rate of an ATP-dependent activity. |
| transcription elongation by RNA polymerase II promoter | The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. |
| transcription-coupled nucleotide-excision repair | The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSANLDKSLD | EIIGSNKAGS | NRARVGGTRG | NGPRRVGKQV | GSQRRSLPNR | RGPIRKNTRA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPNAVARVAK | LLDTTREVKV | NVEGLPRDIK | QDAVREFFAS | QVGGVQRVLL | SYNERGQSTG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MANITFKNGE | LARRAVERFN | GSPIDGGRSR | LRLNLIVDPN | QRPVKSLADR | IKAMPQKGGN |
| 190 | 200 | 210 | 220 | ||
| APRPVKRGPN | RKAAMAKSQN | KPKREKPAKK | SLEDLDKEMA | DYFEKK |