AiPD: Autoinhibited Protein Database

Q86UT8

Gene name	CENATAC
Protein name	Centrosomal AT-AC splicing factor
Names	Coiled-coil domain-containing protein 84
Species	Homo sapiens (Human)
KEGG Pathway	hsa:338657
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-70 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-70 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q86UT8

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q86UT8-F1	Predicted				AlphaFoldDB

338 variants for Q86UT8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA6310610 rs781824691	2	A>P		No	ExAC gnomAD ClinGen
rs1565655067 CA382912035	4	A>V		No	ClinGen Ensembl
rs910925018 CA229638586	5	Q>*		No	TOPMed ClinGen
rs781993939 CA229638590	6	R>C		No	ClinGen TOPMed gnomAD
rs1565655102 CA382912061	6	R>H		No	ClinGen Ensembl
CA382912054 rs781993939	6	R>S		No	TOPMed gnomAD ClinGen
rs1291734519 CA382912066	7	C>S		No	TOPMed ClinGen
CA6310612 rs782630034	7	C>W		No	ExAC TOPMed gnomAD ClinGen
CA229638595 rs1043498787	7	C>Y		No	TOPMed gnomAD ClinGen
rs1336743266 CA382912090	8	P>L		No	TOPMed gnomAD ClinGen
CA6310614 rs1016045617	8	P>S		No	TOPMed ClinGen
CA382912081 rs1016045617	8	P>T		No	TOPMed ClinGen
rs373158845 CA6310616	9	L>V		No	ESP ExAC TOPMed gnomAD ClinGen
CA382912105 rs1486222603	10	C>Y		No	ClinGen gnomAD
rs782696702 CA6310617	11	R>C		No	ClinGen ExAC gnomAD
rs782696702 CA382912115	11	R>G		No	ExAC gnomAD ClinGen
CA229638666 rs867717095	11	R>H		No	Ensembl ClinGen
CA382912128 rs1461516194	12	Q>H		No	TOPMed ClinGen
rs200075860 CA6310619	13	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1185430081 CA382912142	13	T>N		No	ClinGen TOPMed
CA382912159 rs1251634838	14	F>S		No	ClinGen TOPMed
rs782106623 CA6310623	18	R>C		No	ClinGen ExAC gnomAD
rs782106623 CA6310622	18	R>S		No	ClinGen ExAC gnomAD
CA382912233 rs1179338618	19	G>W		No	ClinGen TOPMed
rs1592041243 CA382912289	21	V>F		No	ClinGen Ensembl
rs199921161 CA229638736	22	Y>S		No	ClinGen Ensembl
CA382912344 rs782053254	24	R>H		No	ExAC TOPMed gnomAD ClinGen
CA6310625 COSM3808519 rs782053254	24	R>L	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs782804370 CA6310626	25	K>Q		No	ExAC gnomAD ClinGen
CA6310627 rs781888190	25	K>R		No	ClinGen ExAC gnomAD
CA6310628 rs782132763	27	Q>*		No	ExAC gnomAD ClinGen
rs1592041302 CA382912399	27	Q>H		No	Ensembl ClinGen
rs782132763 CA6310629	27	Q>K		No	ClinGen ExAC gnomAD
rs896062537 CA229638753	28	R>G		No	ClinGen TOPMed
CA382912419 rs1184993451	28	R>Q		No	TOPMed gnomAD ClinGen
CA382912429 rs1395073979	29	Q>*		No	ClinGen gnomAD
CA229638773 rs918885747	32	E>A		No	ClinGen Ensembl
CA6310631 rs782460921	32	E>K		No	ClinGen ExAC gnomAD
rs1287515003 CA382912581	36	R>G		No	gnomAD ClinGen
rs1317401752 CA382912587	36	R>K		No	ClinGen TOPMed gnomAD
CA6310632 rs782589885	36	R>S		No	ClinGen ExAC gnomAD
CA382912605 rs1254265344	37	L>H		No	gnomAD ClinGen
CA229638788 rs1044379492	37	L>V		No	ClinGen TOPMed
CA6310634 rs782555307	39	P>L		No	ClinGen ExAC TOPMed gnomAD
CA382912632 rs372983214	39	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6310633 rs372983214	39	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1471804365 CA382912648	40	Q>*		No	TOPMed gnomAD ClinGen
