Q2HY40

PR
Gene name
TXNIP
Protein name
Thioredoxin-interacting protein
Names
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:733688
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

25-121 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2HY40

Entry ID Method Resolution Chain Position Source
AF-Q2HY40-F1 Predicted AlphaFoldDB

8 variants for Q2HY40

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1107642570 41 I>V No EVA
rs80846629 57 M>I No EVA
rs709190838 83 T>K No EVA
rs1113067864 158 A>V No EVA
rs711061956 254 S>I No EVA
rs80910183 316 E>* No EVA
rs698889971 337 I>V No EVA
rs80787892 348 T>N No EVA

No associated diseases with Q2HY40

2 regional properties for Q2HY40

Type Name Position InterPro Accession
domain Arrestin-like, N-terminal 10 - 152 IPR011021
domain Arrestin C-terminal-like domain 174 - 301 IPR011022

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
enzyme inhibitor activity Binds to and stops, prevents or reduces the activity of an enzyme.
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

9 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cellular response to tumor cell Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell.
keratinocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
negative regulation of cell division Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
platelet-derived growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H3M7 TXNIP Thioredoxin-interacting protein Homo sapiens (Human) PR
Q8BG60 Txnip Thioredoxin-interacting protein Mus musculus (Mouse) PR
Q5M7W1 Txnip Thioredoxin-interacting protein Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MVMFKKIKSF EVVFNDPEKV YGCGEKVAGR VIVEVCEVTR IKAVRILACG VAKVLWMQGS
70 80 90 100 110 120
QQCKQTLDYL RYEDTLLLDD HPTGENEMVI MRPGNKYEYK FGFELPQGPL GTSFKGKYGC
130 140 150 160 170 180
VDYWVKAFLD RPSQPTQETK KHFEVMDLVD VNTPDLMAPV SAKKEKKVSC MFIPDGRVSV
190 200 210 220 230 240
SARIDRKGFC EGDEINIHAD FENTCSRIVV PKAAIVARHT YLANGQTKVL TQKLSSVRGN
250 260 270 280 290 300
HIISGTCASW RGKSLRVQKI RPSILGCNIL RVEYFLLIYV SVPGSKKVIL DLPLVIGSRS
310 320 330 340 350 360
GLSSRTSSMA SRTSSEMSWV DLNIPDTPEA PPCYMDIIPE DHRLESPTTP LLDDTDGSQD
370 380 390
SPIFMYAPEF KFMPPPTYSE VDPCILNNNV Q