Q4VA36
Gene name |
Cenatac (Ccdc84) |
Protein name |
Centrosomal AT-AC splicing factor |
Names |
Coiled-coil domain-containing protein 84 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:382073 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4VA36
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4VA36-F1 | Predicted | AlphaFoldDB |
22 variants for Q4VA36
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389042828 | 5 | Q>K | No | EVA | |
| rs3389027417 | 7 | C>Y | No | EVA | |
| rs3389014448 | 12 | Q>H | No | EVA | |
| rs212058542 | 29 | Q>L | No | EVA | |
| rs3389040321 | 60 | H>Y | No | EVA | |
| rs3389046221 | 69 | C>Y | No | EVA | |
| rs3389046271 | 83 | T>I | No | EVA | |
| rs3389040373 | 137 | L>M | No | EVA | |
| rs3388988712 | 159 | E>V | No | EVA | |
| rs3389027407 | 161 | S>I | No | EVA | |
| rs3389040299 | 187 | S>C | No | EVA | |
| rs32608788 | 190 | A>V | No | EVA | |
| rs3389045201 | 194 | H>L | No | EVA | |
| rs246574577 | 214 | D>E | No | EVA | |
| rs3389039596 | 220 | Q>K | No | EVA | |
| rs3400190837 | 245 | M>I | No | EVA | |
| rs3389039566 | 247 | Q>* | No | EVA | |
| rs213011080 | 247 | Q>P | No | EVA | |
| rs3389040499 | 251 | H>Q | No | EVA | |
| rs3389027383 | 271 | K>Q | No | EVA | |
| rs3389040339 | 273 | K>T | No | EVA | |
| rs3400062918 | 283 | G>V | No | EVA |
No associated diseases with Q4VA36
No regional properties for Q4VA36
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q4VA36 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of centrosome duplication | Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. |
| regulation of protein catabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q86UT8 | CENATAC | Centrosomal AT-AC splicing factor | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPPQRCPLC | RQTFFCGRGH | VYSHKHQRQL | KGALERLLPQ | VEAARRAVRA | AQVERYVPEH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DRCCWCPCCG | CEVRKHLSHG | NLTVLHGGLL | EHLASPEHKK | ATNKFWWENK | ANAQMKEKFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ISPQDYARFK | KSMVKGLDSY | EEKEDEVIKE | MAAQIREVEQ | SRQEVVRSVL | EPQAESDPEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GSSAPESWKA | TNGHVASSSQ | QVSHLALQPV | AELDWMETGQ | QLTFIGHQDT | PGIGNIHSGA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TPPWMIQEEE | HSSGSLPIGP | SYEEFLKEKE | KQKLKKLPPD | RVGANFDHSS | NTSAGWLPSF |
| 310 | 320 | 330 | |||
| GRVWNNGRRW | QSRHQFKTEA | ATRSKQPRKG | KS |