AiPD: Autoinhibited Protein Database

Q86U86

Gene name	PBRM1 (BAF180, PB1)
Protein name	Protein polybromo-1
Names	hPB1, BRG1-associated factor 180, BAF180, Polybromo-1D
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55193
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-57 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

31 structures for Q86U86

Entry ID	Method	Resolution	Chain	Position	Source
2KTB	NMR	-	B	174-293	PDB
3G0J	X-ray	178 A	A/B	645-766	PDB
3HMF	X-ray	163 A	A	178-291	PDB
3IU5	X-ray	163 A	A	43-154	PDB
3IU6	X-ray	179 A	A	773-914	PDB
3K2J	X-ray	220 A	A/B	388-494	PDB
3LJW	X-ray	150 A	A/B	174-293	PDB
3MB4	X-ray	166 A	A/B	645-766	PDB
3TLP	X-ray	213 A	A/B	496-637	PDB
4Q0N	X-ray	178 A	A/B/C/D/E/F/G/H	645-766	PDB
4Q0O	X-ray	183 A	A	645-766	PDB
4Y03	X-ray	194 A	A/B	645-766	PDB
5E7D	X-ray	187 A	A/B/C/D	645-766	PDB
5FH6	X-ray	230 A	A/B/C/D	645-766	PDB
5FH7	X-ray	147 A	A/B	645-766	PDB
5FH8	X-ray	155 A	A/B/C/D	645-766	PDB
5HRV	X-ray	170 A	A	645-766	PDB
5HRW	X-ray	180 A	A/B	645-766	PDB
5HRX	X-ray	173 A	A/B	645-766	PDB
5II1	X-ray	202 A	A/B	645-766	PDB
5II2	X-ray	210 A	A/B	645-766	PDB
5IID	X-ray	240 A	A/B	645-766	PDB
6OXB	X-ray	186 A	A/B/C/D/E/F	934-1105	PDB
6ZN6	X-ray	202 A	A/B	178-291	PDB
6ZNV	X-ray	114 A	A	178-291	PDB
6ZS3	X-ray	167 A	A/B	645-766	PDB
6ZS4	X-ray	200 A	A	645-766	PDB
7VDV	EM	340 A	a	631-1689	PDB
7Y8R	EM	440 A	U	1-1689	PDB
8FTA	X-ray	178 A	A	178-291	PDB
AF-Q86U86-F1	Predicted				AlphaFoldDB