CA382912644 rs1471804365	40	Q>K		No	TOPMed gnomAD ClinGen
rs1592041414 CA382912649	40	Q>P		No	ClinGen Ensembl
rs201382314 CA6310657	41	V>G		No	ExAC gnomAD ClinGen
rs1427356997 CA382912710	41	V>M		No	TOPMed gnomAD ClinGen
CA6310659 rs782641930	42	E>G		No	ClinGen ExAC gnomAD
rs1366764368 CA382912734	43	A>G		No	gnomAD ClinGen
CA6310660 rs782243265	43	A>T		No	ClinGen ExAC gnomAD
CA382912748 rs1305638930	45	R>C		No	gnomAD ClinGen
rs562464017 CA382912749	45	R>H		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs562464017 CA6310663	45	R>L		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA382912754 rs562464017	45	R>P		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA382912792 rs1274024284	47	A>S		No	gnomAD ClinGen
rs782031776 CA6310665	49	R>G		No	ExAC TOPMed gnomAD ClinGen
rs370851953 CA6310666	49	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs370851953 CA382912822	49	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA382912833 rs1455927254	50	A>S		No	TOPMed ClinGen
rs1469249886 CA382912840	50	A>V		No	gnomAD ClinGen
CA229638971 rs781975206	51	A>P		No	ExAC TOPMed gnomAD ClinGen
rs781975206 CA6310668	51	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs782088897 CA6310669	52	Q>R		No	ExAC TOPMed gnomAD ClinGen
rs1592042028 CA382912893	53	V>G		No	ClinGen Ensembl
rs782720687 CA6310670	53	V>L		No	ClinGen ExAC gnomAD
CA6310672 rs574488069	55	R>P		No	1000Genomes ExAC gnomAD ClinGen
CA6310673 rs782554719	56	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA382912934 rs782554719	56	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs1411325072 CA382912942	57	V>M		No	gnomAD ClinGen
rs541867889 CA6310674	58	P>A		No	ClinGen 1000Genomes ExAC gnomAD
rs541867889 CA382912964	58	P>S		No	1000Genomes ExAC gnomAD ClinGen
rs923703174 CA229639025	61	E>G		No	TOPMed ClinGen
rs782494985 CA382912997	62	R>L		No	ClinGen ExAC TOPMed gnomAD
rs782494985 CA6310676	62	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs527454301 CA6310677	64	C>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA382913028 rs1430160813	65	W>R		No	TOPMed gnomAD ClinGen
rs782205675 CA6310678	65	W>S		No	ExAC TOPMed gnomAD ClinGen
CA382913042 rs1200927310	66	C>G		No	ClinGen Ensembl
CA382913065 rs782453291	68	C>F		No	ExAC gnomAD ClinGen
rs782453291 CA6310679	68	C>Y		No	ExAC gnomAD ClinGen
rs917425937 CA229639066	70	G>D		No	ClinGen TOPMed
CA229639069 rs148851960	71	C>W		No	ClinGen Ensembl
CA6310680 rs782747146	72	E>V		No	ClinGen ExAC TOPMed gnomAD
CA382913120 rs1592042191	73	V>G		No	Ensembl ClinGen
rs374336321 CA6310681	73	V>L		No	ClinGen ESP ExAC TOPMed
CA382913130 rs1359523573	74	R>Q		No	ClinGen TOPMed
rs1592042225 CA382913141	75	E>G		No	Ensembl ClinGen
rs782402353 CA6310683	75	E>K		No	ExAC TOPMed gnomAD ClinGen
CA382913172 rs1216091161	78	S>N		No	ClinGen gnomAD
CA6310684 rs368727870	79	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA229639088 rs1044681005	80	G>R		No	TOPMed gnomAD ClinGen
CA382913239 rs1242228685	83	T>M		No	gnomAD ClinGen
CA229639104 rs1013120401	84	V>A		No	Ensembl ClinGen
rs1179773060 CA382913243	84	V>M		No	gnomAD ClinGen
