Q39019
Gene name |
ASK10 (HIR1, SK41) |
Protein name |
Shaggy-related protein kinase kappa |
Names |
AtHIR1, ASK-kappa, AtK-1, Shaggy-related protein kinase 41, AtSK41 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G09840 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
226-248 (Activation loop from InterPro)
Target domain |
83-367 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q39019
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q39019-F1 | Predicted | AlphaFoldDB |
17 variants for Q39019
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_3199521_C_T | 2 | A>T | No | 1000Genomes | |
| ENSVATH04546639 | 5 | G>E | No | 1000Genomes | |
| tmp_1_3199505_C_A | 7 | G>V | No | 1000Genomes | |
| ENSVATH00014325 | 10 | V>I | No | 1000Genomes | |
| ENSVATH04546638 | 24 | S>N | No | 1000Genomes | |
| ENSVATH01029031 | 35 | E>V | No | 1000Genomes | |
| ENSVATH10862828 | 68 | T>A | No | 1000Genomes | |
| ENSVATH10862827 | 88 | V>I | No | 1000Genomes | |
| tmp_1_3198836_C_G | 130 | M>I | No | 1000Genomes | |
| ENSVATH10862563 | 152 | V>A | No | 1000Genomes | |
| ENSVATH04546624 | 192 | C>F | No | 1000Genomes | |
| tmp_1_3197622_C_T | 290 | V>I | No | 1000Genomes | |
| tmp_1_3196605_T_C | 363 | I>V | No | 1000Genomes | |
| tmp_1_3196536_G_A | 386 | L>F | No | 1000Genomes | |
| tmp_1_3196194_C_A | 396 | G>C | No | 1000Genomes | |
| ENSVATH10862041 | 398 | P>L | No | 1000Genomes | |
| ENSVATH04546604 | 419 | L>F | No | 1000Genomes |
No associated diseases with Q39019
3 regional properties for Q39019
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Heat shock protein 70, conserved site | 9 - 16 | IPR018181-1 |
| conserved_site | Heat shock protein 70, conserved site | 197 - 210 | IPR018181-2 |
| conserved_site | Heat shock protein 70, conserved site | 334 - 348 | IPR018181-3 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P18431 | sgg | Protein kinase shaggy | Drosophila melanogaster (Fruit fly) | SS |
| P49840 | GSK3A | Glycogen synthase kinase-3 alpha | Homo sapiens (Human) | PR |
| P49841 | GSK3B | Glycogen synthase kinase-3 beta | Homo sapiens (Human) | EV |
| Q80YS9 | Stkld1 | Serine/threonine kinase-like domain-containing protein STKLD1 | Mus musculus (Mouse) | PR |
| Q2NL51 | Gsk3a | Glycogen synthase kinase-3 alpha | Mus musculus (Mouse) | SS |
| Q9WV60 | Gsk3b | Glycogen synthase kinase-3 beta | Mus musculus (Mouse) | EV |
| P18265 | Gsk3a | Glycogen synthase kinase-3 alpha | Rattus norvegicus (Rat) | PR |
| P18266 | Gsk3b | Glycogen synthase kinase-3 beta | Rattus norvegicus (Rat) | PR |
| Q09595 | R03D7.5 | Putative serine/threonine-protein kinase R03D7.5 | Caenorhabditis elegans | PR |
| Q9U2Q9 | gsk-3 | Glycogen synthase kinase-3 | Caenorhabditis elegans | PR |
| Q9FVS6 | ASK4 | Shaggy-related protein kinase delta | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASSGLGNGV | GTSRSAKGLK | SSSSSVDWLT | RDLAETRIRD | KVETDDERDS | EPDIIDGAGA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EPGHVIRTTL | RGRNGQSRQT | VSYISEHVVG | TGSFGMVFQA | KCRETGEVVA | IKKVLQDKRY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KNRELQIMQM | LDHPNAVALK | HSFFSRTDNE | EVYLNLVLEF | VPETVNRVAR | SYSRTNQLMP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LIYVKLYTYQ | ICRALAYIHN | SFGLCHRDIK | PQNLLVNPHT | HQLKICDFGS | AKVLVKGEPN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VSYICSRYYR | APELIFGASE | YTTAIDIWST | GCVMAELLLG | QPLFPGESGV | DQLVEIIKVL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GTPTREEIKC | MNPNYTEFKF | PQIKPHPWHK | VFQKRLPPEA | VDLLCRFFQY | SPNLRCTALE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ACIHPLFDEL | RDPNTRLPNG | RPLPPLFNFK | PQELSGIPPE | IVNRLVPEHA | RKQNLFMALH |
| S |