1098 variants for Q86U86

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV000203297 rs864321679	1333	D>missing	Clear cell carcinoma of kidney [ClinVar]	Yes	ClinVar dbSNP
CA353125288 rs1289736713	5	R>K		No	ClinGen TOPMed gnomAD
TCGA novel	6	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	7	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1169692229 CA353125154	8	A>T		No	ClinGen TOPMed
rs757435999 CA2444923	14	S>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	15	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764436452 CA2444921	17	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA353124706 rs1430148210	18	D>G		No	ClinGen gnomAD
CA353124651 rs1419786453	21	D>V		No	ClinGen gnomAD
CA2444920 rs762937964	22	G>E		No	ClinGen ExAC gnomAD
CA2444919 rs775590005	24	H>R		No	ClinGen ExAC gnomAD
CA353124547 rs1462165446	26	V>L		No	ClinGen TOPMed gnomAD
rs776368520 CA2444916	27	S>L		No	ClinGen ExAC
rs1162990450 CA353124459	29	P>L		No	ClinGen Ensembl
rs1296667861 CA353124464	29	P>S		No	ClinGen TOPMed
rs1362922218 CA353124394	32	S>I		No	ClinGen TOPMed
CA353124387 COSM191333 rs1309671151	32	S>R	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1296531217 CA353124383	33	R>G		No	ClinGen TOPMed gnomAD
rs1353693878 CA353124243	36	R>K		No	ClinGen TOPMed gnomAD
TCGA novel	38	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs529388126 CA2444913	40	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1317265743 CA353124129	41	L>I		No	ClinGen TOPMed gnomAD
rs1453215498 CA353124110	41	L>R		No	ClinGen gnomAD
CA353124096 rs1219845160	42	P>S		No	ClinGen gnomAD
rs771820105 CA2444912	43	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1578377767 CA353124056	44	V>A		No	ClinGen Ensembl
TCGA novel	44	V>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747627905 CA2444911	44	V>I		No	ClinGen ExAC gnomAD
rs1247840974 CA353123982	46	P>L		No	ClinGen TOPMed
CA74775522 rs866121544	48	A>V		No	ClinGen gnomAD
VAR_064653	49	V>L	found in a lung cancer cell line [UniProt]	No	UniProt
rs542945393 CA2444890	49	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	50	C>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748868709 CA2444889	50	C>S		No	ClinGen ExAC gnomAD
CA353123055 rs934149529	52	E>D		No	ClinGen TOPMed gnomAD
CA353123045 rs1223568786	53	L>I		No	ClinGen gnomAD
CA353123034 rs1353015727	53	L>R		No	ClinGen gnomAD
CA74775515 VAR_064654 rs923060956	56	T>A	found in a brain cancer cell line [UniProt]	No	ClinGen UniProt TOPMed dbSNP
CA353122958 rs923060956	56	T>P		No	ClinGen TOPMed
VAR_064655	57	I>del	found in a case of clear cell renal carcinoma; somatic mutation [UniProt]	No	UniProt
rs1402616012 CA353122896	58	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	59	D>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353122840 rs1241024217	60	Y>C		No	ClinGen gnomAD
rs373517762 CA2444888	61	K>E		No	ClinGen ESP ExAC gnomAD
CA2444887 rs771509389	64	Q>R		No	ClinGen ExAC gnomAD
rs368888772 CA2444886 VAR_064656	66	R>G	found in a colon cancer cell line [UniProt]	No	ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD
rs758577145 CA2444884	67	L>P		No	ClinGen ExAC gnomAD
TCGA novel	69	C>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1399041381 CA353122590	71	L>P		No	ClinGen gnomAD
CA353122557 rs1382054424	73	I>T		No	ClinGen gnomAD
TCGA novel	74	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755035966 CA2444881	78	R>L		No	ClinGen ExAC TOPMed gnomAD
CA2444882 rs755035966	78	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA353119979 rs1195663483	80	N>S		No	ClinGen gnomAD
rs1201615673 CA542913929	84	Y>*		No	ClinGen gnomAD
rs1242639227 CA353119917	84	Y>N		No	ClinGen gnomAD
CA353119885 rs1263745037	86	E>K		No	ClinGen gnomAD
CA2444863 rs779102269	89	S>Y		No	ClinGen ExAC gnomAD
VAR_064657	90	Q>E	found in a bladder cancer cell line [UniProt]	No	UniProt
CA353119772 rs1372633093	95	M>I		No	ClinGen TOPMed
CA74769108 rs74646140	98	Q>K		No	ClinGen Ensembl
rs1227735355 CA353119682	100	K>R		No	ClinGen gnomAD
rs1451023142 CA353119543	111	L>S		No	ClinGen TOPMed gnomAD
TCGA novel	112	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs867702624 CA74769089	114	A>D		No	ClinGen Ensembl
TCGA novel	115	D>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353119432 rs1469677552	116	F>L		No	ClinGen TOPMed
TCGA novel	116	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	120	F>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353119351 rs1468575151	121	N>S		No	ClinGen TOPMed
TCGA novel	122	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	126	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444857 rs767623683	127	Y>F		No	ClinGen ExAC gnomAD
CA2444858 rs750391682	127	Y>H		No	ClinGen ExAC gnomAD
CA2444836 rs746006175	130	D>V		No	ClinGen ExAC TOPMed gnomAD
CA2444834 rs757308937	132	P>L		No	ClinGen ExAC gnomAD
CA2444835 rs139891456	132	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	134	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	134	Y>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	136	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA161386 rs587778592 RCV000121777	137	A>S		No	ClinGen ClinVar Ensembl dbSNP
TCGA novel	142	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1345333291 CA353116191	143	L>S		No	ClinGen gnomAD
VAR_064658	144	Y>F	found in a malignant melanoma cell line [UniProt]	No	UniProt
CA2444831 rs757924256	146	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2444829 rs764853847	151	F>L		No	ClinGen ExAC gnomAD
CA2444828 rs759080524	152	V>I		No	ClinGen ExAC gnomAD
CA353115950 rs1355959617	155	G>R		No	ClinGen TOPMed
rs762326260 CA2444825	159	D>E		No	ClinGen ExAC TOPMed gnomAD
VAR_064659	160	E>A	found in a malignant melanoma cell line [UniProt]	No	UniProt
rs1327678669 CA353115828	160	E>G		No	ClinGen TOPMed
CA2444824 rs774655494	160	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA353115814 rs1426978823	161	D>G		No	ClinGen TOPMed gnomAD
CA2444823 rs769010138	161	D>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs763287444 CA2444822	163	D>G		No	ClinGen ExAC gnomAD
CA353115764 rs1213027214	164	E>G		No	ClinGen gnomAD
CA2444821 rs775778967	164	E>K		No	ClinGen ExAC gnomAD
rs745942186 CA2444818	166	G>R		No	ClinGen ExAC TOPMed gnomAD
CA2444817 rs781444225	166	G>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	167	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA74766472 rs920146921	168	D>E		No	ClinGen TOPMed
rs1281777672 CA353115713	168	D>N		No	ClinGen gnomAD
rs144003080 CA2444816	169	N>S		No	ClinGen ESP ExAC gnomAD
CA2444815 rs746949395	171	G>C		No	ClinGen ExAC gnomAD
CA2444813 rs758198630	171	G>D		No	ClinGen ExAC TOPMed gnomAD
CA2444814 rs758198630	171	G>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	172	T>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353115614 rs1261727399	175	E>K		No	ClinGen TOPMed
CA2444812 rs752499912	176	G>A		No	ClinGen ExAC gnomAD
CA353115601 rs1560914802	176	G>R		No	ClinGen Ensembl
CA353142924 rs1182431123	178	S>F		No	ClinGen gnomAD
CA2444792 rs754615251	179	P>L		No	ClinGen ExAC gnomAD
rs754615251 CA2444791	179	P>R		No	ClinGen ExAC gnomAD
rs779478603 CA2444789	181	Y>C		No	ClinGen ExAC TOPMed
CA353142777 rs1239653223	184	E>G		No	ClinGen gnomAD
CA353142762 rs1185988525	185	I>V		No	ClinGen gnomAD
rs542464402 CA2444786	187	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	188	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353142561 rs1275698120	192	A>G		No	ClinGen gnomAD
CA2444785 rs763396689	193	I>V		No	ClinGen ExAC TOPMed gnomAD
CA2444784 rs376949564	194	V>I		No	ClinGen ESP ExAC gnomAD
rs376949564 CA74791735	194	V>L		No	ClinGen ESP ExAC gnomAD
CA353142459 rs1317016863	196	A>P		No	ClinGen TOPMed gnomAD
CA74791730 rs1011877149	198	N>H		No	ClinGen Ensembl
rs1396571484 CA353142404	198	N>S		No	ClinGen TOPMed gnomAD
VAR_064660 rs765525545 CA2444783	202	R>C	Variant assessed as Somatic; 0.0 impact. found in a endometrial cancer cell line [NCI-TCGA, UniProt]	No	ClinGen UniProt ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs759776302 CA353142315	202	R>H		No	ClinGen ExAC gnomAD
rs759776302 CA2444782	202	R>L		No	ClinGen ExAC gnomAD
CA2444779 rs760805870	204	I>T		No	ClinGen ExAC gnomAD
rs938439524 CA74791681	205	S>G		No	ClinGen TOPMed gnomAD
CA2444778 rs773213985	205	S>T		No	ClinGen ExAC gnomAD
rs1027804016 CA74791680	206	E>A		No	ClinGen TOPMed
VAR_064661 CA353142269 rs1359676390	206	E>K	Variant assessed as Somatic; impact. found in hematopoietic and lymphoid cancer cell lines [NCI-TCGA, UniProt]	No	ClinGen UniProt NCI-TCGA dbSNP gnomAD
CA353142250 rs1207845767	207	L>I		No	ClinGen TOPMed
TCGA novel	209	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1560868667 CA353142193	210	K>E		No	ClinGen Ensembl
TCGA novel	212	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768346787 CA2444774	215	V>M		No	ClinGen ExAC TOPMed gnomAD
CA353139731 rs1452505370	221	Y>H		No	ClinGen gnomAD
CA2444761 rs761000540	222	A>V		No	ClinGen ExAC TOPMed
TCGA novel	223	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_064662	226	E>G	found in hematopoietic and lymphoid cancer cell lines [UniProt]	No	UniProt
CA353139534 rs1405242902	227	P>A		No	ClinGen gnomAD
TCGA novel	227	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM2854207 rs201022657 COSM2854209 CA2444760 COSM2854208 VAR_064663	228	I>V	skin found in a breast cancer cell line [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
CA2444759 rs767495974	229	D>N		No	ClinGen ExAC gnomAD
VAR_064664	232	T>P	found in a case of clear cell renal carcinoma; somatic mutation [UniProt]	No	UniProt
VAR_064665	233	I>T	found in a renal carcinoma cell line [UniProt]	No	UniProt
rs374259925 CA74788563	233	I>V		No	ClinGen ESP TOPMed
CA2444758 rs761749676	234	A>S		No	ClinGen ExAC TOPMed gnomAD
CA2444757 rs559073890	236	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA353137827 rs1226275680	239	N>D		No	ClinGen TOPMed gnomAD
CA2444738 rs762910140	241	S>G		No	ClinGen ExAC gnomAD
CA353137681 rs1315030011	243	K>E		No	ClinGen gnomAD
CA2444737 rs775203392	243	K>R		No	ClinGen ExAC gnomAD
CA74787081 rs930104150	245	I>V		No	ClinGen TOPMed
RCV000121778 CA161388 rs587778593	246	H>N		No	ClinGen ClinVar ExAC dbSNP gnomAD
CA353137551 rs1560759017	246	H>R		No	ClinGen Ensembl
CA353137530 rs1577530035	247	A>T		No	ClinGen Ensembl
TCGA novel	248	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353137377 rs1171540806	249	A>V		No	ClinGen TOPMed
CA353137351 rs1366553381	250	K>R		No	ClinGen TOPMed gnomAD
COSM1663346 rs1468547899 CA353137266 COSM1663347 COSM1663348	252	I>T	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1336699347 CA353137269	252	I>V		No	ClinGen gnomAD
VAR_064666 rs776146971 CA2444735	256	A>T	Variant assessed as Somatic; 4.622e-05 impact. found in an ovary carcinoma cell line [NCI-TCGA, UniProt]	No	ClinGen UniProt ExAC NCI-TCGA TOPMed dbSNP gnomAD
TCGA novel	258	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	262	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	262	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353136782 rs1190586070	264	E>G		No	ClinGen gnomAD
CA74787066 rs963262810	268	Q>H		No	ClinGen TOPMed
TCGA novel	271	K>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353135270 rs1473745423	272	D>H		No	ClinGen gnomAD
TCGA novel	273	A>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353135051 rs1560714275	278	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA353135029 rs1185098475	279	I>K		No	ClinGen gnomAD
TCGA novel	279	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1185098475 CA353135022	279	I>T		No	ClinGen gnomAD
