G5EG51
Gene name |
nrde-2 (T01E8.5) |
Protein name |
Nuclear exosome regulator NRDE2 |
Names |
Nuclear RNAi defective-2 protein |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_T01E8.5 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for G5EG51
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-G5EG51-F1 | Predicted | AlphaFoldDB |
No variants for G5EG51
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for G5EG51 | |||||
No associated diseases with G5EG51
No regional properties for G5EG51
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for G5EG51 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| gene silencing by RNA | A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. |
| heterochromatin assembly by small RNA | A heterochromatin formation-based gene silencing process mediated by a small RNA molecule that occur before the beginnning of trancription. |
| negative regulation of RNA catabolic process | Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process. |
| post-transcriptional gene silencing by RNA | A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFRAYGNNGL | KNPERISGEN | PDLYTQTRAA | VQQRATTTLK | RNEKQKLAVQ | NDSVFQQVGI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GESDSDDDNG | GVRIRMSPHR | YIDPDDVFTL | PEVKKQNALR | DAKIAARAAQ | ATAYNTFPSV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KSLNGCQDPP | ETSQQSTSRK | RSASNSRSPS | RSHSRRYDRD | NGRQRSRSRE | KKRRKKERRR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KRSSSRSSSS | SRSRDRSSRA | RDTSSHTLMK | MNKPAKYAFL | TDEEYRTCDA | YISSAFITQT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KSDCENYTQG | VPKKEIAKCR | LSVKFIVGLE | HNNILFNNIY | GAEYARDKEN | RPFWEQLDRY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LKDVPKETFF | RYVPPVGGYW | KIRDRVDLLN | LDHIDDDVLA | NDSDNRKDAF | TFELEQAKKT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FSENVHNIDA | LIKVISMEEE | MCRRNVGSFS | SSNPAALAER | HQEMVKKAIK | ADGRNAKLRL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MKIELLIKMD | PNSPTIIDDF | KNLTITFPHE | PMVWIKYLDY | IQYDSNVYNY | KKLKNAFEDC |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IRQVTGLTNG | TLLSHLNAVN | DRPLLRMFHL | WIYIRYLKWM | ISCAHTPVVL | ANIQATFEYN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FGLADVEKRT | STNSKEREVR | LEEFWESGLP | RIGDEGAVGA | EKMLKQSEEL | SDEDIQKLEN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DDFDILISRT | EETIATCLQA | QRDVQISWIE | VEREMMNIDA | RVKRTKLKDC | ELYEDHVDDL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ETCELWDIIP | FDRIRYYEAP | GDCANFDFVQ | PFLELLGVKF | LNSTNCFTTT | EQIISDWISN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DSTVNFYKTP | TYTEKKCFEV | GNNILKFMLY | NRLKLTENNP | EYLDKTMVKY | LLAMLVTEAS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EQEKKLNFHS | FKLNLKNLVG | TFITKHPDIF | KRAMLSKITG | IVYMEKFVSW | WERALKEQEK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VVEADERRKN | YKEIKMEEGV | VDDVKFDVIL | LKKDKERVQT | IRDKIRDMID | IAIPKSTEKL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| IQSADSSLPT | LQLHLYANVL | RGRLSILNQN | ALEETRDVFC | KEILGIHTSE | FESDEALLLA |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LDQGLNELLE | HCKEKDNLES | VDSIPELPRA | EALCEALKVV | AVFVFLDKMA | FSRRAVDCLI |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ANAITKFEQF | EAKKNDFNRG | TYEKYCDQID | LKFITDTLIT | FFSHKKHRFI | YNENFKKLIF |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| QASQAFPCDS | KYAKMLGELH | SSGRLQVMKL | QGFTDSRNSI | LNAKRDQQFD | PELETRLLMN |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| SLTIMFSWMN | AANRIGDAGN | QILYKNWKRE | AANTRDPAIW | RQVIRVASKL | SQKILKDDAY |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| TRARGQCTWA | LNLHFDYIEA | KTVRKNGDLM | EMIYLILEQS | MGQEHSLFVT | DEEYMKTQQE |
| IGLQYSESGR |