CA229639107 rs1016843588	85	L>P		No	TOPMed ClinGen
CA229639147 rs372399464	86	Y>*		No	ESP TOPMed ClinGen
CA382913265 rs1374906177	86	Y>H		No	ClinGen TOPMed
rs781789455 CA6310687	86	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA382913286 rs1166977129	87	G>A		No	gnomAD ClinGen
rs782050456 CA382913280	87	G>R		No	ExAC TOPMed gnomAD ClinGen
rs782050456 CA6310688	87	G>W		No	ExAC TOPMed gnomAD ClinGen
rs552070057 CA6310689	88	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1446073278 CA382913329	91	E>G		No	ClinGen TOPMed gnomAD
rs782135781 CA6310692	92	H>Q		No	ExAC gnomAD ClinGen
rs782765437 CA6310693	93	L>P		No	ClinGen ExAC gnomAD
CA382913381 rs1329036916	94	A>S		No	ClinGen gnomAD
rs782100370 CA6310709	99	K>T		No	ClinGen ExAC gnomAD
rs140617350 CA6310710	102	T>I		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA6310712 rs373436467	103	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA6310711 rs781938150	103	N>S		No	ClinGen ExAC TOPMed gnomAD
rs782816552 CA6310713	105	F>L		No	ClinGen ExAC gnomAD
rs1329813775 CA382913703	106	W>*		No	TOPMed gnomAD ClinGen
CA229639564 rs1006668326	107	W>*		No	TOPMed ClinGen
rs1440820230 CA382913734	107	W>*		No	ClinGen gnomAD
rs977907421 CA229639570	111	A>T		No	Ensembl ClinGen
rs1301986103 CA382913873	112	E>D		No	TOPMed gnomAD ClinGen
rs1312142717 CA382913883	113	V>F		No	TOPMed ClinGen
rs1316473732 CA382913908	114	Q>H		No	gnomAD ClinGen
TCGA novel	115	M>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6310715 rs782126485	116	K>T		No	ExAC ClinGen
CA382913959 rs1273748323	117	E>Q		No	TOPMed ClinGen
rs141547874 CA229639576	118	K>*		No	ClinGen ESP
rs782756241 CA6310716	119	F>L		No	ClinGen ExAC gnomAD
CA229639583 rs782447292	121	V>F		No	ClinGen gnomAD
CA382914045 rs782447292	121	V>I		No	gnomAD ClinGen
rs1196110844 CA382914090	123	P>S		No	ClinGen gnomAD
CA382914140 rs1274895986	125	D>N		No	gnomAD ClinGen
CA6310719 rs375803206	128	R>*		No	ESP ExAC gnomAD ClinGen
rs1160272095 CA382917289	129	F>L		No	TOPMed ClinGen
CA382917298 rs1317567796	130	K>R		No	TOPMed gnomAD ClinGen
CA6310743 rs199859594	131	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1260036760 CA382917387	133	M>I		No	ClinGen TOPMed gnomAD
CA382917382 rs1211882965	133	M>T		No	ClinGen gnomAD
rs782564969 CA6310745	133	M>V		No	ClinGen ExAC gnomAD
rs1378157960 CA382917411	134	V>A		No	TOPMed ClinGen
rs1565667385 CA382917430	136	G>R		No	ClinGen Ensembl
TCGA novel	136	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs973574569 CA229653615	138	D>G		No	ClinGen Ensembl
rs920308063 CA229653646	139	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs189873299 CA6310747	140	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs189873299 CA382917542	140	Y>F		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA6310748 rs782655248	141	E>G		No	ExAC TOPMed gnomAD ClinGen
TCGA novel	143	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA229653668 rs983112742	144	E>K		No	TOPMed gnomAD ClinGen
CA382917706 rs983112742	144	E>Q		No	ClinGen TOPMed gnomAD
CA229653671 rs911845324	145	D>N		No	ClinGen TOPMed
TCGA novel	149	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6310750 rs782350954	150	E>A		No	ClinGen ExAC