rs369874660 CA2444710	279	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs771618422	279	I>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA2444708 rs772781719 COSM1663344 COSM1663343 COSM1663345	281	Y>F	kidney [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA353134878 rs1456829704	283	K>E		No	ClinGen TOPMed
TCGA novel	283	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353134859 rs1205460631	284	K>Q		No	ClinGen gnomAD
CA353134827 rs1165577622	285	A>V		No	ClinGen TOPMed
CA353134823 rs1490033079	286	E>K		No	ClinGen gnomAD
CA353134782 rs1288968634	287	I>T		No	ClinGen TOPMed gnomAD
rs370211100 CA2444706	288	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs780700287 CA2444705	289	H>R		No	ClinGen ExAC gnomAD
TCGA novel	291	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs558495798 CA74785620	291	E>K		No	ClinGen 1000Genomes
TCGA novel	292	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770383330 CA2444704	293	A>V		No	ClinGen ExAC gnomAD
rs995859396 CA74785617	296	S>T		No	ClinGen gnomAD
CA74785614 rs185448951	298	R>Q		No	ClinGen 1000Genomes gnomAD
CA353134313 rs1310042762	299	M>I		No	ClinGen gnomAD
rs1321002922 CA353133714	304	N>S		No	ClinGen TOPMed gnomAD
rs1456923730 CA353133686	306	A>G		No	ClinGen TOPMed
rs1271218463 CA353133634	308	A>D		No	ClinGen gnomAD
rs1463926262 CA353133646	308	A>P		No	ClinGen TOPMed gnomAD
CA2444686 rs774022977	309	R>K		No	ClinGen ExAC
CA353133568 rs1560695240	311	T>A		No	ClinGen Ensembl
CA353133545 rs1346930110	311	T>R		No	ClinGen TOPMed
CA2444685 rs770161934	312	G>D		No	ClinGen ExAC gnomAD
CA2444684 rs746391738	313	P>A		No	ClinGen ExAC gnomAD
rs746633005 CA74784974	315	H>Q		No	ClinGen ExAC gnomAD
rs1342451247 CA353133421	315	H>Y		No	ClinGen gnomAD
CA353133356 rs1276712891	317	K>E		No	ClinGen gnomAD
CA74784970 rs959810153	318	G>D		No	ClinGen Ensembl
rs1360187985 CA353133141	324	R>I		No	ClinGen gnomAD
CA353133101 rs1577385768	325	N>H		No	ClinGen Ensembl
TCGA novel	325	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1577385704 CA353133044	326	P>L		No	ClinGen Ensembl
rs1295615404 CA353133001	328	S>N		No	ClinGen gnomAD
rs1458757274 CA353132980	329	K>Q		No	ClinGen TOPMed gnomAD
rs1284306673 CA353132929	330	Y>H		No	ClinGen TOPMed
rs747444363 CA2444681	331	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs374515597 CA2444679	332	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA353132887 rs374515597	332	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA2444678 rs748174546	332	R>H		No	ClinGen ExAC gnomAD
TCGA novel	333	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA161376 RCV000121772 rs547790173	333	N>S		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA353132018 rs1560675648	333	N>Y		No	ClinGen Ensembl
rs1245408239 CA353131807	339	G>E		No	ClinGen gnomAD
VAR_064667 rs200106731 CA2444636	340	G>A	found in a malignant melanoma cell line [UniProt]	No	ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD
CA353131781 rs200106731	340	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA2444637 rs751210666	340	G>S		No	ClinGen ExAC TOPMed gnomAD
CA74784251 rs764156634	341	R>C		No	ClinGen TOPMed gnomAD
rs373247018 CA2444635	341	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs766863761 CA2444633	344	A>E		No	ClinGen ExAC TOPMed gnomAD
rs1301977768 CA353131530	345	I>T		No	ClinGen gnomAD
rs761199482 CA2444632	345	I>V		No	ClinGen ExAC gnomAD
TCGA novel	347	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353131489 rs1239938907	347	M>V		No	ClinGen TOPMed
CA353131420 rs1455995188	348	A>V		No	ClinGen gnomAD
rs773495785 CA2444631	349	L>F		No	ClinGen ExAC gnomAD
rs369012659 CA2444630	350	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs774627745 CA2444628	351	Y>C		No	ClinGen ExAC TOPMed
CA353131338 rs1407715900	352	G>V		No	ClinGen gnomAD
rs147057026 CA74784199	355	S>N		No	ClinGen ESP
CA2444626 rs749364981	357	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1252895125 CA353131170	358	D>G		No	ClinGen gnomAD
TCGA novel	358	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1487575653 CA353131138	359	A>T		No	ClinGen gnomAD
rs1174970365 CA353131111	360	A>T		No	ClinGen TOPMed
TCGA novel	360	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1267092200 CA353131094	361	L>V		No	ClinGen gnomAD
rs1307761878 CA353128433	363	A>V		No	ClinGen TOPMed
rs147499494 CA2444600	365	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2444601 rs147499494	365	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2444599 rs757998686	365	R>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	365	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA161378 rs373477703 RCV000121773	366	Y>C		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA2444598 rs778591127	366	Y>H		No	ClinGen ExAC gnomAD
rs778591127 CA2444597	366	Y>N		No	ClinGen ExAC gnomAD
rs373477703 CA2444596	366	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA353128210 rs1246059681	374	E>G		No	ClinGen gnomAD
CA353128156 rs1190464445	377	T>I		No	ClinGen gnomAD
CA353128168 rs1354426625	377	T>P		No	ClinGen TOPMed
CA74779047 rs896608828	378	S>A		No	ClinGen TOPMed gnomAD
rs767987709 CA2444595	381	D>G		No	ClinGen ExAC gnomAD
TCGA novel	382	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751885636 CA2444593	383	S>L		No	ClinGen ExAC gnomAD
CA74779025 rs913417875	384	N>H		No	ClinGen gnomAD
CA353128013 rs1176334509	385	P>R		No	ClinGen TOPMed gnomAD
rs764381947 CA2444592	386	F>S		No	ClinGen ExAC gnomAD
TCGA novel	387	Y>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs866423710 CA74779015	388	Q>H		No	ClinGen Ensembl
CA74779009 rs935520845	389	L>I		No	ClinGen TOPMed
CA2444591 rs763433177	390	Y>F		No	ClinGen ExAC gnomAD
rs775851420 CA2444590	392	T>R		No	ClinGen ExAC gnomAD
CA353127825 rs1440257006	396	C>Y		No	ClinGen TOPMed
CA2444588 rs759670972	397	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1394725381 CA353127813	397	R>W		No	ClinGen gnomAD
CA2444586 rs770955783	398	N>T		No	ClinGen ExAC gnomAD
rs746922143 CA2444585	400	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA2444583 rs140652006	406	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA353127666 rs1449987855	406	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353127651 rs748039131	407	P>A		No	ClinGen ExAC TOPMed gnomAD
CA353127621 rs778505553	407	P>L		No	ClinGen ExAC gnomAD
CA2444581 rs778505553	407	P>R		No	ClinGen ExAC gnomAD
rs748039131 CA74778926	407	P>S		No	ClinGen ExAC TOPMed gnomAD
rs748039131 CA2444582	407	P>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	409	Y>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1256365201 CA353127569	410	H>R		No	ClinGen gnomAD
rs1194904129 CA353127534	412	P>S		No	ClinGen gnomAD
TCGA novel	417	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444578 rs779570305	417	Y>N		No	ClinGen ExAC gnomAD
TCGA novel	417	Y>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1343496358 CA353127346	419	D>H		No	ClinGen TOPMed gnomAD
rs1343496358 CA353127348	419	D>N		No	ClinGen TOPMed gnomAD
CA2444577 rs757726623	422	Q>R		No	ClinGen ExAC gnomAD
rs1243048171 CA353127233	423	Q>L		No	ClinGen gnomAD
TCGA novel	425	K>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353127185 rs1314419859	426	M>T		No	ClinGen TOPMed
rs1266329257 CA353127130	428	I>M		No	ClinGen TOPMed
CA2444575 rs764729828	428	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	429	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1458130128 CA353127068	431	Q>R		No	ClinGen TOPMed gnomAD
rs1389898698 CA353127014	434	R>Q		No	ClinGen TOPMed gnomAD
CA353125267 rs1244486563	435	T>K		No	ClinGen gnomAD
CA353125028 rs1208471505	441	E>A		No	ClinGen gnomAD
rs745423588 CA2444557	444	T>I		No	ClinGen ExAC gnomAD
CA353124829 rs1270204507	445	L>S		No	ClinGen gnomAD
COSM1291746 CA2444556 COSM1291747 COSM1291745 rs778123731	446	D>G	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA353124746 rs1560516560	447	H>Q		No	ClinGen Ensembl
CA353124774 rs1474605653	447	H>Y		No	ClinGen TOPMed
TCGA novel	448	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353124713 rs758971781	449	E>A		No	ClinGen ExAC gnomAD
rs758971781 CA2444555	449	E>G		No	ClinGen ExAC gnomAD
CA353124716 rs1188691461	449	E>Q		No	ClinGen TOPMed
rs753073607 CA2444554	450	C>F		No	ClinGen ExAC TOPMed gnomAD
CA74775289 rs113443596	456	F>L		No	ClinGen Ensembl
CA353124410 rs1438786040	460	K>R		No	ClinGen TOPMed gnomAD
COSM3427748 COSM3427746 rs779427834 CA2444553 COSM3427747	461	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA2444552 rs755190183	461	R>H		No	ClinGen ExAC gnomAD
CA2444551 rs754097433	463	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	464	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444550 rs766686111	465	P>A		No	ClinGen ExAC gnomAD
CA74775273 rs1048538214	468	A>V		No	ClinGen Ensembl
TCGA novel	469	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353124075 rs1413539193	469	I>T		No	ClinGen gnomAD
CA2444547 rs781546758	470	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA2444546 rs375222169	471	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA2444545 rs567250482	472	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353123943 rs567250482	472	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2444544 rs768428845	473	V>I		No	ClinGen ExAC gnomAD
rs774975430 CA2444542	477	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	479	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745324755 CA2444540	479	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1348721028 CA353123676	480	M>T		No	ClinGen gnomAD
TCGA novel	484	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	485	K>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353123306 rs1302976139	486	E>D		No	ClinGen gnomAD
rs1031229949 CA74774293	486	E>K		No	ClinGen TOPMed
CA353123304 rs1465210090	487	L>F		No	ClinGen gnomAD
CA2444527 rs34704994	488	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs762715677 CA2444526	488	A>V		No	ClinGen ExAC gnomAD
rs145261114 CA2444525	489	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs964967913 CA74774252	492	D>N		No	ClinGen gnomAD
rs147488144 CA353123177	493	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353123183 rs1376740803	493	I>T		No	ClinGen gnomAD
CA353123150 rs1400672969	494	E>G		No	ClinGen TOPMed
rs371948738 CA2444522	494	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs889851563 CA74774232	496	G>E		No	ClinGen TOPMed gnomAD
CA353123124 rs1305638216	496	G>R		No	ClinGen gnomAD
TCGA novel	498	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	500	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444518 rs374799219	508	G>S		No	ClinGen ESP ExAC gnomAD
rs1011750064 CA74774201	511	K>E		No	ClinGen Ensembl
TCGA novel	514	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353119470 rs1412410494	516	K>R		No	ClinGen TOPMed
TCGA novel	517	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs148299797 CA2444492	518	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	521	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	522	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_064668	523	M>I	found in a case of clear cell renal carcinoma; somatic mutation [UniProt]	No	UniProt
CA74768406 rs769288761	525	I>M		No	ClinGen Ensembl
TCGA novel	527	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777837959 CA2444491	527	F>L		No	ClinGen ExAC gnomAD
rs201580633 CA2444490	528	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1279388550 CA353119139	529	V>D		No	ClinGen Ensembl
