Q80XC6
PR
Gene name |
Nrde2 |
Protein name |
Nuclear exosome regulator NRDE2 |
Names |
Protein NRDE2 homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:217827 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80XC6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80XC6-F1 | Predicted | AlphaFoldDB |
79 variants for Q80XC6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs251072869 | 19 | F>S | No | EVA | |
| rs49177424 | 29 | P>S | No | EVA | |
| rs218712451 | 46 | V>A | No | EVA | |
| rs253996368 | 55 | P>L | No | EVA | |
| rs226355115 | 63 | R>W | No | EVA | |
| rs3403644430 | 72 | G>A | No | EVA | |
| rs3403614619 | 72 | G>R | No | EVA | |
| rs216350176 | 75 | N>D | No | EVA | |
| rs256946735 | 82 | Q>H | No | EVA | |
| rs231964824 | 83 | T>I | No | EVA | |
| rs3389269413 | 105 | R>K | No | EVA | |
| rs45859201 | 110 | L>S | No | EVA | |
| rs242933879 | 113 | S>N | No | EVA | |
| rs3389258542 | 115 | S>Y | No | EVA | |
| rs223389279 | 121 | A>P | No | EVA | |
| rs3389228477 | 176 | K>M | No | EVA | |
| rs3389251634 | 194 | R>S | No | EVA | |
| rs3389250520 | 196 | K>N | No | EVA | |
| rs3389228557 | 236 | N>* | No | EVA | |
| rs3389264651 | 236 | N>S | No | EVA | |
| rs3389264652 | 238 | G>E | No | EVA | |
| rs3389248093 | 241 | R>G | No | EVA | |
| rs3389187219 | 245 | I>T | No | EVA | |
| rs3389255429 | 249 | S>C | No | EVA | |
| rs249452124 | 249 | S>T | No | EVA | |
| rs3389264706 | 260 | T>I | No | EVA | |
| rs3389269370 | 261 | F>I | No | EVA | |
| rs3389255465 | 277 | W>R | No | EVA | |
| rs6341175 | 332 | W>R | No | EVA | |
| rs3403753082 | 369 | K>* | No | EVA | |
| rs3389263449 | 393 | K>R | No | EVA | |
| rs3389256671 | 444 | S>P | No | EVA | |
| rs3389255415 | 445 | K>I | No | EVA | |
| rs220807878 | 447 | H>L | No | EVA | |
| rs3389251643 | 448 | S>R | No | EVA | |
| rs3389187220 | 480 | G>R | No | EVA | |
| rs3389255403 | 496 | E>K | No | EVA | |
| rs3389263414 | 516 | V>M | No | EVA | |
| rs234542343 | 535 | G>R | No | EVA | |
| rs234787660 | 562 | I>V | No | EVA | |
| rs3389213899 | 569 | E>K | No | EVA | |
| rs245090336 | 594 | R>H | No | EVA | |
| rs3389248160 | 600 | H>N | No | EVA | |
| rs3389222862 | 606 | P>L | No | EVA | |
| rs3389256728 | 624 | V>M | No | EVA | |
| rs3389251694 | 635 | R>K | No | EVA | |
| rs3389240378 | 638 | S>I | No | EVA | |
| rs3389263482 | 684 | K>R | No | EVA | |
| rs3389248166 | 687 | T>I | No | EVA | |
| rs3389252818 | 693 | F>L | No | EVA | |
| rs6238974 | 707 | R>C | No | EVA | |
| rs387905415 | 707 | R>H | No | EVA | |
| rs3403807523 | 709 | R>L | No | EVA | |
| rs3402918205 | 712 | K>* | No | EVA | |
| rs3403807563 | 712 | K>I | No | EVA | |
| rs3403637690 | 715 | N>S | No | EVA | |
| rs3389264673 | 716 | R>* | No | EVA | |
| rs6238859 | 733 | L>F | No | EVA | |
| rs387370555 | 741 | L>V | No | EVA | |
| rs260101861 | 742 | S>C | No | EVA | |
| rs3389256698 | 754 | I>F | No | EVA | |
| rs3389256702 | 760 | K>* | No | EVA | |
| rs3389222828 | 764 | L>S | No | EVA | |
| rs246644070 | 770 | S>N | No | EVA | |
| rs3389228545 | 790 | L>I | No | EVA | |
| rs3403947415 | 866 | P>V* | No | EVA | |
| rs237074706 | 868 | G>R | No | EVA | |
| rs3389264729 | 898 | C>R | No | EVA | |
| rs3389248091 | 899 | A>G | No | EVA | |
| rs254426146 | 903 | A>V | No | EVA | |
| rs3389264670 | 910 | C>S | No | EVA | |
| rs3389187250 | 966 | L>F | No | EVA | |
| rs3389228538 | 1016 | Q>H | No | EVA | |
| rs3389187213 | 1023 | N>K | No | EVA | |