rs550351597 CA229653676	150	E>Q		No	ClinGen 1000Genomes
CA6310776 rs781932545	152	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs995447159 CA229654168	153	A>T		No	ClinGen Ensembl
CA382918242 rs1309697430	154	Q>P		No	gnomAD ClinGen
rs202215150 CA6310778	156	R>C		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs782301681 CA6310779	156	R>H		No	ExAC TOPMed gnomAD ClinGen
CA382918369 rs1592073074	158	V>G		No	Ensembl ClinGen
rs782128788 CA6310780	158	V>M		No	ClinGen ExAC TOPMed gnomAD
CA229654207 rs782016648	161	S>N		No	ClinGen gnomAD
CA6310782 rs200584267	161	S>R		No	1000Genomes ExAC gnomAD ClinGen
rs1419960688 CA382918465	162	R>*		No	ClinGen gnomAD
rs369310743 CA6310783	162	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs782719153 CA6310784	163	Q>H		No	ExAC gnomAD ClinGen
CA382918513 rs1461926206	164	E>D		No	TOPMed gnomAD ClinGen
rs781908854 CA6310785	164	E>Q		No	ClinGen ExAC
rs782647917 CA6310786	164	E>V		No	ClinGen ExAC gnomAD
CA382918555 rs1592073154	165	V>G		No	Ensembl ClinGen
rs1452130998 CA382918580	166	V>A		No	ClinGen TOPMed
rs782655675 CA6310787	166	V>L		No	ExAC TOPMed gnomAD ClinGen
CA6310790 rs782492332	167	R>L		No	ExAC TOPMed gnomAD ClinGen
COSM1200064 CA6310789 rs782492332	167	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6310788 COSM131121 rs781857579	167	R>W	liver [Cosmic]	No	ExAC TOPMed gnomAD ClinGen cosmic curated
rs782306579 CA6310792	168	S>Y		No	ExAC gnomAD ClinGen
CA382918677 rs782271351	170	L>*		No	ClinGen ExAC gnomAD
CA6310793 rs782690439	170	L>I		No	ExAC gnomAD ClinGen
rs782271351 CA6310794	170	L>S		No	ClinGen ExAC gnomAD
CA6310815 rs782236727	172	P>L		No	ExAC gnomAD ClinGen
CA382918968 rs1226495293	174	A>G		No	TOPMed ClinGen
rs1231053757 CA382918992	175	V>L		No	gnomAD ClinGen
CA6310816 rs782479215	176	P>A		No	ExAC gnomAD ClinGen
CA6310817 rs145295890	177	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1177787213 CA382919034	177	D>N		No	ClinGen gnomAD
CA6310819 rs782193641	178	P>A		No	ClinGen ExAC TOPMed gnomAD
rs782193641 CA6310818	178	P>T		No	ExAC TOPMed gnomAD ClinGen
CA382919071 rs1565668681	179	E>K		No	Ensembl ClinGen
rs1397667999 CA382919150	181	G>V		No	ClinGen TOPMed
rs1327297487 CA382919236	185	P>R		No	gnomAD ClinGen
CA382919233 rs1416567961	185	P>S		No	gnomAD ClinGen
rs782023120 CA6310821	188	W>*		No	ClinGen ExAC TOPMed gnomAD
CA6310822 rs782265485	192	N>H		No	ExAC gnomAD ClinGen
rs782448786 CA229658401	194	Q>H		No	ClinGen ExAC gnomAD
CA382919905 rs1592075422	195	V>A		No	Ensembl ClinGen
rs147652491 CA6310836	195	V>L		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs1467102265 CA382919926	196	A>G		No	gnomAD ClinGen
CA6310837 rs782285037	196	A>T		No	ExAC gnomAD ClinGen
rs1565668906 CA382919937	197	S>C		No	Ensembl ClinGen
rs1565668906 CA382919936	197	S>Y		No	ClinGen Ensembl
rs782524411 CA6310839	199	L>F		No	ExAC TOPMed gnomAD ClinGen
rs1438385143 CA382919989	200	Q>*		No	ClinGen TOPMed
CA382920036 rs1565668956	201	Q>*		No	ClinGen Ensembl
rs782632466 CA6310840	203	S>L		No	ClinGen ExAC gnomAD
rs782340360 CA382920119	205	L>V		No	ClinGen ExAC TOPMed gnomAD
CA382920160 rs1592075516	206	D>A		No	Ensembl ClinGen