rs931547681 CA74768402	531	L>V		No	ClinGen TOPMed gnomAD
CA2444489 rs752670032	534	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA353118996 rs1384342266	540	R>K		No	ClinGen gnomAD
VAR_064669	540	R>S	found in a case of clear cell renal carcinoma; somatic mutation [UniProt]	No	UniProt
TCGA novel	546	F>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	546	F>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	554	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754768297 CA2444487	555	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	558	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	561	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1388326171 CA353118641	563	L>W		No	ClinGen gnomAD
TCGA novel	571	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	571	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	572	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1217543982 CA353118455	572	E>D		No	ClinGen TOPMed
TCGA novel	572	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353118440 rs1428915766	573	H>R		No	ClinGen gnomAD
rs965565832 CA74768390	576	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs554214396 CA2444484	576	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
COSM1633256 CA2444483 COSM1633257 COSM1633258 rs554214396	576	R>L	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs115997236 CA2444482	577	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	581	A>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353118212 rs1283574490	581	A>S		No	ClinGen TOPMed
CA353118175 COSM1186319 COSM1186320 rs1342068320 COSM1186321	582	G>S	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs770253796 CA2444479	584	E>D		No	ClinGen ExAC gnomAD
CA353118066 rs1476792117	585	G>E		No	ClinGen TOPMed
rs191685069 CA2444478	585	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA353118067 rs1476792117	585	G>V		No	ClinGen TOPMed
COSM446841 COSM446843 CA353118034 COSM446842 rs1192414131	586	M>I	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1394528754 CA353117989	588	E>K		No	ClinGen gnomAD
CA353117857 rs1156645577	591	K>T		No	ClinGen TOPMed gnomAD
CA353117709 rs1473718435	594	F>L		No	ClinGen gnomAD
rs771077313 CA2444476	595	R>Q		No	ClinGen ExAC gnomAD
CA2444477 rs777012889	595	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
VAR_064670	597	A>D	found in a case of clear cell renal carcinoma; somatic mutation [UniProt]	No	UniProt
CA353117650 rs1158451345	597	A>T		No	ClinGen TOPMed
TCGA novel	598	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1000859863 CA74768360	599	H>R		No	ClinGen Ensembl
CA353116817 rs1471300592	611	A>T		No	ClinGen gnomAD
rs1576783243 CA353116814	611	A>V		No	ClinGen Ensembl
rs773389113 CA2444455	613	I>M		No	ClinGen ExAC gnomAD
CA2444456 rs138925978	613	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	617	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353116609 rs1267343896	619	K>R		No	ClinGen gnomAD
VAR_064671	621	K>E	found in a case of clear cell renal carcinoma; somatic mutation [UniProt]	No	UniProt
CA2444453 rs748206914	622	R>K		No	ClinGen ExAC TOPMed gnomAD
CA2444452 rs140241012	623	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1169377404 CA353116449	624	E>K		No	ClinGen TOPMed
rs1227926175 CA353116245	629	P>L		No	ClinGen Ensembl
CA2444449 rs780198680	630	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1300222257 CA353116064	634	M>T		No	ClinGen TOPMed
rs755967526 CA2444448	634	M>V		No	ClinGen ExAC gnomAD
COSM480380 rs770885191 COSM480379 CA74767465	636	S>P	kidney [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1024011941 CA353115893	639	L>P		No	ClinGen TOPMed
rs1024011941 CA74767460	639	L>R		No	ClinGen TOPMed
TCGA novel	641	L>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444446 rs780848542	641	L>P		No	ClinGen ExAC TOPMed gnomAD
CA353114215 rs1455942323	643	R>G		No	ClinGen gnomAD
CA353114174 rs1188313069	646	G>D		No	ClinGen TOPMed gnomAD
CA353114172 rs1188313069	646	G>V		No	ClinGen TOPMed gnomAD
CA353114119 rs1279606037	650	K>E		No	ClinGen gnomAD
CA2444425 rs199992446	652	S>A		No	ClinGen ExAC TOPMed gnomAD
rs1278253484 CA353114013	655	M>T		No	ClinGen gnomAD
rs1441864184 CA353114020	655	M>V		No	ClinGen gnomAD
rs1348496356 CA353113956	658	M>I		No	ClinGen gnomAD
rs142078067 CA2444424	658	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs925277999 CA74764743	660	Q>E		No	ClinGen Ensembl
TCGA novel	660	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_064672	661	K>N	found in a case of clear cell renal carcinoma; somatic mutation [UniProt]	No	UniProt
CA353113887 rs1412847071	663	N>D		No	ClinGen TOPMed
TCGA novel	663	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444423 rs752249293	663	N>S		No	ClinGen ExAC TOPMed gnomAD
CA353113856 rs1315914230	664	E>G		No	ClinGen gnomAD
CA353113756 rs1270365723	669	V>E		No	ClinGen gnomAD
CA353113743 rs1338379489	670	K>R		No	ClinGen gnomAD
CA2444419 rs767784352	671	N>S		No	ClinGen ExAC gnomAD
VAR_064673	674	D>E	found in a case of clear cell renal carcinoma; somatic mutation [UniProt]	No	UniProt
TCGA novel	675	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1408533735 CA353113551	677	G>S		No	ClinGen gnomAD
VAR_064674 CA353113535 rs1422119249	678	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen UniProt NCI-TCGA dbSNP gnomAD
rs1187519621 CA353113531	678	R>H		No	ClinGen gnomAD
rs764416320 CA2444416	679	R>C		No	ClinGen ExAC gnomAD
rs763078803 CA2444415	679	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	680	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444412 rs745815678	683	I>V		No	ClinGen ExAC gnomAD
CA74764676 rs113052475	691	S>P		No	ClinGen Ensembl
CA353113225 rs1227600181	692	E>Q		No	ClinGen gnomAD
rs777272973 CA2444408	695	D>N		No	ClinGen ExAC gnomAD
TCGA novel	697	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	700	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	703	P>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747614290 CA2444406	704	M>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	706	M>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA74764664 rs980527559	708	K>R		No	ClinGen Ensembl
CA353112802 rs1274200331	710	R>Q		No	ClinGen TOPMed
CA2444405 rs778396949	711	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1308843367 CA353112751	713	M>I		No	ClinGen Ensembl
rs1440617183 CA353112694	715	A>T		No	ClinGen gnomAD
rs756552548 CA2444404	716	N>D		No	ClinGen ExAC gnomAD
rs569156539 CA2444403	716	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA74764659 rs867544536	719	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1415875534 CA353112548	720	D>N		No	ClinGen gnomAD
CA2444401 rs757530012	721	I>M		No	ClinGen ExAC gnomAD
rs142097913 CA2444402	721	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs993596903 CA74764656	723	S>C		No	ClinGen TOPMed gnomAD
TCGA novel	728	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764372541 CA2444399	730	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1233447219 CA353112200	731	M>V		No	ClinGen gnomAD
rs187860752 CA2444398	735	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA353111929 rs1274619069	737	T>I		No	ClinGen gnomAD
CA353111742 rs1293010915	740	E>D		No	ClinGen TOPMed
rs1489476425 CA353111698	741	P>L		No	ClinGen TOPMed
CA2444394 rs776404492	742	E>D		No	ClinGen ExAC gnomAD
TCGA novel	742	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444392 rs770955246	747	K>R		No	ClinGen ExAC TOPMed gnomAD
CA353111413 rs1376146321	749	A>D		No	ClinGen TOPMed gnomAD
CA353111408 rs1376146321	749	A>G		No	ClinGen TOPMed gnomAD
TCGA novel	755	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760334376 CA2444391	759	T>A		No	ClinGen ExAC TOPMed gnomAD
CA353111068 rs1328407334	760	R>C		No	ClinGen gnomAD
CA2444389 rs199976998	760	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747810053 CA2444388	761	R>G		No	ClinGen ExAC TOPMed gnomAD
rs935166462 CA74764635	763	L>R		No	ClinGen TOPMed
rs1381093905 CA353110955	764	E>G		No	ClinGen Ensembl
TCGA novel	765	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1560329503 CA353110807	767	E>G		No	ClinGen Ensembl
rs768149020 CA2444386	769	S>F		No	ClinGen ExAC gnomAD
rs748868964 CA2444385	770	H>R		No	ClinGen ExAC gnomAD
rs1329110900 CA353110709	770	H>Y		No	ClinGen TOPMed
rs1190579793 CA353110688	771	V>I		No	ClinGen gnomAD
CA2444384 rs781527726	772	P>S		No	ClinGen ExAC gnomAD
rs1560328862 CA353110652	773	N>D		No	ClinGen Ensembl
TCGA novel	776	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757814394 CA2444383	778	I>T		No	ClinGen ExAC gnomAD
COSM1309364 COSM1309363 COSM1309365 CA2444382 rs751804410	779	Q>E	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA353110447 rs1464157273	781	L>F		No	ClinGen gnomAD
rs778298271 CA2444381	781	L>H		No	ClinGen ExAC gnomAD
rs1560328551 CA353110429	782	I>V		No	ClinGen Ensembl
rs752965439 CA2444379	784	N>S		No	ClinGen ExAC TOPMed gnomAD
CA353110088 rs1442174568	794	D>G		No	ClinGen gnomAD
CA353109978 rs1384458457	798	R>G		No	ClinGen gnomAD
CA2444374 rs766182437	799	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA353109902 rs760662449	801	S>I		No	ClinGen ExAC gnomAD
CA2444373 rs760662449	801	S>N		No	ClinGen ExAC gnomAD
TCGA novel	802	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353109840 rs1452465002	804	L>S		No	ClinGen gnomAD
CA2444372 rs772930853	806	E>G		No	ClinGen ExAC gnomAD
rs771839282 CA2444371	808	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1194011743 CA353109750	808	P>T		No	ClinGen gnomAD
CA353109728 rs1259143896	809	A>T		No	ClinGen gnomAD
CA74764566 rs1043720625	810	V>M		No	ClinGen TOPMed gnomAD
rs761661407 CA2444370	812	P>T		No	ClinGen ExAC gnomAD
CA2444369 rs773959868	813	N>D		No	ClinGen ExAC TOPMed gnomAD
rs768403462 CA353109573	813	N>I		No	ClinGen ExAC TOPMed gnomAD
CA2444368 rs768403462	813	N>S		No	ClinGen ExAC TOPMed gnomAD
rs768403462 CA74764561	813	N>T		No	ClinGen ExAC TOPMed gnomAD
rs748698167 CA2444367	814	F>L		No	ClinGen ExAC gnomAD
CA353109506 rs1346329402	815	P>A		No	ClinGen TOPMed gnomAD
CA353109496 rs1283107190	815	P>L		No	ClinGen TOPMed gnomAD
CA353109499 rs1283107190	815	P>R		No	ClinGen TOPMed gnomAD
CA353109508 rs1346329402	815	P>T		No	ClinGen TOPMed gnomAD
CA353109469 rs1326243655 CA353109466	816	N>K		No	ClinGen TOPMed gnomAD
rs779620657 CA2444366	816	N>S		No	ClinGen ExAC gnomAD
CA74764552 rs994266706	816	N>Y		No	ClinGen TOPMed
CA353109424 rs1293640241	818	P>L		No	ClinGen gnomAD
rs1362965282 CA353109402	820	L>V		No	ClinGen gnomAD
CA2444364 rs771658417	821	T>I		No	ClinGen ExAC TOPMed gnomAD
CA353109371 COSM191314 rs771658417	821	T>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA353109365 rs1377130464	822	F>L		No	ClinGen gnomAD
rs758808260 CA2444362	824	I>V		No	ClinGen ExAC gnomAD
TCGA novel	825	I>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1388332299 CA353108449	828	N>K		No	ClinGen TOPMed
CA353108447 rs1195116525	829	V>F		No	ClinGen gnomAD
COSM3427743 COSM3427744 CA2444360 rs146395938 COSM3427745	833	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA2444359 rs755255835	833	R>H		No	ClinGen ExAC TOPMed gnomAD
CA2444357 rs766489990	834	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs753789544 CA2444358	834	Y>H		No	ClinGen ExAC gnomAD
rs750354025 CA2444355	835	R>C		No	ClinGen ExAC TOPMed gnomAD
rs200522912 CA2444354	835	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761573345 CA2444353	836	R>Q		No	ClinGen ExAC gnomAD
COSM1424542 COSM1424543 rs1438592568 CA353108327 COSM1424544	836	R>W	kidney large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA74764506 rs183157690	837	L>V		No	ClinGen 1000Genomes
