AiPD: Autoinhibited Protein Database

Q86UL3

Gene name	GPAT4
Protein name	Glycerol-3-phosphate acyltransferase 4
Names	1-acylglycerol-3-phosphate O-acyltransferase 6, 1-AGP acyltransferase 6, 1-AGPAT 6, Acyl-CoA:glycerol-3-phosphate acyltransferase 4, Lysophosphatidic acid acyltransferase zeta, LPAAT-zeta, Testis spermatogenesis apoptosis-related protein 7, TSARG7
Species	Homo sapiens (Human)
KEGG Pathway	hsa:137964
EC number	2.3.1.15: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

32-136 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

32-136 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q86UL3

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q86UL3-F1	Predicted				AlphaFoldDB

251 variants for Q86UL3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs534990402 CA4726461	2	F>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201982831 CA4726462	9	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA4726463 rs777623777	11	I>M		No	ClinGen ExAC gnomAD
CA4726464 rs749192194	12	V>F		No	ClinGen ExAC TOPMed gnomAD
rs554740180 CA4726465	13	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1585660191 CA371043442	17	I>L		No	ClinGen Ensembl
rs745525354 CA4726468	21	V>I		No	ClinGen ExAC gnomAD
CA371043491 rs1329560534	22	L>F		No	ClinGen TOPMed
CA371043490 rs1329560534	22	L>V		No	ClinGen TOPMed
rs1585660222 CA371043510	24	T>P		No	ClinGen Ensembl
rs1361225602 CA371043530	26	L>I		No	ClinGen gnomAD
TCGA novel	27	L>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760142023 CA4726471	27	L>F		No	ClinGen ExAC gnomAD
CA4726473 rs375002166	28	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA4726474 rs762266933	30	I>V		No	ClinGen ExAC gnomAD
COSM1182229 rs765600184 CA4726475	31	I>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA371043581 rs1384211933	31	I>V		No	ClinGen TOPMed
TCGA novel	32	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768242581 CA175907167	34	A>V		No	ClinGen Ensembl
CA371043635 rs1280533019	37	G>R		No	ClinGen gnomAD
rs1585660295 CA371043671	42	I>T		No	ClinGen Ensembl
CA175907179 rs969162986	42	I>V		No	ClinGen gnomAD
CA4726480 rs755038220	43	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA175907183 rs866666749 COSM486468	43	R>H	kidney Variant assessed as Somatic; impact. central_nervous_system endometrium prostate [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA371043696 rs1243226268	46	Y>C		No	ClinGen gnomAD
rs781295731 CA4726481	47	M>T		No	ClinGen ExAC gnomAD
CA371043709 rs1301317642	48	K>E		No	ClinGen TOPMed gnomAD
TCGA novel	49	S>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	50	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	53	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778977102 CA4726484	55	A>V		No	ClinGen ExAC gnomAD
rs1372109334 CA371045995	61	M>I		No	ClinGen TOPMed
rs1275622185 CA371045976	61	M>T		No	ClinGen gnomAD
CA175911517 rs866267744	62	E>Q		No	ClinGen gnomAD
TCGA novel	63	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4726507 rs377030711	63	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA371046105 rs1236795465	67	E>Q		No	ClinGen gnomAD
CA4726508 rs747697851	69	N>K		No	ClinGen ExAC gnomAD
rs1182090751 CA371046191	71	Q>*		No	ClinGen gnomAD
rs1166503660 CA371046209	72	L>F		No	ClinGen TOPMed
CA175911527 rs962349795	75	P>L		No	ClinGen Ensembl
rs1367474784 CA371046291	77	T>P		No	ClinGen gnomAD
CA371046376 rs1276884119	79	G>A		No	ClinGen gnomAD
CA371046319 rs1563276951	79	G>R		No	ClinGen Ensembl
rs772540537 CA4726532	84	D>V		No	ClinGen ExAC gnomAD
CA4726533 rs775875846	85	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA371046525 rs1343293234	87	S>L		No	ClinGen gnomAD
rs1327307604 CA371046540	88	L>V		No	ClinGen TOPMed
TCGA novel	89	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371046665 rs1288022006	92	I>M		No	ClinGen TOPMed
rs985928396 CA175911610	93	K>E		No	ClinGen TOPMed
rs1280514007 CA371046678	93	K>R		No	ClinGen gnomAD