| rs3389213930 | 1037 | K>I | No | EVA | |
| rs3389269446 | 1095 | Q>L | No | EVA | |
| rs3389240385 | 1097 | P>L | No | EVA | |
| rs3402268513 | 1110 | L>* | No | EVA | |
| rs247445707 | 1172 | D>G | No | EVA |
No associated diseases with Q80XC6
5 regional properties for Q80XC6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | HAT (Half-A-TPR) repeat | 404 - 436 | IPR003107-1 |
| repeat | HAT (Half-A-TPR) repeat | 765 - 800 | IPR003107-2 |
| repeat | HAT (Half-A-TPR) repeat | 802 - 841 | IPR003107-3 |
| repeat | HAT (Half-A-TPR) repeat | 1075 - 1109 | IPR003107-4 |
| repeat | HAT (Half-A-TPR) repeat | 1111 - 1143 | IPR003107-5 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| negative regulation of RNA catabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process. |
| positive regulation of RNA export from nucleus | Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm. |
| post-transcriptional gene silencing by RNA | A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALFPAFADV | SEASGDGAFR | KELDWLSNPS | FRVGNLTSLS | RQTEEVTALA | SEGSPPPRYS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FIRSPLKSEL | SGESNTSEKL | AQTSRKKKKE | KKKRRKHQHH | RKTKRRHEQL | SSSGSESDTE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AGKDRASRSI | RDDQKEAEKP | CQGSNAAAAV | AAAAGHRSIW | LEDIHDLTDV | FRTDKKPDPA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NWEYKSLYRG | DIARYKRKGD | SCLGINPKKQ | CISWEGASAA | KKHSHRHLER | YFTKKNVGLM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RTEGIAVCSN | PEPASSEPVT | FIPVKDSAEA | ATPVTSWLNP | LGIYDQSTTQ | WLQGQGPAEQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ESKQPDSQQD | RENAALKARV | EEFNRRVREN | PWDTQLWMAF | VAFQDEVMRS | PGIYALGEGE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QEKHRKSLKL | LLEKKLAVLE | RAIESNPGSV | ELKLAKLQLC | SEFWEPSALA | KEWQKLLFLH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PNNTSLWQRY | LSFCQSQFGT | FSVSKLHSLY | GKCLSTLSAV | KDGSMLSHPV | LPGTEEAMFG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LFLQQCHFLR | QAGHSEKVIS | LFQAMVDFTF | FKPDSVKELP | TKVQVEFFEP | FWDSGEPRVG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EKGARGWRAW | MHQQERGGWV | LITPDEDDEE | PEEEDQEIKD | KTLPRWQIWL | AVERSRDQRH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| WRPWRPDKTK | KQTEEDCEDP | ERQVLFDDIG | QSLIRLSSPD | LQFQLIQAFL | QFLGVPSGFL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PPASCLYLAM | DESSIFESEL | YDEKPLTYFN | PSFSGISCVG | SMEQLGRPRW | TKGHNREGEE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| FVRNVFHLVL | PLLAGKQKSQ | LSLSWLRYEI | AKVIWCLHTK | KKRLKSQGKS | CKKLAKNLLK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EPENRNNFCL | WKQYAHLEWL | LGNTEDARKV | FDTALSMAGS | SELKDRELCE | LSLLYAELEM |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ELSPDSRGAT | TGRAVHILTR | LTESSPYGPY | TGQVSSTQVL | KARKAYELAL | QDCLGQSCAS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SPAPAEALDC | LGSLVRCFML | FQYLTVGIDA | AVQIYGRVFA | KLKGSARLED | PGPEDSTSSQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SLTNVLEAVS | MMHTSLLRFH | MNVCVYPLAP | LRETLSDALK | LYPGNQVLWR | AYVQIQNKSH |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SANKTRRFFD | TVTRSAKHLE | PWLFAIEAEK | LRKKLVESVQ | RVGGREVHAT | IPETGLTHRI |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| RALFENAIRS | DKGNQCPLLW | RMYLNFLVSL | GNKERSKGVF | YKALQSCPWA | KVLYMDAMEY |
| 1150 | 1160 | 1170 | |||
| FPDELQEILD | VMTEKELRVR | LPLEELELLL | ED |