rs1041006327 CA229658430	210	A>T		No	ClinGen TOPMed gnomAD
rs1416247205 CA382920249	212	E>G		No	ClinGen gnomAD
CA6310844 rs781940512	212	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA382920313 rs1189245923	215	W>*		No	TOPMed ClinGen
CA382920324 rs1324580527	216	M>L		No	ClinGen TOPMed gnomAD
CA382920321 rs1324580527	216	M>V		No	ClinGen TOPMed gnomAD
CA382920390 rs1390891414	218	T>K		No	gnomAD ClinGen
rs535130498 CA6310845	220	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA382920433 rs1315868025	221	S>F		No	gnomAD ClinGen
rs1325626359 CA382920459	223	T>R		No	gnomAD ClinGen
rs782426189 CA6310846	224	F>L		No	ExAC gnomAD ClinGen
CA6310847 rs782017698	225	I>N		No	ClinGen ExAC TOPMed gnomAD
CA6310848 rs782017698	225	I>T		No	ClinGen ExAC TOPMed gnomAD
CA229658440 rs782758434	225	I>V		No	Ensembl ClinGen
CA382920507 rs1232622451	226	G>D		No	TOPMed gnomAD ClinGen
CA382920515 rs1358608182	227	H>N		No	TOPMed gnomAD ClinGen
CA382920526 rs1298808550	227	H>R		No	TOPMed ClinGen
rs781960489	228	Q>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA6310884 rs563859324	229	D>N		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA382920713 rs1253482551	230	I>V		No	TOPMed ClinGen
rs1377797305 CA382920725	231	P>T		No	gnomAD ClinGen
CA382920752 rs1242582285	233	V>I		No	gnomAD ClinGen
rs1260361812 CA382920781	235	N>D		No	TOPMed ClinGen
CA382920786 rs76783804	235	N>S		No	ExAC gnomAD ClinGen
CA6310885 rs76783804	235	N>T		No	ExAC gnomAD ClinGen
CA6310888 rs782488014	237	H>R		No	ClinGen ExAC gnomAD
CA229659742 rs200747735	238	S>L		No	ClinGen 1000Genomes TOPMed
rs782184217 CA6310931	240	A>D		No	ExAC gnomAD ClinGen
CA382921410 rs1437413390	240	A>T		No	ClinGen gnomAD
CA6310932 rs782421169	242	P>T		No	ClinGen ExAC TOPMed gnomAD
rs600648 VAR_029848 CA229661625	244	W>G		No	ClinGen UniProt Ensembl dbSNP
rs782018753 CA6310933	246	I>F		No	ClinGen ExAC TOPMed gnomAD
rs375235213 CA229661627	246	I>N		No	ESP TOPMed ClinGen
rs560685835 CA229661629	247	Q>K		No	1000Genomes TOPMed ClinGen
CA382921529 rs1226508896	248	D>N		No	ClinGen TOPMed
rs143147723 CA6310935	249	E>D		No	ESP ExAC TOPMed gnomAD ClinGen
CA382921552 rs1320566609	249	E>K		No	TOPMed gnomAD ClinGen
TCGA novel	251	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6310938 rs781967187	252	I>S		No	ClinGen ExAC gnomAD
rs1320663036 CA382921595	252	I>V		No	ClinGen gnomAD
CA382921627 rs1484691160	254	G>E		No	ClinGen gnomAD
rs782077969 CA6310939	254	G>R		No	ClinGen ExAC TOPMed gnomAD
CA382921652 rs527738305	256	Q>*		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs527738305 CA6310940	256	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6310941 rs527738305	256	Q>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6310942 rs552747259	256	Q>R		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA6310943 rs782791132	257	E>K		No	ClinGen ExAC TOPMed gnomAD
rs371797960 CA229661681	258	I>R		No	ClinGen TOPMed
CA229661676 rs371797960	258	I>T		No	TOPMed ClinGen
CA382921705 rs1184656764	259	G>E		No	ClinGen TOPMed
CA6310946 CA229661690 rs782502920	259	G>R		No	ExAC TOPMed gnomAD ClinGen
rs1343618505 CA382921711	260	P>T		No	ClinGen gnomAD