CA175911612 rs755071830 COSM1099839	96	R>C	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA175911613 rs372267172	96	R>H		No	ClinGen ESP gnomAD
rs781072925 CA175911615	97	R>P		No	ClinGen ExAC TOPMed gnomAD
rs781072925 CA4726536	97	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4726537 rs761795294	98	S>I		No	ClinGen ExAC gnomAD
rs751431517 CA4726539	99	G>D		No	ClinGen ExAC gnomAD
rs557789924 CA4726538	99	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1375787922 CA371046782	101	S>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs759349840 CA4726540	101	S>N		No	ClinGen ExAC gnomAD
rs759349840 CA371046784	101	S>T		No	ClinGen ExAC gnomAD
TCGA novel	102	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371046803 rs1204002620	103	A>T		No	ClinGen gnomAD
CA371046814 rs1175774828	104	L>M		No	ClinGen gnomAD
CA4726541 rs767261622	104	L>P		No	ClinGen ExAC gnomAD
CA4726542 rs752353760	105	D>G		No	ClinGen ExAC gnomAD
CA175911634 rs934038413	105	D>N		No	ClinGen TOPMed
CA371046881 rs1287235071	106	N>S		No	ClinGen gnomAD
CA4726543 rs755709726	109	E>D		No	ClinGen ExAC TOPMed gnomAD
rs753450693 CA371046974	111	E>*		No	ClinGen ExAC gnomAD
CA4726545 rs753450693	111	E>K		No	ClinGen ExAC gnomAD
CA371047020 rs1563277120	114	D>N		No	ClinGen Ensembl
rs1236875142 CA371047053	115	I>V		No	ClinGen gnomAD
rs779520353 CA175911658	120	R>L		No	ClinGen ExAC TOPMed gnomAD
rs779520353 COSM1489289 CA4726547	120	R>Q	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1352474249 CA371047162	120	R>W		No	ClinGen gnomAD
CA371047197 rs1585670074	122	G>R		No	ClinGen Ensembl
rs746325761 CA4726548	123	M>I		No	ClinGen ExAC gnomAD
CA371047285 rs1563277144	126	I>V		No	ClinGen Ensembl
TCGA novel	133	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371047457 rs1427633989	137	A>P		No	ClinGen TOPMed
CA4726554 rs776686044	141	E>K		No	ClinGen ExAC TOPMed gnomAD
CA4726555 rs762003163	142	S>A		No	ClinGen ExAC gnomAD
CA4726556 rs769715619	142	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1563277175 CA371047503 COSM318595	143	W>C	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1347110962 CA371047530	147	S>R		No	ClinGen gnomAD
CA4726558 rs759404870	149	T>S		No	ClinGen ExAC gnomAD
rs1487585042 CA371047547	150	N>I		No	ClinGen TOPMed gnomAD
rs1487585042 CA371047546	150	N>S		No	ClinGen TOPMed gnomAD
CA175911694 rs267601921	154	Q>*		No	ClinGen Ensembl
CA4726560 rs752549936	154	Q>R		No	ClinGen ExAC gnomAD
rs763844705 CA4726562	159	R>Q		No	ClinGen ExAC gnomAD
rs760455234 CA4726561	159	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1211015184 CA371047626	160	L>V		No	ClinGen TOPMed
TCGA novel	161	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1243368199 CA371047646	162	V>F		No	ClinGen TOPMed gnomAD
rs1243368199 COSM1457066 CA371047643	162	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA4726567 rs758917144	165	G>A		No	ClinGen ExAC gnomAD
CA175911715 rs971058322	168	V>M		No	ClinGen Ensembl
CA175911721 rs1002596164 COSM1099840	171	R>W	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA371047792 rs1319325108	173	C>G		No	ClinGen TOPMed
CA371047833 rs1410370816	175	L>P		No	ClinGen gnomAD
rs1164125493 CA371047862	177	P>L		No	ClinGen gnomAD
CA4726572 rs781500138	179	R>G		No	ClinGen ExAC gnomAD
TCGA novel	180	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746883357 CA4726597	180	I>M		No	ClinGen ExAC gnomAD
CA371048230 rs1213591396	181	A>T		No	ClinGen gnomAD
rs1211834933 CA371048259	185	T>I		No	ClinGen gnomAD
CA4726599 rs776233376	189	L>P		No	ClinGen ExAC gnomAD
rs145222803 CA4726601	194	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA371048330 rs1180479690	197	V>A		No	ClinGen TOPMed gnomAD
rs747762111 CA175911926	197	V>M		No	ClinGen Ensembl
CA4726602 rs772976570	200	L>V		No	ClinGen ExAC gnomAD
rs762573991 CA4726603	203	G>W		No	ClinGen ExAC gnomAD
rs767946041 CA4726624	204	R>S		No	ClinGen ExAC TOPMed gnomAD
CA371048407 rs1459861767	207	E>*		No	ClinGen gnomAD
rs1166999453 CA371048410	207	E>V		No	ClinGen gnomAD