rs1046104853 CA74764502	841	Q>H		No	ClinGen TOPMed gnomAD
CA353108200 rs1412936146	842	E>G		No	ClinGen gnomAD
rs930364741 CA74764500	843	H>R		No	ClinGen TOPMed gnomAD
CA353108170 rs1313358258	844	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs774153419 CA353108125	845	F>C		No	ClinGen ExAC gnomAD
rs763587751 CA2444351	845	F>L		No	ClinGen ExAC gnomAD
rs774153419 CA2444352	845	F>S		No	ClinGen ExAC gnomAD
CA2444349 rs775065185	847	V>L		No	ClinGen ExAC
rs1462321719 CA353108019	851	A>G		No	ClinGen gnomAD
rs745413697 CA2444347	853	R>S		No	ClinGen ExAC gnomAD
TCGA novel	854	M>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1475875374 CA353107982	854	M>V		No	ClinGen gnomAD
rs1457764063 CA353107929	856	R>Q		No	ClinGen TOPMed
CA2444325 rs149186835	861	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	861	I>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444324 rs371456253	862	Y>H		No	ClinGen ESP ExAC gnomAD
rs770026090 CA2444322	865	A>G		No	ClinGen ExAC TOPMed gnomAD
rs780302565 CA2444323	865	A>T		No	ClinGen ExAC gnomAD
TCGA novel	869	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	869	Q>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	872	F>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	872	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	872	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	872	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353106255 rs1348672350	872	F>V		No	ClinGen gnomAD
TCGA novel	875	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444321 rs745908384	875	I>T		No	ClinGen ExAC gnomAD
rs1239654517 CA353106196	876	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA353106173 rs1370210377	877	D>G		No	ClinGen gnomAD
rs71299609 CA74761674	881	K>Q		No	ClinGen Ensembl
CA2444318 rs751492205	883	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs758188391 CA2444316	885	I>T		No	ClinGen ExAC gnomAD
CA353106015 rs1297138191	885	I>V		No	ClinGen TOPMed
CA353105997 rs1370481342	886	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA2444315 rs752454573	889	P>L		No	ClinGen ExAC TOPMed gnomAD
CA353105936 rs1395076055	890	A>T		No	ClinGen gnomAD
TCGA novel	892	S>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_064675 rs753344888 CA2444312	893	Y>C	found in hematopoietic, lymphoid, lung and liver cancer cell lines [UniProt]	No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs1220582073 CA353105867	894	T>A		No	ClinGen TOPMed gnomAD
rs1445546752 CA353105839	895	T>I		No	ClinGen gnomAD
VAR_064676	895	T>S	found in a lung cancer cell line [UniProt]	No	UniProt
TCGA novel	896	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1347039240 CA353105719	900	N>S		No	ClinGen gnomAD
CA353105679 rs1278117574	902	V>M		No	ClinGen TOPMed gnomAD
TCGA novel	903	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1222899722 CA353105631	904	K>Q		No	ClinGen TOPMed
TCGA novel	909	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	913	E>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA74761631 rs1001681503	914	I>T		No	ClinGen Ensembl
rs760331627 CA353105075	919	L>P		No	ClinGen ExAC gnomAD
rs760331627 CA2444310	919	L>Q		No	ClinGen ExAC gnomAD
CA353105021 rs1428187629	921	R>Q		No	ClinGen gnomAD
rs774893166 CA2444309	922	E>K		No	ClinGen ExAC gnomAD
VAR_064677	922	E>Q	found in a breast cancer cell line [UniProt]	No	UniProt
rs769094785 CA2444308	923	E>K		No	ClinGen ExAC gnomAD
CA353104944 rs1375307569	924	E>G		No	ClinGen gnomAD
rs763328959 CA2444307	924	E>K		No	ClinGen ExAC gnomAD
VAR_064678	925	K>Q	found in a colon cancer cell line [UniProt]	No	UniProt
TCGA novel	926	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	927	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749924765 CA2444291	929	E>K		No	ClinGen ExAC gnomAD
rs956368229 CA74790192	929	E>V		No	ClinGen Ensembl
rs764622654 CA2444290	931	S>G		No	ClinGen ExAC gnomAD
rs763374308 CA2444289	931	S>N		No	ClinGen ExAC gnomAD
TCGA novel	932	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353176601 rs1234239710	932	E>K		No	ClinGen TOPMed
rs765579974 CA2444287	935	S>F		No	ClinGen ExAC gnomAD
CA353176461 rs1401109882	936	G>C		No	ClinGen TOPMed
rs1385173049 CA353176456	936	G>D		No	ClinGen TOPMed
CA353176467 rs1401109882	936	G>S		No	ClinGen TOPMed
rs375764191 CA74790152	937	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs759932249 CA2444286	937	A>S		No	ClinGen ExAC gnomAD
rs375764191 CA2444285	937	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA2444284 rs771161122	938	A>V		No	ClinGen ExAC gnomAD
rs587778591 CA353176385	939	G>A		No	ClinGen TOPMed gnomAD
CA353176392 rs1232278552	939	G>S		No	ClinGen gnomAD
rs587778591 RCV000121774 CA161380	939	G>V		No	ClinGen ClinVar TOPMed dbSNP gnomAD
rs1228455931 CA353176380	940	L>F		No	ClinGen TOPMed gnomAD
TCGA novel	940	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444282 rs141067977	941	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs771983602 CA2444281	944	H>R		No	ClinGen ExAC gnomAD
rs777583945 CA74790139	944	H>Y		No	ClinGen gnomAD
rs1402934247 CA353176274	945	R>C		No	ClinGen gnomAD
rs558843390 CA2444280	945	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1470122828 CA353176094	950	D>Y		No	ClinGen TOPMed gnomAD
CA353175765 rs1211663291	956	S>I		No	ClinGen gnomAD
rs749147440 CA2444277	957	M>T		No	ClinGen ExAC TOPMed gnomAD
CA2444278 rs145255292	957	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	958	Y>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444276 rs372395774	959	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs766950254 CA2444273	962	D>G		No	ClinGen ExAC TOPMed gnomAD
rs753112917 CA2444271	964	V>A		No	ClinGen ExAC gnomAD
CA2444272 rs756858926	964	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1242877278 CA353175411	965	Y>F		No	ClinGen TOPMed
CA353175302 rs1274674750	966	V>A		No	ClinGen TOPMed gnomAD
CA2444270 rs200477547	972	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1475165913 CA353174950	976	H>R		No	ClinGen TOPMed
TCGA novel	976	H>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444269 rs759844033	977	I>V		No	ClinGen ExAC TOPMed gnomAD
COSM220149 CA353174876 rs1379809767	978	V>A	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated gnomAD
rs375687372 CA2444267	978	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	980	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA74790013 rs960330741	981	E>A		No	ClinGen TOPMed
rs1560121508 CA353174705	985	E>K		No	ClinGen Ensembl
CA353172236 rs1176569585	990	E>K		No	ClinGen gnomAD
TCGA novel	991	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	991	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA74788864 rs1035224558	992	W>*		No	ClinGen Ensembl
TCGA novel	992	W>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1259299276 CA353171975	994	Y>C		No	ClinGen gnomAD
CA2444242 rs146315609	996	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1576218709 CA353171871	996	C>W		No	ClinGen Ensembl
TCGA novel	999	Y>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750583919 CA2444241	1000	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	1004	T>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353171430 rs1248847706	1006	H>Y		No	ClinGen TOPMed
rs1258134094 CA353171377	1007	L>V		No	ClinGen gnomAD
CA353171354 rs1234499336	1008	A>T		No	ClinGen gnomAD
TCGA novel	1012	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM3824339 COSM3824340 CA353171149 rs1469145695 COSM3824341	1014	E>Q	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
TCGA novel	1016	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1017	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1178581128 CA353170868	1018	F>C		No	ClinGen TOPMed
rs774605948 CA2444238	1022	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA353170734 rs774605948	1022	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA353170672 rs1179315912	1024	N>S		No	ClinGen TOPMed
CA353170606 rs1412822043	1027	P>A		No	ClinGen gnomAD
CA353170391 rs775626700	1034	K>N		No	ClinGen ExAC gnomAD
rs1256276641 CA353170396	1034	K>R		No	ClinGen gnomAD
rs777465977 CA2444210	1044	F>S		No	ClinGen ExAC gnomAD
CA353169051 rs1454808042	1045	K>E		No	ClinGen TOPMed
rs771543116 CA2444209	1047	C>R		No	ClinGen ExAC TOPMed gnomAD
CA2444208 rs747709999	1047	C>Y		No	ClinGen ExAC gnomAD
rs187978633 CA2444207	1051	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2444206 rs756678646	1052	R>Q		No	ClinGen ExAC gnomAD
rs750687374 CA2444205	1053	D>A		No	ClinGen ExAC gnomAD
rs1055502479 CA74788281	1054	E>D		No	ClinGen TOPMed
CA353168703 rs1160034633	1054	E>Q		No	ClinGen TOPMed
TCGA novel	1055	D>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757754297 CA2444203	1062	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs781632065 CA2444204	1062	R>W		No	ClinGen ExAC TOPMed gnomAD
CA353168179 rs1323522157	1064	S>F		No	ClinGen gnomAD
rs1007067661 CA74788272	1065	A>D		No	ClinGen Ensembl
rs1390795242 CA353167884	1070	F>S		No	ClinGen gnomAD
rs201103279 CA2444201	1071	K>N		No	ClinGen 1000Genomes ExAC gnomAD
rs758502969 CA2444200	1073	I>V		No	ClinGen ExAC TOPMed gnomAD
CA2444196 rs776487197	1078	M>I		No	ClinGen ExAC TOPMed gnomAD
CA353167608 rs1252564810	1078	M>T		No	ClinGen gnomAD
CA353167585 rs1374811960	1079	P>L		No	ClinGen TOPMed
rs766154467 CA2444195	1079	P>S		No	ClinGen ExAC gnomAD
VAR_064679	1079	P>Y	requires 2 nucleotide substitutions; found in a colon cancer cell line [UniProt]	No	UniProt
rs759389631 CA74788219	1081	S>G		No	ClinGen Ensembl
rs772833716 CA2444193	1083	V>I		No	ClinGen ExAC gnomAD
rs771737225 CA2444192	1086	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1346914147 CA353167338	1087	P>L		No	ClinGen gnomAD
CA353167348 rs1346914147	1087	P>R		No	ClinGen gnomAD
CA353167313 COSM1047082 COSM1047083 COSM1047081 rs1331392443	1088	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs746373271 CA2444188	1088	R>W		No	ClinGen ExAC gnomAD
rs936829713 CA74788196	1090	V>M		No	ClinGen TOPMed gnomAD
TCGA novel	1093	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781617265 CA2444187	1093	P>L		No	ClinGen ExAC gnomAD
CA74788193 rs766031717	1093	P>T		No	ClinGen TOPMed gnomAD
rs1161005639 CA353167152	1095	V>F		No	ClinGen gnomAD
TCGA novel	1095	V>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs141958485 CA2444186	1096	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs143085435 CA2444185	1097	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA74788166 rs143085435	1097	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA2444184 rs201156614	1098	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1732135 COSM1732136 COSM1732134 rs201156614 CA2444183 VAR_064680	1098	A>S	kidney found in hematopoietic and lymphoid cancer cell lines [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt ESP ExAC TOPMed dbSNP gnomAD
rs201156614 CA353167087	1098	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	1104	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444181 rs765343290	1104	A>V		No	ClinGen ExAC gnomAD
CA2444180 rs755075248	1105	D>H		No	ClinGen ExAC gnomAD
rs917889600 CA74788130	1109	D>E		No	ClinGen Ensembl
CA2444179 rs377485917	1109	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA74788126 rs865889670	1112	N>H		No	ClinGen gnomAD
CA353166714 rs1276233437	1114	D>E		No	ClinGen TOPMed gnomAD
rs529483378 CA2444178	1114	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA353166708 rs1413331563	1115	N>D		No	ClinGen TOPMed
rs760418452 CA2444177	1115	N>S		No	ClinGen ExAC gnomAD
