Q80YS9

PR
Gene name
Stkld1 (Gm711, Sgk071)
Protein name
Serine/threonine kinase-like domain-containing protein STKLD1
Names
Serine/threonine kinase-like domain-containing protein 1, Sugen kinase 071
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:279029
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

127-199 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

143-149 (Activation loop from InterPro)

Target domain

1-266 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q80YS9

Entry ID Method Resolution Chain Position Source
AF-Q80YS9-F1 Predicted AlphaFoldDB

36 variants for Q80YS9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388539891 14 E>D No EVA
rs3388536920 83 T>R No EVA
rs3388539875 100 T>S No EVA
rs234561537 119 K>T No EVA
rs3388533191 121 N>S No EVA
rs3388533874 169 S>F No EVA
rs3388535098 175 A>S No EVA
rs3412795719 214 I>T No EVA
rs3391245342 240 Y>D No EVA
rs3391405458 245 F>S No EVA
rs3388535557 325 P>S No EVA
rs3388539862 329 L>P No EVA
rs214993610 338 L>V No EVA
rs27185352 350 R>Q No EVA
rs3388536078 367 G>D No EVA
rs3388533217 370 L>P No EVA
rs260390178 380 R>K No EVA
rs3388537872 426 G>R No EVA
rs3388535564 440 E>K No EVA
rs3388535589 447 S>F No EVA
rs255780603 462 V>L No EVA
rs27185346 477 V>A No EVA
rs3388540507 498 L>M No EVA
rs3388540489 508 Q>* No EVA
rs3388540524 508 Q>R No EVA
rs3388533164 521 Q>K No EVA
rs3388532183 576 E>G No EVA
rs3388536067 585 L>M No EVA
rs3388533854 613 R>H No EVA
rs3388538578 627 I>V No EVA
rs213873702 636 Q>H No EVA
rs3391245335 638 G>A No EVA
rs3391400123 642 D>A No EVA
rs3391400081 645 E>D No EVA
rs3391363998 648 A>G No EVA
rs3391393961 651 E>D No EVA

No associated diseases with Q80YS9

1 regional properties for Q80YS9

Type Name Position InterPro Accession
domain Protein kinase domain 1 - 266 IPR000719

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P18431 sgg Protein kinase shaggy Drosophila melanogaster (Fruit fly) SS
P49840 GSK3A Glycogen synthase kinase-3 alpha Homo sapiens (Human) PR
P49841 GSK3B Glycogen synthase kinase-3 beta Homo sapiens (Human) EV
Q8NE28 STKLD1 Serine/threonine kinase-like domain-containing protein STKLD1 Homo sapiens (Human) PR
Q9WV60 Gsk3b Glycogen synthase kinase-3 beta Mus musculus (Mouse) EV
Q2NL51 Gsk3a Glycogen synthase kinase-3 alpha Mus musculus (Mouse) SS
P18266 Gsk3b Glycogen synthase kinase-3 beta Rattus norvegicus (Rat) PR
P18265 Gsk3a Glycogen synthase kinase-3 alpha Rattus norvegicus (Rat) PR
Q09595 R03D7.5 Putative serine/threonine-protein kinase R03D7.5 Caenorhabditis elegans PR
Q9U2Q9 gsk-3 Glycogen synthase kinase-3 Caenorhabditis elegans PR
Q39019 ASK10 Shaggy-related protein kinase kappa Arabidopsis thaliana (Mouse-ear cress) PR
Q9FVS6 ASK4 Shaggy-related protein kinase delta Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MLNPGALGVN LVVEELETET KFLIKQVECI DEHHANKALE ELMPLLKLQH PNLSLYHEMF
70 80 90 100 110 120
IMWNNEISSL FLCLVMDYYS QGTFQNIMEN KRKLKAVVDT EWMHTMLSQV LDAIEYLHKL
130 140 150 160 170 180
NIVHRNLKPS NIVLVNSGYC KLQDMSSQAL MTHEAKWNVR AEEDPCQKSW MAPEALKFSF
190 200 210 220 230 240
STKSDIWSLG CIILDMATCS FLNDTEAMQL RKAIRHHPGS LKPILKTMEE KQIPGTDVYY
250 260 270 280 290 300
LLLPFMLHIN PSDRLAIKDV MQVTFMSNSF KSSSVALNMQ RQKVPIFITD VLLEGNMANI
310 320 330 340 350 360
LDVMQNFSSR PEVQLRAINK LLTMPEDQLG LPWPTELLEE VISIIKQHGR ILDILLSTCS
370 380 390 400 410 420
LLLRVLGQAL AKDPEAEIPR SSLIISFLMD TLRSHPNSER LVNVVYNVLA IISSQGQISE
430 440 450 460 470 480
ELEEEGLFQL AQENLEHFQE DRDICLSILS LLWSLLVDVV TVDKEPLEQL SGMVTWVLAT
490 500 510 520 530 540
HPEDVEIAEA GCAVLWLLSL LGCIKESQFE QVVVLLLRSI QLCPGRVLLV NNAFRGLASL
550 560 570 580 590 600
AKVSELVAFR IVVLEEGSSG LHLIQDIYKL YKDDPEVVEN LCMLLAHLTS YKEILPEMES
610 620 630 640 650 660
GGIKDLVQVI RGRFTSSLEL ISYADEILQV LEANAQPGLQ EDQLEPPAGQ EAPLQGEPLF
RP