rs1394945153 CA371048422	209	M>V		No	ClinGen gnomAD
CA371048451 rs1178099968	212	H>R		No	ClinGen TOPMed
rs144971917 CA4726627	213	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs757415755 CA4726629	219	R>Q		No	ClinGen ExAC gnomAD
rs1275110506 CA371048500	219	R>W		No	ClinGen TOPMed
rs750536765 CA4726631	222	V>M		No	ClinGen ExAC TOPMed gnomAD
rs758473461 CA4726632 COSM1099841	223	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA371048524 rs1195551029	223	R>Q		No	ClinGen gnomAD
CA371048529 rs1248819678	224	A>T		No	ClinGen TOPMed gnomAD
CA4726633 rs181217466	224	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1327294593 CA371048539	226	T>A		No	ClinGen TOPMed
CA371048569 rs1167021342	229	I>F		No	ClinGen gnomAD
CA4726636 rs777651640	230	T>A		No	ClinGen ExAC TOPMed gnomAD
CA371048584 rs1304452731	230	T>I		No	ClinGen gnomAD
CA371048603 rs1165984834	232	H>R		No	ClinGen gnomAD
rs377666224 CA4726637	232	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	234	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	236	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371048676 rs1293970965	238	P>A		No	ClinGen gnomAD
rs757092018 CA4726656	238	P>R		No	ClinGen ExAC gnomAD
CA371048679 rs1359375938	239	R>G		No	ClinGen TOPMed
CA371048693 rs1563278173	240	N>K		No	ClinGen Ensembl
rs1563278170 CA371048690	240	N>S		No	ClinGen Ensembl
rs778456881 CA4726657	241	G>C		No	ClinGen ExAC TOPMed gnomAD
rs1041454554 CA175912488	244	C>Y		No	ClinGen TOPMed
CA4726658 rs745496588	246	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1311657925 CA371048773	248	H>R		No	ClinGen TOPMed
CA371048784 rs1212555952	249	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4726661 rs746510734 COSM1099843	251	P>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA4726660 rs775009661	251	P>T		No	ClinGen ExAC gnomAD
rs1428923387 CA371048801	252	I>V		No	ClinGen gnomAD
CA4726665 rs765596568	260	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs143037095 CA4726667	262	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA4726666 rs773310525	262	Y>D		No	ClinGen ExAC gnomAD
rs143037095 CA371048937	262	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	264	A>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1329229940 CA371049532	267	G>A		No	ClinGen gnomAD
rs1477735109 CA371049591	271	G>R		No	ClinGen TOPMed
CA371049609 rs1336702973	272	G>E		No	ClinGen gnomAD
CA4726693 rs765075072	274	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA371049670 rs1480459126	277	I>F		No	ClinGen gnomAD
rs765318607 CA175912718	280	A>V		No	ClinGen Ensembl
rs750301619 CA4726694	282	V>L		No	ClinGen ExAC gnomAD
rs368929609 CA4726695	284	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1187881943 CA371049808	286	P>R		No	ClinGen gnomAD
rs751164953 CA175912730	288	V>F		No	ClinGen ExAC TOPMed gnomAD
rs751164953 CA4726697	288	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1563278482 CA371049867	289	W>C		No	ClinGen Ensembl
CA175912738 rs371903817	291	E>D		No	ClinGen ESP TOPMed
rs754488446 CA4726698	291	E>K		No	ClinGen ExAC gnomAD
CA371049893 rs1460211123	292	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1299459008 CA371049897	292	R>H		No	ClinGen TOPMed gnomAD
rs1299459008 CA371049895	292	R>L		No	ClinGen TOPMed gnomAD
CA371049909 rs1413571473	293	S>L		No	ClinGen gnomAD
rs1427920537 CA371049923	294	E>D		No	ClinGen gnomAD
rs1416576424 CA371049928	295	V>L		No	ClinGen TOPMed
rs1338577920 CA371049947	296	K>N		No	ClinGen TOPMed
rs770397529 CA4726701	298	R>C		No	ClinGen ExAC gnomAD
CA371049966 rs1228798384	298	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1419161534 CA371050007	303	K>E		No	ClinGen Ensembl
rs1190951657 CA371050070	306	T>A		No	ClinGen gnomAD
CA4726724 rs749715016	307	E>K		No	ClinGen ExAC gnomAD
rs771335510 CA4726725	308	H>P		No	ClinGen ExAC gnomAD
rs78295909 CA4726726	308	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs746223695 CA4726727	309	V>L		No	ClinGen ExAC gnomAD