rs767093710 CA2444175	1116	S>A		No	ClinGen ExAC gnomAD
CA2444176 rs767093710	1116	S>P		No	ClinGen ExAC gnomAD
rs990834187 CA74788089	1118	D>G		No	ClinGen Ensembl
rs1560095469 CA353166669	1118	D>N		No	ClinGen Ensembl
rs35102895 CA74788079	1120	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2444173 VAR_064681 rs35102895	1120	R>Q	found in hematopoietic and lymphoid cancer cell lines [UniProt]	No	ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD
CA353166644 rs1341857262	1121	A>S		No	ClinGen gnomAD
rs768209099 CA2444172	1124	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1126	N>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777228498 CA2444170	1127	L>F		No	ClinGen ExAC gnomAD
CA353163722 rs1395568069	1132	E>D		No	ClinGen TOPMed
CA353163731 rs1175464873	1132	E>Q		No	ClinGen TOPMed
rs200632871 CA2444153	1133	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs200632871 CA2444154	1133	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1232088834 CA353163692	1135	P>A		No	ClinGen gnomAD
TCGA novel	1135	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444152 rs762485022	1136	V>L		No	ClinGen ExAC gnomAD
rs1458775323 CA353163664	1137	E>V		No	ClinGen gnomAD
CA2444150 rs373854321	1140	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141109671 CA74783840	1145	C>Y		No	ClinGen ESP
rs761247872 CA2444149	1146	H>Q		No	ClinGen ExAC gnomAD
TCGA novel	1147	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773919133 CA74783825	1148	F>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1150	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772449438 CA2444147	1152	H>R		No	ClinGen ExAC gnomAD
CA353163367 rs1165848783	1154	N>S		No	ClinGen TOPMed gnomAD
rs748508046 CA2444146	1156	M>T		No	ClinGen ExAC TOPMed gnomAD
CA353163342 rs1306278787	1156	M>V		No	ClinGen TOPMed
rs1348177372 CA353163223	1163	C>S		No	ClinGen TOPMed gnomAD
TCGA novel	1164	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768794473 CA2444144	1166	I>L		No	ClinGen ExAC gnomAD
CA353163111 rs1405871349	1169	H>Y		No	ClinGen gnomAD
rs780124443 CA2444142	1173	R>C		No	ClinGen ExAC gnomAD
rs1318993618 CA353163032	1173	R>H		No	ClinGen TOPMed
TCGA novel	1174	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1175	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369155727 CA2444140	1176	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA353162928 rs369155727	1176	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
VAR_064682	1177	G>S	found in a kidney cancer cell line [UniProt]	No	UniProt
rs533143558 CA2444139	1178	R>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1360491739 CA353161296	1180	E>K		No	ClinGen gnomAD
CA2444112 rs753432959	1185	R>Q		No	ClinGen ExAC gnomAD
CA74782069 rs866217387	1189	A>T		No	ClinGen Ensembl
TCGA novel	1195	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1197	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353159713 rs1467942087	1202	T>A		No	ClinGen TOPMed gnomAD
rs764361753 CA2444108	1202	T>I		No	ClinGen ExAC gnomAD
TCGA novel	1202	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1203	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_064683	1204	H>P	found in a case of clear cell renal carcinoma; somatic mutation [UniProt]	No	UniProt
TCGA novel	1206	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1209	M>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_064684	1209	M>del	found in a case of clear cell renal carcinoma; somatic mutation [UniProt]	No	UniProt
rs775669754 CA2444106	1212	K>R		No	ClinGen ExAC gnomAD
CA2444105 rs770026172	1215	V>I		No	ClinGen ExAC gnomAD
TCGA novel	1216	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353159021 rs1575920780	1219	N>Y		No	ClinGen Ensembl
CA74782038 rs79886237	1220	L>R		No	ClinGen 1000Genomes
TCGA novel	1222	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444103 rs776585540	1223	T>A		No	ClinGen ExAC TOPMed gnomAD
CA2444102 rs771100470	1227	T>A		No	ClinGen ExAC gnomAD
CA2444101 rs746915869	1228	C>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1228	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1047080 COSM1047078 rs1311960562 CA353158435 COSM1047079	1231	G>R	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs763255409 CA2444087	1232	K>Q		No	ClinGen ExAC gnomAD
CA353152547 rs1559900408	1233	C>S		No	ClinGen Ensembl
rs143617370 CA74772456	1234	A>T		No	ClinGen ESP gnomAD
CA353152456 rs1332979792	1236	L>M		No	ClinGen gnomAD
CA74772454 rs868202591	1236	L>S		No	ClinGen Ensembl
CA353152327 rs1389353528	1240	D>N		No	ClinGen gnomAD
rs1257279713 CA353152285	1241	F>L		No	ClinGen TOPMed
rs924732981 CA74772452	1242	L>P		No	ClinGen TOPMed
rs775835528 CA2444086	1244	C>F		No	ClinGen ExAC gnomAD
rs765383171 CA2444085	1248	E>D		No	ClinGen ExAC gnomAD
CA353152113 rs1370836009	1249	I>V		No	ClinGen gnomAD
rs1370720673 CA353151999	1250	P>L		No	ClinGen gnomAD
rs1575655277 CA353151927	1252	N>D		No	ClinGen Ensembl
TCGA novel	1252	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444084 rs759740227	1253	D>A		No	ClinGen ExAC gnomAD
CA2444083 rs776977630	1254	I>V		No	ClinGen ExAC gnomAD
TCGA novel	1257	C>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353151604 rs1180718174	1260	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	1260	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444082 rs560772391	1261	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs982726266 CA74772437	1262	N>S		No	ClinGen Ensembl
rs1266754347 CA353151429	1264	S>N		No	ClinGen TOPMed gnomAD
CA2444080 rs772970975	1265	D>N		No	ClinGen ExAC gnomAD
rs772163973 CA2444079	1268	M>I		No	ClinGen ExAC gnomAD
CA353151152 rs1409501820	1271	F>L		No	ClinGen TOPMed
rs1239100370 CA353151122	1272	K>R		No	ClinGen gnomAD
rs778866834 CA2444077	1274	L>S		No	ClinGen ExAC gnomAD
CA2444075 rs748892487	1276	R>S		No	ClinGen ExAC TOPMed gnomAD
rs149630630 CA2444076	1276	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs755557896 CA2444073	1279	L>F		No	ClinGen ExAC gnomAD
CA2444071 rs778215010	1280	S>P		No	ClinGen ExAC TOPMed gnomAD
rs758918362 CA2444070	1281	A>P		No	ClinGen ExAC gnomAD
CA2444069 rs150890583	1282	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs765581705 CA2444068	1283	V>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1283	V>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444066 rs753982008	1284	V>A		No	ClinGen ExAC TOPMed gnomAD
CA74772359 rs376747486	1284	V>I		No	ClinGen ESP TOPMed
rs111483865 CA74772342	1285	D>G		No	ClinGen Ensembl
VAR_064685	1287	E>Q	found in a breast cancer cell line [UniProt]	No	UniProt
CA353150615 rs1212361524	1288	I>T		No	ClinGen TOPMed
TCGA novel	1293	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353150174 rs1280677016	1295	I>T		No	ClinGen gnomAD
rs767705285 CA2444043	1295	I>V		No	ClinGen ExAC TOPMed gnomAD
rs776550567 CA2444041	1297	P>A		No	ClinGen ExAC gnomAD
rs776550567 CA2444042	1297	P>S		No	ClinGen ExAC gnomAD
CA353150067 rs1340217547	1298	Q>L		No	ClinGen gnomAD
CA353150008 rs1332685249	1300	E>K		No	ClinGen gnomAD
rs1416373254 CA353149842	1305	L>P		No	ClinGen gnomAD
rs948355658 CA74771862	1307	K>E		No	ClinGen gnomAD
rs1464165958 CA353149754	1307	K>R		No	ClinGen gnomAD
TCGA novel	1315	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444038 rs146951964	1317	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs199643728 COSM1566688 COSM1566687 CA2444036 COSM1566686	1318	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1292028795 CA353149116	1321	G>S		No	ClinGen TOPMed
CA353149085 rs1559891938	1322	G>R		No	ClinGen Ensembl
TCGA novel	1322	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs933552056 CA74771822	1323	D>E		No	ClinGen TOPMed
rs1461443682 CA353149041	1323	D>N		No	ClinGen gnomAD
rs907961765 CA74771817	1325	D>G		No	ClinGen gnomAD
CA353148831 rs1245694711	1327	E>A		No	ClinGen TOPMed
rs545777783 CA2444034	1330	G>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1250831550 CA353148596	1332	E>K		No	ClinGen TOPMed
rs771196068 CA74771798	1332	E>V		No	ClinGen Ensembl
TCGA novel	1337	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779348260 CA2444032	1337	I>T		No	ClinGen ExAC gnomAD
rs933331364 CA74771783	1337	I>V		No	ClinGen gnomAD
rs1215663620 CA353148206	1339	P>A		No	ClinGen TOPMed gnomAD
TCGA novel	1339	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353148194 rs1356335816	1339	P>R		No	ClinGen gnomAD
rs755510462 CA2444031	1340	P>A		No	ClinGen ExAC gnomAD
rs578206243 CA2444030	1340	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	1340	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs975052107 CA74771739	1341	S>P		No	ClinGen Ensembl
rs780455849 CA2444029	1342	L>V		No	ClinGen ExAC
CA353148106 rs1275568834	1343	P>H		No	ClinGen TOPMed
CA2444027 rs750646675	1344	Q>L		No	ClinGen ExAC gnomAD
TCGA novel	1346	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767904372 CA353147968	1347	T>I		No	ClinGen ExAC TOPMed gnomAD
rs767904372 CA2444026	1347	T>N		No	ClinGen ExAC TOPMed gnomAD
CA353147993 rs1575642238	1347	T>P		No	ClinGen Ensembl
rs767904372 CA353147972	1347	T>S		No	ClinGen ExAC TOPMed gnomAD
CA353147932 rs1171303700	1348	P>H		No	ClinGen TOPMed gnomAD
CA353147930 rs1171303700	1348	P>R		No	ClinGen TOPMed gnomAD
rs989942540 CA74771704	1348	P>S		No	ClinGen TOPMed
CA2444023 rs763872667	1350	A>V		No	ClinGen ExAC TOPMed
CA2444022 rs762933159	1354	D>N		No	ClinGen ExAC gnomAD
rs775355986 CA2444021	1356	M>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1357	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2444020 rs369597128	1358	Y>C		No	ClinGen ESP ExAC gnomAD
CA2444018 rs776212770	1359	T>I		No	ClinGen ExAC TOPMed gnomAD
CA353147391 rs1404713077	1360	P>A		No	ClinGen TOPMed
TCGA novel	1360	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353147369 rs1232942838	1360	P>L		No	ClinGen gnomAD
rs1404713077 CA353147400	1360	P>T		No	ClinGen TOPMed
TCGA novel	1361	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353147343 rs1031849363	1361	P>L		No	ClinGen TOPMed gnomAD
CA74771662 rs1031849363	1361	P>Q		No	ClinGen TOPMed gnomAD
CA353147349 rs1220205958	1361	P>S		No	ClinGen gnomAD
CA2444017 rs770598673	1362	Q>L		No	ClinGen ExAC gnomAD
rs1285350121 CA353145722	1363	S>A		No	ClinGen TOPMed gnomAD
rs1259783148 CA353145682	1365	P>A		No	ClinGen gnomAD
CA353145664 rs1243758907	1366	K>Q		No	ClinGen TOPMed
rs776411864 CA353145602	1367	S>A		No	ClinGen ExAC gnomAD
rs371730711 CA2443999	1367	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs776411864 CA2444000	1367	S>T		No	ClinGen ExAC gnomAD
rs1455184698 CA353145541	1368	A>V		No	ClinGen gnomAD
rs1174894328 CA353145432	1370	G>D		No	ClinGen gnomAD
rs1431131355 CA353145405	1371	S>C		No	ClinGen gnomAD
TCGA novel	1376	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353145156 rs1199584083	1376	G>A		No	ClinGen TOPMed gnomAD
CA353145138 rs1199584083	1376	G>V		No	ClinGen TOPMed gnomAD
CA2443995 rs200783965	1377	S>C		No	ClinGen ExAC TOPMed gnomAD
CA2443996 rs200783965	1377	S>F		No	ClinGen ExAC TOPMed gnomAD
CA2443994 rs367999949	1381	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs554829380 CA2443992	1386	Y>*		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	1386	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2443991 rs781702167	1387	I>N		No	ClinGen ExAC
rs1261731565 CA353144808	1388	L>V		No	ClinGen gnomAD
rs1209675086 CA353144759	1390	S>I		No	ClinGen gnomAD
TCGA novel	1391	S>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1310725440 CA353144654	1393	M>I		No	ClinGen gnomAD
TCGA novel	1394	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2443990 rs771487360	1397	I>V		No	ClinGen ExAC TOPMed gnomAD
