Q8BG60
PR
Gene name |
Txnip (Vdup1) |
Protein name |
Thioredoxin-interacting protein |
Names |
Vitamin D3 up-regulated protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56338 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BG60
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BG60-F1 | Predicted | AlphaFoldDB |
12 variants for Q8BG60
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388648018 | 135 | Q>H | No | EVA | |
| rs3388650708 | 135 | Q>P | No | EVA | |
| rs3388632099 | 154 | T>S | No | EVA | |
| rs3388651813 | 174 | I>T | No | EVA | |
| rs3388650756 | 179 | V>A | No | EVA | |
| rs3388653982 | 270 | I>M | No | EVA | |
| rs240930114 | 278 | L>Q | No | EVA | |
| rs3388646451 | 333 | P>R | No | EVA | |
| rs3388632027 | 359 | S>F | No | EVA | |
| rs3393303774 | 368 | A>T | No | EVA | |
| rs3388651817 | 378 | T>I | No | EVA | |
| rs3388653194 | 395 | N>D | No | EVA |
No associated diseases with Q8BG60
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrial intermembrane space | The region between the inner and outer lipid bilayers of the mitochondrial envelope. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| enzyme inhibitor activity | Binds to and stops, prevents or reduces the activity of an enzyme. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
18 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cellular response to tumor cell | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell. |
| keratinocyte differentiation | The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. |
| negative regulation of cell division | Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| platelet-derived growth factor receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of cell population proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. |
| response to calcium ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. |
| response to estradiol | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. |
| response to glucose | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. |
| response to hydrogen peroxide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
| response to mechanical stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. |
| response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
| response to progesterone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVMFKKIKSF | EVVFNDPEKV | YGSGEKVAGR | VIVEVCEVTR | VKAVRILACG | VAKVLWMQGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QQCKQTLDYL | RYEDTLLLEE | QPTAGENEMV | IMRPGNKYEY | KFGFELPQGP | LGTSFKGKYG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CVDYWVKAFL | DRPSQPTQEA | KKNFEVMDLV | DVNTPDLMAP | VSAKKEKKVS | CMFIPDGRVS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VSARIDRKGF | CEGDDISIHA | DFENTCSRIV | VPKAAIVARH | TYLANGQTKV | FTQKLSSVRG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NHIISGTCAS | WRGKSLRVQK | IRPSILGCNI | LKVEYSLLIY | VSVPGSKKVI | LDLPLVIGSR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SGLSSRTSSM | ASRTSSEMSW | IDLNIPDTPE | APPCYMDIIP | EDHRLESPTT | PLLDDVDDSQ |
| 370 | 380 | 390 | |||
| DSPIFMYAPE | FQFMPPPTYT | EVDPCVLNNN | NNNNNVQ |