rs772493321 CA4726728	311	D>E		No	ClinGen ExAC gnomAD
CA371050105 rs1238673251	311	D>G		No	ClinGen TOPMed
rs72638927 CA4726730	312	K>I		No	ClinGen ExAC gnomAD
rs1343323122 CA371050129	314	K>N		No	ClinGen TOPMed gnomAD
rs768569811 CA4726731	319	I>V		No	ClinGen ExAC gnomAD
CA371050163 rs1220771897	320	F>V		No	ClinGen TOPMed
TCGA novel	334	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4726747 rs747159361	338	S>G		No	ClinGen ExAC gnomAD
CA4726748 rs374853413	341	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1585674873 CA371050395	346	Y>S		No	ClinGen Ensembl
CA4726750 rs374624501	349	A>G		No	ClinGen ESP ExAC gnomAD
rs1212167469 CA371050435	350	I>M		No	ClinGen gnomAD
rs1167582807 CA371050893	358	D>N		No	ClinGen gnomAD
rs1431828528 CA371050965	364	S>N		No	ClinGen TOPMed gnomAD
rs1423307177 CA371050999	367	G>R		No	ClinGen TOPMed
CA4726771 rs774300566	368	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1467841263 CA371051038	370	T>A		No	ClinGen TOPMed
rs777945418 CA4726772	374	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1227098443 CA371051086	375	M>L		No	ClinGen gnomAD
rs771864075 CA4726773 COSM1099845 CA371051106	376	M>I	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA371051110 rs1585678238	377	T>P		No	ClinGen Ensembl
rs1228661101 CA371051123	378	S>N		No	ClinGen gnomAD
rs1585678251 CA371051132	379	W>G		No	ClinGen Ensembl
CA371051156 rs1279068173	380	A>V		No	ClinGen gnomAD
CA371051161 rs1563280779	381	I>V		No	ClinGen Ensembl
CA4726774 rs775210430	382	V>A		No	ClinGen ExAC gnomAD
rs776328407 CA4726778	385	V>L		No	ClinGen ExAC TOPMed gnomAD
CA4726777 rs776328407	385	V>M		No	ClinGen ExAC TOPMed gnomAD
CA371051221 rs1585678287	387	Y>S		No	ClinGen Ensembl
rs1313649685 CA371051242	389	P>S		No	ClinGen TOPMed
CA175915414 rs764802073	390	P>H		No	ClinGen ExAC TOPMed gnomAD
CA4726779 rs764802073	390	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1300781541 CA371051247	390	P>S		No	ClinGen TOPMed
CA175915420 rs946151758	391	M>K		No	ClinGen TOPMed gnomAD
CA4726780 rs750971120	391	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1384862026 CA371051272	392	T>S		No	ClinGen TOPMed
rs776455733 CA4726794	395	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4726795 rs761493151	397	E>G		No	ClinGen ExAC gnomAD
rs1225680309 CA371051828	397	E>K		No	ClinGen TOPMed
rs772923260 CA4726797	398	D>G		No	ClinGen ExAC gnomAD
rs1314022876 CA371051891	401	Q>R		No	ClinGen TOPMed
TCGA novel	403	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA175922710 rs878930531	404	N>Y		No	ClinGen Ensembl
rs1312511288 CA371052178	418	D>G		No	ClinGen TOPMed
TCGA novel	418	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4726804 rs772946390	420	L>Q		No	ClinGen ExAC
rs1254042510 CA371052305	423	G>R		No	ClinGen gnomAD
rs375253090 CA4726817	428	E>K		No	ClinGen ESP ExAC gnomAD
rs748770051 CA371052350	429	K>N		No	ClinGen ExAC TOPMed gnomAD
CA371052348 rs1165076531	429	K>R		No	ClinGen gnomAD
CA4726820 rs143006137	433	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4726819 rs143006137	433	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4726822 rs767995915	436	E>K		No	ClinGen ExAC gnomAD
rs1300950410 CA371052409	438	Q>K		No	ClinGen gnomAD
CA371052458 rs1294548862	444	K>R		No	ClinGen gnomAD
CA371052472 rs1341781737	446	I>V		No	ClinGen gnomAD
CA175923500 rs963843628	447	V>L		No	ClinGen gnomAD
rs1483387146 CA371052486	448	G>E		No	ClinGen gnomAD
CA4726824 rs760999237	449	N>S		No	ClinGen ExAC gnomAD
rs1585679975 CA371052502	450	H>Q		No	ClinGen Ensembl
CA371052505 rs1236183522	451	K>E		No	ClinGen gnomAD
rs1585679996 CA371052515	452	D>A		No	ClinGen Ensembl
rs1484505834 CA371052518	452	D>E		No	ClinGen gnomAD
rs1585679983 CA371052514	452	D>Y		No	ClinGen Ensembl
CA4726825 rs764351730	453	R>G		No	ClinGen ExAC
CA175923508 rs971551778	454	S>I		No	ClinGen TOPMed
rs750624557 CA175923510	455	R>C		No	ClinGen Ensembl
rs1419230409 CA371052535	455	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD

No associated diseases with Q86UL3

2 regional properties for Q86UL3

Type	Name	Position	InterPro Accession
domain	Phospholipid/glycerol acyltransferase	229 - 353	IPR002123
domain	Lysophosphatidylcholine acyltransferase LPCAT1-like	218 - 427	IPR045252

Functions

		Description
EC Number	2.3.1.15	Transferring groups other than amino-acyl groups
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

3 GO annotations of molecular function

Name	Definition
1-acylglycerol-3-phosphate O-acyltransferase activity	Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.
glycerol-3-phosphate O-acyltransferase activity	Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.
sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity	Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate.

11 GO annotations of biological process

Name	Definition
acyl-CoA metabolic process	The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
CDP-diacylglycerol biosynthetic process	The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.
diacylglycerol metabolic process	The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
fatty acid metabolic process	The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
glandular epithelial cell maturation	The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.
lactation	The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
lipid biosynthetic process	The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
phosphatidic acid biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
phosphatidylcholine biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
regulation of multicellular organism growth	Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
triglyceride biosynthetic process	The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A3FPG8	GPAT4	Glycerol-3-phosphate acyltransferase 4	Bos taurus (Bovine)	PR
Q5ZLL8	GPAT3	Glycerol-3-phosphate acyltransferase 3	Gallus gallus (Chicken)	PR
Q9Y679	AUP1	Lipid droplet-regulating VLDL assembly factor AUP1	Homo sapiens (Human)	PR
Q8NF37	LPCAT1	Lysophosphatidylcholine acyltransferase 1	Homo sapiens (Human)	PR
Q8C0N2	Gpat3	Glycerol-3-phosphate acyltransferase 3	Mus musculus (Mouse)	PR
Q8K2C8	Gpat4	Glycerol-3-phosphate acyltransferase 4	Mus musculus (Mouse)	PR
Q8S8S2	LPEAT2	Lysophospholipid acyltransferase LPEAT2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6PBN5	aup1	Lipid droplet-regulating VLDL assembly factor AUP1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
A3KGT9	agpat9l	Glycerol-3-phosphate acyltransferase 3-like	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MFLLLPFDSL	IVNLLGISLT	VLFTLLLVFI	IVPAIFGVSF	GIRKLYMKSL	LKIFAWATLR
70	80	90	100	110	120
MERGAKEKNH	QLYKPYTNGI	IAKDPTSLEE	EIKEIRRSGS	SKALDNTPEF	ELSDIFYFCR
130	140	150	160	170	180
KGMETIMDDE	VTKRFSAEEL	ESWNLLSRTN	YNFQYISLRL	TVLWGLGVLI	RYCFLLPLRI
190	200	210	220	230	240
ALAFTGISLL	VVGTTVVGYL	PNGRFKEFMS	KHVHLMCYRI	CVRALTAIIT	YHDRENRPRN
250	260	270	280	290	300
GGICVANHTS	PIDVIILASD	GYYAMVGQVH	GGLMGVIQRA	MVKACPHVWF	ERSEVKDRHL
310	320	330	340	350	360
VAKRLTEHVQ	DKSKLPILIF	PEGTCINNTS	VMMFKKGSFE	IGATVYPVAI	KYDPQFGDAF
370	380	390	400	410	420
WNSSKYGMVT	YLLRMMTSWA	IVCSVWYLPP	MTREADEDAV	QFANRVKSAI	ARQGGLVDLL
430	440	450
WDGGLKREKV	KDTFKEEQQK	LYSKMIVGNH	KDRSRS