CA6310948 rs781811320	261	S>F		No	ClinGen ExAC gnomAD
rs782437414 COSM923694 CA6310949	264	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ExAC TOPMed gnomAD ClinGen cosmic curated NCI-TCGA
TCGA novel	265	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382921836 rs1413470102	266	L>F		No	gnomAD ClinGen
CA382921833 COSM428528 rs1413470102	266	L>V	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	gnomAD ClinGen cosmic curated NCI-TCGA
CA382921843 rs899354415	267	K>*		No	ClinGen TOPMed gnomAD
CA229661695 rs899354415	267	K>E		No	TOPMed gnomAD ClinGen
rs370905829 CA6310952	268	E>G		No	ClinGen ESP TOPMed gnomAD
rs782685571 CA6310951	268	E>K		No	ClinGen ExAC gnomAD
rs370905829 CA382921889	268	E>V		No	ESP TOPMed gnomAD ClinGen
CA229661705 rs782423969	269	K>Q		No	ClinGen Ensembl
CA382922685 rs1295922796	270	E>K		No	ClinGen TOPMed
CA229661911 rs1008873254	271	K>E		No	ClinGen TOPMed
rs975544597 CA229661914	271	K>R		No	TOPMed gnomAD ClinGen
rs1555187647 CA6310994	272	Q>H		No	ClinGen Ensembl
CA232401 RCV000122595 rs386352288	272	Q>R		No	ClinGen ClinVar Ensembl dbSNP
rs1220864017 CA382922867	273	K>R		No	ClinGen gnomAD
CA6310998 rs782404744	274	L>V		No	ExAC TOPMed gnomAD ClinGen
CA229661928 rs964767391	277	L>I		No	TOPMed gnomAD ClinGen
rs782120998 CA6311000	277	L>P		No	ClinGen ExAC TOPMed
TCGA novel	278	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA229661930 rs868712764	278	P>T		No	Ensembl ClinGen
rs781823420 CA6311002	279	P>L		No	ClinGen ExAC TOPMed gnomAD
rs781823420 CA6311003	279	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs373690810 CA6311001	279	P>S		No	ESP ExAC TOPMed gnomAD ClinGen
rs782705067 CA6311004	280	D>E		No	ExAC gnomAD ClinGen
CA382923049 rs1448653955	280	D>H		No	ClinGen TOPMed
rs1214317268	280	D>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	280	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6311005 rs367702790	281	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs371758182 CA382923073	281	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6311006 rs371758182	281	R>Q		No	ESP ExAC TOPMed gnomAD ClinGen
rs782477975 CA6311009	282	V>A		No	ExAC gnomAD ClinGen
rs782477975 CA382923111	282	V>G		No	ExAC gnomAD ClinGen
CA6311008 rs543989276	282	V>I		No	1000Genomes ExAC gnomAD ClinGen
rs1489079752 CA382923115	283	G>R		No	ClinGen gnomAD
rs1209660225 CA382923166	284	A>V		No	ClinGen gnomAD
rs782424650 CA382923225	286	F>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs782424650 CA6311012	286	F>Y		No	ClinGen ExAC TOPMed gnomAD
rs1276105829 CA382923381	291	R>S		No	gnomAD ClinGen
CA382923428 rs1178800001	293	S>R		No	ClinGen gnomAD
CA382923476 rs1272926948	295	G>D		No	ClinGen TOPMed
rs782382177 CA6311015	297	L>P		No	ExAC TOPMed gnomAD ClinGen
rs781970005 CA6311016	299	S>A		No	ClinGen ExAC gnomAD
TCGA novel	300	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1379155736 CA382923558	300	F>Y		No	gnomAD ClinGen
rs782081346 CA6311017	302	R>C		No	ExAC TOPMed gnomAD ClinGen
rs782325490 CA6311018	302	R>H		No	ExAC TOPMed gnomAD ClinGen
rs782325490 CA6311019	302	R>P		No	ExAC TOPMed gnomAD ClinGen
rs1191430788 CA382923631	303	V>I		No	TOPMed gnomAD ClinGen
