Q80ZV0
Gene name |
Rnaseh2b (Dleu8) |
Protein name |
Ribonuclease H2 subunit B |
Names |
RNase H2 subunit B, Deleted in lymphocytic leukemia 8 homolog, Ribonuclease HI subunit B |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67153 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q80ZV0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3KIO | X-ray | 290 A | B | 1-308 | PDB |
| 3P5J | X-ray | 290 A | B | 1-308 | PDB |
| AF-Q80ZV0-F1 | Predicted | AlphaFoldDB |
12 variants for Q80ZV0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs245816148 | 22 | H>Y | No | EVA | |
| rs228060171 | 46 | G>V | No | EVA | |
| rs3389335819 | 63 | I>M | No | EVA | |
| rs227425961 | 71 | H>R | No | EVA | |
| rs3389332191 | 96 | L>M | No | EVA | |
| rs223741815 | 120 | D>N | No | EVA | |
| rs240785799 | 121 | T>M | No | EVA | |
| rs47551267 | 135 | E>K | No | EVA | |
| rs256763742 | 239 | T>P | No | EVA | |
| rs3389348311 | 244 | K>E | No | EVA | |
| rs3389299457 | 244 | K>M | No | EVA | |
| rs3389291242 | 308 | I>F | No | EVA |
No associated diseases with Q80ZV0
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| ribonuclease H2 complex | A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| fibroblast proliferation | The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. |
| gene expression | The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. |
| in utero embryonic development | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
| mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of fibroblast proliferation | Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. |
| regulation of DNA damage checkpoint | Any process that modulates the frequency, rate or extent of a DNA damage checkpoint. |
| regulation of G2/M transition of mitotic cell cycle | Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. |
| ribonucleotide metabolic process | The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. |
| RNA catabolic process | The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGGRDRGDL | AARQLVFLLP | EHLKDASKKK | KKSSLLFVKL | ANPHSGEGAT | YLIDMCLQQL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FEIKVFKEKH | HSWFINQSVQ | SGGLLHFATP | MDPLFLLLHY | LLKAGKEGKY | QPLDQVVVDD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TFPDCTLLLR | FPELEKSLRH | VTEEKEVNSK | KYYKYSSEKT | LKWLEKKVNQ | TVVALKANNV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NVGARVQSSA | YFSGGQVSRD | KEEDYVRYAH | GLISDYIPKE | LSDDLSKFLK | LPEPPASLTN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PPSKKLKLSD | EPVEAKEDYT | KFNTKDLKTG | KKNSKMTAAQ | KALAKVDKSG | MKSIDAFFGA |
| KNKKTGKI |