AiPD: Autoinhibited Protein Database

Gene name	Ccdc181
Protein name	Coiled-coil domain-containing protein 181
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:74895
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

318-400 (Predicted disordered autoinhibitory region) PR

318-400 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q80ZU5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs237398545	37	T>I	No	EVA
rs3388510315	50	Q>*	No	EVA
rs3388512603	79	R>K	No	EVA
rs3388511918	91	P>L	No	EVA
rs3388511585	95	I>M	No	EVA
rs3388509548	117	D>E	No	EVA
rs3388511926	117	D>N	No	EVA
rs32692867	137	L>V	No	EVA
rs3388509908	138	L>P	No	EVA
rs3388512638	155	K>I	No	EVA
rs3388512082	159	V>I	No	EVA
rs3388512649	162	E>A	No	EVA
rs3388511993	163	V>I	No	EVA
rs3388511610	185	K>I	No	EVA
rs3388511037	215	K>E	No	EVA
rs3388510983	245	N>I	No	EVA
rs3388510107	272	E>G	No	EVA
rs261930920	275	G>V	No	EVA
rs31608783	280	I>L	No	EVA
rs253998455	313	A>T	No	EVA
rs3388510991	353	K>M	No	EVA
rs45906894	468	E>Q	No	EVA
rs3388511565	483	A>D	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q80ZU5

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton Cell projection, cilium, flagellum	Localizes to the microtubular manchette of elongating spermatids (PubMed:28283191) Localizes to the sperm flagella and to the basal half of motile cilia (PubMed:28283191)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
manchette	A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
sperm flagellum	A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.

Name	Definition
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.

Name	Definition
No GO annotations for biological process

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6AYN9	Ccdc181	Coiled-coil domain-containing protein 181	Rattus norvegicus (Rat)	PR