CA353144530 rs1575614506	1399	A>G		No	ClinGen Ensembl
CA353144528 rs1575614506	1399	A>V		No	ClinGen Ensembl
TCGA novel	1400	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1276256973 CA353144361	1407	G>R		No	ClinGen gnomAD
rs111345980 CA74770663	1410	S>G		No	ClinGen Ensembl
VAR_064686	1414	G>E	found in a lung cancer cell line [UniProt]	No	UniProt
rs1314009029 CA353143917	1421	E>D		No	ClinGen Ensembl
CA353143867 rs1362364948	1422	T>I		No	ClinGen TOPMed gnomAD
CA353143854 rs1302111374	1423	A>V		No	ClinGen gnomAD
CA2443987 rs758454919 COSM125145	1430	E>K	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA353142044 rs1394076628	1431	R>Q		No	ClinGen gnomAD
CA353141948 rs1293429170	1435	V>F		No	ClinGen gnomAD
CA74764655 rs561610279	1441	R>S		No	ClinGen TOPMed gnomAD
rs1337009790 CA353141738	1443	R>*		No	ClinGen gnomAD
CA353141724 rs1445647299	1443	R>Q		No	ClinGen gnomAD
rs1575573284 CA353141530	1449	Q>H		No	ClinGen Ensembl
CA353141461 rs1169202794	1451	S>C		No	ClinGen gnomAD
rs1463927694 CA353141415	1453	S>T		No	ClinGen gnomAD
rs1413760303 CA353141402	1453	S>Y		No	ClinGen TOPMed gnomAD
rs1364896872 CA353141351	1454	P>A		No	ClinGen TOPMed
CA353141335 rs1353215997	1455	R>*		No	ClinGen gnomAD
rs968064758 CA74764654	1455	R>Q		No	ClinGen TOPMed gnomAD
CA353141184 rs1319985402	1460	V>L		No	ClinGen TOPMed gnomAD
CA74764649 rs1022754387	1462	A>G		No	ClinGen Ensembl
rs1443187477 CA353141135	1462	A>T		No	ClinGen gnomAD
rs1046200702 CA74764647	1463	L>V		No	ClinGen TOPMed
CA353140976 rs1575572432	1466	V>G		No	ClinGen Ensembl
CA353140687 rs1184403991	1471	T>A		No	ClinGen gnomAD
TCGA novel	1472	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1457533311 CA353140614	1473	M>V		No	ClinGen TOPMed gnomAD
CA74764644 rs1009486215	1476	L>F		No	ClinGen Ensembl
rs1463000203 CA353140416	1477	N>S		No	ClinGen gnomAD
CA74764642 rs1014343852	1478	Q>R		No	ClinGen TOPMed
CA353140169 rs1242773031	1482	P>S		No	ClinGen TOPMed
rs892381016 CA74764641	1484	A>T		No	ClinGen Ensembl
CA2443972 rs771399361	1485	G>V		No	ClinGen ExAC gnomAD
rs747399046 CA2443971	1487	M>I		No	ClinGen ExAC gnomAD
rs778015952 CA2443970	1489	G>C		No	ClinGen ExAC TOPMed gnomAD
CA2443969 rs772183616	1491	P>L		No	ClinGen ExAC gnomAD
TCGA novel	1493	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2443967 rs778843055	1494	L>V		No	ClinGen ExAC gnomAD
rs755115410 CA2443966	1495	P>L		No	ClinGen ExAC TOPMed gnomAD
CA74763483 rs368586641	1500	P>T		No	ClinGen Ensembl
rs780018691 CA353137961	1501	V>A		No	ClinGen ExAC TOPMed gnomAD
CA2443964 rs780018691	1501	V>G		No	ClinGen ExAC TOPMed gnomAD
rs1184034549 CA353137935	1502	D>G		No	ClinGen gnomAD
VAR_064687	1503	G>C	found in a stomach cancer cell line [UniProt]	No	UniProt
rs534391770 CA2443962	1503	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA353137863 rs1220119933	1503	G>V		No	ClinGen gnomAD
CA353137830 rs1417216069	1505	V>I		No	ClinGen Ensembl
rs1575527612 CA353137721	1507	M>R		No	ClinGen Ensembl
rs761386514 CA74763465	1509	S>G		No	ClinGen ExAC gnomAD
rs761386514 CA2443960	1509	S>R		No	ClinGen ExAC gnomAD
rs1575527424 CA353137565	1510	M>I		No	ClinGen Ensembl
TCGA novel	1511	Q>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1006304898 CA74763458	1512	P>Q		No	ClinGen Ensembl
CA353137382 rs201036766	1515	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201036766 CA2443959	1515	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA74763435 rs950807031	1517	G>E		No	ClinGen gnomAD
rs1559827261	1518	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1026241998 CA74763427	1518	P>T		No	ClinGen gnomAD
rs554813783 CA74763412	1519	P>L		No	ClinGen gnomAD
rs1429210453 CA353137191	1520	P>S		No	ClinGen TOPMed
rs762598795 CA2443957	1521	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA353137077 rs1234047813	1522	H>Q		No	ClinGen TOPMed
CA353137123 rs1368022648	1522	H>R		No	ClinGen gnomAD
rs1304065662 CA353137049	1523	L>F		No	ClinGen TOPMed gnomAD
COSM4150009 COSM4150010 rs777226267 CA2443956	1524	P>L	ovary [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1377136421 CA353136876	1526	G>A		No	ClinGen gnomAD
rs1377136421 CA353136884	1526	G>D		No	ClinGen gnomAD
rs761034188 CA2443954	1526	G>R		No	ClinGen ExAC gnomAD
CA2443953 rs143564112 COSM1235550	1527	V>M	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA353136742 rs1201304205	1530	L>V		No	ClinGen TOPMed
CA353136684 rs1269557269	1531	P>L		No	ClinGen TOPMed gnomAD
CA353136665 rs1445391511	1532	G>D		No	ClinGen TOPMed
CA353136556 rs1248596646	1535	P>S		No	ClinGen TOPMed
CA2443951 rs145488469	1536	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2443952 rs772543387	1536	P>S		No	ClinGen ExAC gnomAD
CA74761634 rs143661199	1538	V>M		No	ClinGen ESP
rs1032546493 CA74761632	1540	N>K		No	ClinGen TOPMed gnomAD
CA353134443 rs1228651034	1543	V>A		No	ClinGen gnomAD
rs767739463 CA2443935	1544	A>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1544	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2443934 COSM1692826 rs762288924 COSM1692825 COSM1692824	1544	A>V	skin [Cosmic]	No	ClinGen cosmic curated ExAC
rs774508637 CA2443933	1546	M>V		No	ClinGen ExAC gnomAD
rs1406912189 CA353134310	1547	V>A		No	ClinGen TOPMed gnomAD
rs1454816622 CA353134330	1547	V>L		No	ClinGen gnomAD
rs768897886 CA2443932	1549	T>A		No	ClinGen ExAC gnomAD
rs749299765 CA2443931	1550	P>L		No	ClinGen ExAC gnomAD
CA353134211 rs1425385514	1550	P>T		No	ClinGen TOPMed
rs1383208960 CA353134124	1552	P>L		No	ClinGen gnomAD
rs769978319 CA2443929	1553	G>C		No	ClinGen ExAC gnomAD
rs1237019614 CA353134102	1553	G>D		No	ClinGen gnomAD
TCGA novel	1558	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_064688	1560	Q>H	found in an endometrial cancer cell line [UniProt]	No	UniProt
TCGA novel	1560	Q>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778674241 CA2443900	1561	V>L		No	ClinGen ExAC gnomAD
rs778674241 CA2443901	1561	V>M		No	ClinGen ExAC gnomAD
TCGA novel	1562	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2443899 rs754399493	1564	L>F		No	ClinGen ExAC gnomAD
TCGA novel	1564	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2443898 COSM1732214 COSM1732215 COSM1732213 rs753421798	1566	P>L	kidney [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA2443897 rs199944513	1567	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757796273 CA2443896	1569	Q>P		No	ClinGen ExAC gnomAD
rs1559796714 CA353133230	1571	A>V		No	ClinGen Ensembl
CA353133174 rs1371444327	1573	P>A		No	ClinGen TOPMed
CA353133133 rs1559796529	1574	P>A		No	ClinGen Ensembl
rs1559796469 CA353133098	1575	Y>H		No	ClinGen Ensembl
CA2443894 rs764441740	1576	P>A		No	ClinGen ExAC gnomAD
CA2443892 rs200150658	1577	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs765524945 CA2443891	1577	G>V		No	ClinGen ExAC gnomAD
rs1037568674 CA74761420	1578	P>S		No	ClinGen TOPMed
CA353132959 rs1321286512	1579	H>N		No	ClinGen gnomAD
rs767731304 CA2443889	1580	P>A		No	ClinGen ExAC gnomAD
CA2443888 rs770973480	1580	P>L		No	ClinGen ExAC TOPMed gnomAD
CA353132902 rs1361004473	1581	A>T		No	ClinGen gnomAD
CA2443887 rs760685169	1582	G>E		No	ClinGen ExAC gnomAD
rs1433971214 CA353132870	1583	P>R		No	ClinGen TOPMed
rs144852450 CA2443886 RCV000487857	1583	P>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs144852450 CA353132877	1583	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201088500 CA2443885	1584	P>H		No	ClinGen ExAC gnomAD
rs201088500 CA2443884	1584	P>R		No	ClinGen ExAC gnomAD
CA353132859 rs1345421279	1584	P>S		No	ClinGen TOPMed gnomAD
CA2443881 rs768360550	1590	T>A		No	ClinGen ExAC gnomAD
rs1327703585 CA353132653	1594	F>C		No	ClinGen TOPMed
TCGA novel	1594	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201684321 CA2443879	1595	V>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1486933581 CA353132620	1596	A>S		No	ClinGen gnomAD
rs1242947239 CA353132614	1596	A>V		No	ClinGen gnomAD
rs1338391321 CA353132597	1597	P>T		No	ClinGen gnomAD
rs1203327562 CA353132469	1602	Q>R		No	ClinGen gnomAD
CA2443878 rs563717316	1603	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	1605	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1607	S>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1608	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778303337 CA2443876	1612	K>R		No	ClinGen ExAC gnomAD
VAR_064689	1614	I>N	found in a case of clear cell renal carcinoma; somatic mutation [UniProt]	No	UniProt
TCGA novel	1618	S>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV000121775 rs142726131 CA161382	1619	A>V		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1027009830 CA74761318	1621	S>P		No	ClinGen gnomAD
rs995580383 CA74761317	1623	S>N		No	ClinGen Ensembl
CA353131866 rs1362157547	1624	I>V		No	ClinGen gnomAD
CA353131671 rs1575460572	1628	D>G		No	ClinGen Ensembl
rs1335652201 CA353131680	1628	D>Y		No	ClinGen gnomAD
rs1450064934 CA353131664	1629	Q>*		No	ClinGen gnomAD
CA2443874 rs765315890	1631	L>V		No	ClinGen ExAC TOPMed gnomAD
CA353131582 rs1466953081	1632	A>S		No	ClinGen gnomAD
rs1373014199 CA353131564	1633	A>T		No	ClinGen gnomAD
CA2443856 rs375268569	1634	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1163354335 CA353130696	1636	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs879167521 CA74759660	1636	R>H		No	ClinGen TOPMed gnomAD
RCV000121776 CA161384 rs201397730	1637	D>N		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs779331178 CA2443854	1638	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1178877286 CA353130591	1639	H>R		No	ClinGen gnomAD
rs907606869 CA74759616	1640	L>F		No	ClinGen Ensembl
rs1307117980 CA353130548	1641	S>L		No	ClinGen TOPMed
TCGA novel	1644	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA353130448 rs1224208524	1644	Q>R		No	ClinGen TOPMed
CA353130369 rs1219982536	1646	S>N		No	ClinGen TOPMed gnomAD
CA2443851 VAR_064690 rs200020801	1647	R>C	found in a breast cancer cell line [UniProt]	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2443850 rs376146705	1647	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA353130168 rs1351647250	1651	H>Q		No	ClinGen gnomAD
CA74759590 rs1013158855	1651	H>R		No	ClinGen TOPMed
rs761798603 CA2443847	1654	K>R		No	ClinGen ExAC
CA74759576 rs977027732	1655	S>T		No	ClinGen Ensembl
rs1457817627 CA353129999	1656	K>R		No	ClinGen TOPMed
rs1302879949 CA353129979	1657	G>R		No	ClinGen gnomAD
rs964321410 CA74759575	1659	H>D		No	ClinGen Ensembl
CA353129920 rs1423149207	1660	T>N		No	ClinGen gnomAD
CA353129918 rs1423149207	1660	T>S		No	ClinGen gnomAD
rs1575421603 CA353129754	1666	L>F		No	ClinGen Ensembl
rs1436814738 CA353129706	1668	R>C		No	ClinGen gnomAD
rs1367900513 CA353129700	1668	R>H		No	ClinGen gnomAD
CA353129634 rs1164015194	1670	R>*		No	ClinGen gnomAD
CA353129608 rs1413674197	1671	D>N		No	ClinGen TOPMed
rs200304933 CA74759567	1675	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA TOPMed gnomAD
rs763922587 CA2443845	1677	T>A		No	ClinGen ExAC gnomAD
rs781198711 CA74759549	1679	N>S		No	ClinGen TOPMed
rs775162970 CA2443843	1681	R>C		No	ClinGen ExAC TOPMed gnomAD
CA74759523 rs775162970	1681	R>G		No	ClinGen ExAC TOPMed gnomAD
CA2443842 rs371624499	1681	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs761719532 CA74759503	1682	Q>*		No	ClinGen ExAC gnomAD
rs761719532 CA2443841	1682	Q>K		No	ClinGen ExAC gnomAD
CA2443840 rs776101324	1684	Y>D		No	ClinGen ExAC TOPMed gnomAD
rs770490657 CA2443839	1685	N>H		No	ClinGen ExAC
CA353128978 rs1348114882	1685	N>K		No	ClinGen gnomAD
TCGA novel	1687	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