rs782778637 CA6311021	304	W>R		No	ExAC gnomAD ClinGen
CA6311023 rs782106751	305	N>K		No	ExAC gnomAD ClinGen
rs150323701 CA6311022	305	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200160466 CA6311024	308	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6311025 rs782098408	308	R>H		No	ExAC TOPMed gnomAD ClinGen
CA6311026 rs137880438	309	R>C		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs1164892799 CA382923735	310	W>*		No	TOPMed ClinGen
rs1296094282 CA382923770	311	Q>H		No	ClinGen TOPMed gnomAD
CA6311028 rs782818395	313	R>G		No	ExAC gnomAD ClinGen
CA229661995 rs941039501	313	R>K		No	ClinGen TOPMed
CA6311052 rs377583343	314	H>Y		No	ESP ExAC TOPMed gnomAD ClinGen
CA382923944 rs1220020580	317	K>R		No	TOPMed ClinGen
TCGA novel	318	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782677187 CA6311056	320	A>T		No	ExAC gnomAD ClinGen
rs1256236275 CA382924011	320	A>V		No	ClinGen gnomAD
CA6311057 rs200262306	321	A>V		No	ExAC gnomAD ClinGen
CA6311058 rs568817363	322	A>G		No	1000Genomes ExAC gnomAD ClinGen
rs1176255213 CA382924034	322	A>T		No	ClinGen gnomAD
rs782223204 CA6311061	323	M>I		No	ExAC gnomAD ClinGen
rs1565673790 CA382924058	323	M>K		No	ClinGen Ensembl
CA6311059 rs181791793	323	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs186379534 CA6311062	324	K>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6311063 rs781934290	325	K>Q		No	ExAC TOPMed gnomAD ClinGen
CA6311064 rs782292570	326	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs996009597 CA229662052	327	S>P		No	Ensembl ClinGen
CA382924201 CA6311069 rs782124473	330	E>D		No	ClinGen ExAC TOPMed gnomAD
rs782013262 CA6311068	330	E>G		No	ClinGen ExAC TOPMed gnomAD
CA6311070 rs782367365	331	K>R		No	ExAC gnomAD ClinGen
TCGA novel	332	S>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781792161 CA6311065	333	S>C		No	ExAC TOPMed gnomAD ClinGen
CA382924247 rs375684853	333	S>S		No	ClinGen ESP ExAC gnomAD

No associated diseases with Q86UT8

No regional properties for Q86UT8

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q86UT8

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	Localizes to the proximal end of the mother centriole During the cell cycle, from G1 to metaphase, gradually accumulates on the centrosome and then decreased significantly upon entry into anaphase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name	Definition
negative regulation of centrosome duplication	Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
regulation of protein catabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q4VA36	Cenatac	Centrosomal AT-AC splicing factor	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAPAQRCPLC	RQTFFCGRGH	VYSRKHQRQL	KEALERLLPQ	VEAARKAIRA	AQVERYVPEH
70	80	90	100	110	120
ERCCWCLCCG	CEVREHLSHG	NLTVLYGGLL	EHLASPEHKK	ATNKFWWENK	AEVQMKEKFL
130	140	150	160	170	180
VTPQDYARFK	KSMVKGLDSY	EEKEDKVIKE	MAAQIREVEQ	SRQEVVRSVL	EPQAVPDPEE
190	200	210	220	230	240
GSSAPRSWKG	MNSQVASSLQ	QPSNLDLPPA	PELDWMETGP	SLTFIGHQDI	PGVGNIHSGA
250	260	270	280	290	300
TPPWMIQDEE	YIAGNQEIGP	SYEEFLKEKE	KQKLKKLPPD	RVGANFDHSS	RTSAGWLPSF
310	320	330
GRVWNNGRRW	QSRHQFKTEA	AAMKKQSHTE	KS