1 associated diseases with Q86U86

[MIM: 144700]: Renal cell carcinoma (RCC)

Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. {ECO:0000269|PubMed:21248752}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. {ECO:0000269|PubMed:21248752}. Note=The disease is caused by variants affecting the gene represented in this entry.

15 regional properties for Q86U86

Type	Name	Position	InterPro Accession
domain	Bromo adjacent homology (BAH) domain	956 - 1074	IPR001025-1
domain	Bromo adjacent homology (BAH) domain	1156 - 1272	IPR001025-2
domain	Bromodomain	43 - 153	IPR001487-1
domain	Bromodomain	175 - 289	IPR001487-2
domain	Bromodomain	379 - 489	IPR001487-3
domain	Bromodomain	516 - 627	IPR001487-4
domain	Bromodomain	651 - 765	IPR001487-5
domain	Bromodomain	775 - 881	IPR001487-6
domain	High mobility group box domain	1378 - 1448	IPR009071
conserved_site	Bromodomain, conserved site	72 - 126	IPR018359-1
conserved_site	Bromodomain, conserved site	205 - 262	IPR018359-2
conserved_site	Bromodomain, conserved site	405 - 462	IPR018359-3
conserved_site	Bromodomain, conserved site	548 - 600	IPR018359-4
conserved_site	Bromodomain, conserved site	681 - 738	IPR018359-5
domain	Protein polybromo-1, Bromodomain 5	658 - 762	IPR037968

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
kinetochore	A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
nuclear chromosome	A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
nuclear matrix	The dense fibrillar network lying on the inner side of the nuclear membrane.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
RSC-type complex	A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining.
SWI/SNF complex	A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof.

2 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

12 GO annotations of biological process

Name	Definition
chromatin remodeling	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
positive regulation of cell differentiation	Any process that activates or increases the frequency, rate or extent of cell differentiation.
positive regulation of double-strand break repair	Any process that activates or increases the frequency, rate or extent of double-strand break repair.
positive regulation of myoblast differentiation	Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
positive regulation of T cell differentiation	Any process that activates or increases the frequency, rate or extent of T cell differentiation.
regulation of G0 to G1 transition	A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase.
regulation of G1/S transition of mitotic cell cycle	Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
regulation of mitotic metaphase/anaphase transition	Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
regulation of nucleotide-excision repair	Any process that modulates the frequency, rate or extent of nucleotide-excision repair.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8BSQ9	Pbrm1	Protein polybromo-1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MGSKRRRATS	PSSSVSGDFD	DGHHSVSTPG	PSRKRRRLSN	LPTVDPIAVC	HELYNTIRDY
70	80	90	100	110	120
KDEQGRLLCE	LFIRAPKRRN	QPDYYEVVSQ	PIDLMKIQQK	LKMEEYDDVN	LLTADFQLLF
130	140	150	160	170	180
NNAKSYYKPD	SPEYKAACKL	WDLYLRTRNE	FVQKGEADDE	DDDEDGQDNQ	GTVTEGSSPA
190	200	210	220	230	240
YLKEILEQLL	EAIVVATNPS	GRLISELFQK	LPSKVQYPDY	YAIIKEPIDL	KTIAQRIQNG
250	260	270	280	290	300
SYKSIHAMAK	DIDLLAKNAK	TYNEPGSQVF	KDANSIKKIF	YMKKAEIEHH	EMAKSSLRMR
310	320	330	340	350	360
TPSNLAAARL	TGPSHSKGSL	GEERNPTSKY	YRNKRAVQGG	RLSAITMALQ	YGSESEEDAA
370	380	390	400	410	420
LAAARYEEGE	SEAESITSFM	DVSNPFYQLY	DTVRSCRNNQ	GQLIAEPFYH	LPSKKKYPDY
430	440	450	460	470	480
YQQIKMPISL	QQIRTKLKNQ	EYETLDHLEC	DLNLMFENAK	RYNVPNSAIY	KRVLKLQQVM
490	500	510	520	530	540
QAKKKELARR	DDIEDGDSMI	SSATSDTGSA	KRKSKKNIRK	QRMKILFNVV	LEAREPGSGR
550	560	570	580	590	600
RLCDLFMVKP	SKKDYPDYYK	IILEPMDLKI	IEHNIRNDKY	AGEEGMIEDM	KLMFRNARHY
610	620	630	640	650	660
NEEGSQVYND	AHILEKLLKE	KRKELGPLPD	DDDMASPKLK	LSRKSGISPK	KSKYMTPMQQ
670	680	690	700	710	720
KLNEVYEAVK	NYTDKRGRRL	SAIFLRLPSR	SELPDYYLTI	KKPMDMEKIR	SHMMANKYQD
730	740	750	760	770	780
IDSMVEDFVM	MFNNACTYNE	PESLIYKDAL	VLHKVLLETR	RDLEGDEDSH	VPNVTLLIQE
790	800	810	820	830	840
LIHNLFVSVM	SHQDDEGRCY	SDSLAEIPAV	DPNFPNKPPL	TFDIIRKNVE	NNRYRRLDLF
850	860	870	880	890	900
QEHMFEVLER	ARRMNRTDSE	IYEDAVELQQ	FFIKIRDELC	KNGEILLSPA	LSYTTKHLHN
910	920	930	940	950	960
DVEKERKEKL	PKEIEEDKLK	REEEKREAEK	SEDSSGAAGL	SGLHRTYSQD	CSFKNSMYHV
970	980	990	1000	1010	1020
GDYVYVEPAE	ANLQPHIVCI	ERLWEDSAGE	KWLYGCWFYR	PNETFHLATR	KFLEKEVFKS
1030	1040	1050	1060	1070	1080
DYYNKVPVSK	ILGKCVVMFV	KEYFKLCPEN	FRDEDVFVCE	SRYSAKTKSF	KKIKLWTMPI
1090	1100	1110	1120	1130	1140
SSVRFVPRDV	PLPVVRVASV	FANADKGDDE	KNTDNSEDSR	AEDNFNLEKE	KEDVPVEMSN
1150	1160	1170	1180	1190	1200
GEPGCHYFEQ	LHYNDMWLKV	GDCVFIKSHG	LVRPRVGRIE	KVWVRDGAAY	FYGPIFIHPE
1210	1220	1230	1240	1250	1260
ETEHEPTKMF	YKKEVFLSNL	EETCPMTCIL	GKCAVLSFKD	FLSCRPTEIP	ENDILLCESR
1270	1280	1290	1300	1310	1320
YNESDKQMKK	FKGLKRFSLS	AKVVDDEIYY	FRKPIVPQKE	PSPLLEKKIQ	LLEAKFAELE
1330	1340	1350	1360	1370	1380
GGDDDIEEMG	EEDSEVIEPP	SLPQLQTPLA	SELDLMPYTP	PQSTPKSAKG	SAKKEGSKRK
1390	1400	1410	1420	1430	1440
INMSGYILFS	SEMRAVIKAQ	HPDYSFGELS	RLVGTEWRNL	ETAKKAEYEE	RAAKVAEQQE
1450	1460	1470	1480	1490	1500
RERAAQQQQP	SASPRAGTPV	GALMGVVPPP	TPMGMLNQQL	TPVAGMMGGY	PPGLPPLQGP
1510	1520	1530	1540	1550	1560
VDGLVSMGSM	QPLHPGGPPP	HHLPPGVPGL	PGIPPPGVMN	QGVAPMVGTP	APGGSPYGQQ
1570	1580	1590	1600	1610	1620
VGVLGPPGQQ	APPPYPGPHP	AGPPVIQQPT	TPMFVAPPPK	TQRLLHSEAY	LKYIEGLSAE
1630	1640	1650	1660	1670	1680
SNSISKWDQT	LAARRRDVHL	SKEQESRLPS	HWLKSKGAHT	TMADALWRLR	DLMLRDTLNI

RQAYNLENV